Mucoadhesive compositions for administration of biologically active agents to animal tissue
First Claim
Patent Images
1. A mucoadhesive hydrophilic drug delivery system comprising:
- (A) a drug or a plurality of drugs to be delivered, and(B) a drug delivery vehicle consisting essentially of a thermoplastic graft copolymer, said graft copolymer being a reaction product of;
(1) a polystyrene macromonomer having an ethylenically unsaturated functional group, and(2) at least one hydrophilic acidic monomer having an ethylenically unsaturated functional group,wherein the weight percent of the polystyrene macromonomer in the graft copolymer is between about 1 and about 20%, and the weight percent of the total hydrophilic monomer in the graft copolymer is between 80 and 99%, wherein at least about 10% of said total hydrophilic monomer is acidic, said graft copolymer when fully hydrated having an equilibrium water content of at least 90%,said graft copolymer being present in said drug delivery system in an amount sufficient to cause said drug delivery system to form a water swollen but insoluble jelly like mass upon contact with the biological environment.
2 Assignments
0 Petitions
Accused Products
Abstract
This invention pertains to mucoadhesive compositions for the delivery of pharmacologically active agents, and to polymeric formulations that allow for a prolonged, sustained release of the active agents. More specically the invention pertains to compositions for the delivery of drugs to mucosal tissue, said composition comprising a drug or a plurality of drugs to be delivered and a thermoplastic graft copolymer, said graft copolymer being the reaction product of a polystyrene macromonomer having an ethylenically unsaturated functional group, and at least one acidic hydrophilic monomer having an ethylenically unsaturated functional group.
-
Citations
21 Claims
-
1. A mucoadhesive hydrophilic drug delivery system comprising:
-
(A) a drug or a plurality of drugs to be delivered, and (B) a drug delivery vehicle consisting essentially of a thermoplastic graft copolymer, said graft copolymer being a reaction product of; (1) a polystyrene macromonomer having an ethylenically unsaturated functional group, and (2) at least one hydrophilic acidic monomer having an ethylenically unsaturated functional group, wherein the weight percent of the polystyrene macromonomer in the graft copolymer is between about 1 and about 20%, and the weight percent of the total hydrophilic monomer in the graft copolymer is between 80 and 99%, wherein at least about 10% of said total hydrophilic monomer is acidic, said graft copolymer when fully hydrated having an equilibrium water content of at least 90%, said graft copolymer being present in said drug delivery system in an amount sufficient to cause said drug delivery system to form a water swollen but insoluble jelly like mass upon contact with the biological environment. - View Dependent Claims (3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 21)
-
-
2. A sustained release mucoadhesive hydrophilic drug delivery system comprising:
-
(A) a drug or a plurality of drugs to be delivered, and (B) a drug delivery vehicle consisting essentially of a thermoplastic graft copolymer, said graft copolymer being a reaction product of; (1) a polystyrene macromonomer having an ethylenically unsaturated functional group, and (2) at least one hydrophilic acidic monomer having an ethylenically unsaturated functional group, wherein the weight percent of the polystyrene macromonomer in the graft copolymer is between about 1 and about 20%, and the weight percent of the total hydrophilic monomer in the graft copolymer is between 80 and 99%, wherein at least about 10% of said total hydrophilic monomer is acidic, said graft copolymer when fully hydrated having an equilibrium water content of at least 90%, said graft copolymer being present in said drug delivery system in an amount sufficient to cause said drug delivery system to form a water swollen but insoluble jelly like mass upon contact with the biological environment.
-
-
18. A sustained release mucoadhesive hydrophilic drug delivery system comprising:
-
(A) a drug or a plurality of drugs to be delivered, and (B) a drug delivery vehicle consisting essentially of a thermoplastic graft copolymer, said graft copolymer being a reaction product of; (1) a polystyrene macromonomer having an ethylenically unsaturated functional group, and (2) at least one hydrophilic acidic monomer having an ethylenically unsaturated functional group, (3) and a hydrophilic neutral monomer having an ethylenically unsaturated functional group, wherein the weight percent of the polystyrene macromonomer in the graft copolymer is between about 1 and about 20%, and the weight percent of the total hydrophilic monomer in the graft copolymer is between 80 and 99%, wherein at least about 10% of said total hydrophilic monomer is acidic, said graft copolymer when fully hydrated having an equilibrium water content of at least 90%, (C) a plasticizer said graft copolymer being present in said drug delivery system in an amount sufficient to cause said drug delivery system to form a water swollen but insoluble jelly like mass upon contact with the biological environment. - View Dependent Claims (19, 20)
-
Specification