Inhibitor of cytokine activity and applications thereof

• US 5,942,220 A
• Filed: 03/16/1990
• Issued: 08/24/1999
• Est. Priority Date: 03/16/1990
• Status: Expired due to Fees

• Current Assignee: Chiron Corporation (Bayer AG)
• Original Assignee: Chiron Corporation (Bayer AG)
• Inventors: Conroy, Leah B., Warren, Mary Kim, Drummund, Robert
• Primary Examiner(s): Smith, Lynette F.
• Application Number:
  US07/494,624
• Time in Patent Office: 3,448 Days
• Field of Search: 530/351, 514/12, 424/85.1
• US Class Current: 424/85.1
• CPC Class Codes: A61K 38/00 Medicinal preparations containing peptides peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00
• CPC Class Codes: C07K 14/575 Hormones derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin C07K14/665, e.g. corticotropin C07K14/695
• CPC Class Codes: G01N 33/6869 Interleukin
• CPC Class Codes: Y02A 50/30 Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

Described herein are compositions that have prophylactic or therapeutic applications for disease resulting from the production of cytokines, and preferably the cytokine IL-6, wherein the compositions consist of activin like molecules.

Claims

1. A method of treating an animal suffering from a disease resulting from IL-6 cytokine expression, comprising administering to said animal a therapeutically effective amount of activin.

2. A method as described in claim 1 wherein said disease is cancer.

3. A method in accordance with claim 1, wherein the disease is sepsis.