Microbicidal and sanitizing soap compositions

• US 5,942,478 A
• Filed: 09/04/1997
• Issued: 08/24/1999
• Est. Priority Date: 09/19/1995
• Status: Expired due to Term

• Current Assignee: John A. Lopes
• Original Assignee: John A. Lopes
• Inventors: Lopes, John A.
• Primary Examiner(s): OGDEN JR, NECHOLUS
• Application Number:
  US08/923,616
• Time in Patent Office: 719 Days
• Field of Search: 510/130, 510/13.1, 510/137, 510/119, 510/124, 510/127, 510/129, 424/70.1, 424/70.5, 424/70.11, 424/70.12, 424/70.13, 424/70.22, 424/70.24, 424/78.02, 424/55, 424/49, 424/56, 424/44
• US Class Current: 510/130
• CPC Class Codes: A61K 8/466 containing sulfonic acid derivatives; Salts
• CPC Class Codes: A61K 8/73 Polysaccharides
• CPC Class Codes: A61Q 17/005 Antimicrobial preparations
• CPC Class Codes: A61Q 19/10 Washing or bathing preparations

Abstract

This invention relates to microbicidal and sanitizing soap compositions. More particularly, the invention relates to microbicidal and sanitizing soap compositions that incorporate agents with tuberculocidal properties in ready-to-use form that has gel properties or thixotropic-properties and to soap concentrate compositions suitable for dilution in or with water or non-aqueous diluent to produce gel-like or thixotropic solutions or dispersions ranging from free flowing to solidified forms. The ready-to-use compositions and the concentrate compositions are applied for purposes of personal or animal hygiene or sanitizing on hair, hands and skin or other body parts, or are applied on inanimate surfaces and objects that need to be sanitized.

Claims

1. A soap concentrate composition, capable for use in dilution with pH-adjustable topical diluent to form a microbicidal lubricating solution or dispersion for use in protecting skin and non-skin surfaces against infection, the soap composition consisting essentially of:

a) an anionic surfactant present in said solution and/or dispersion form the range from about 0.1 weight percent to about 95 weight percent based on the total weight of the concentrate composition,

b) a skin-lubricating and skin-protecting agent selected from natural gum polymers and synthetic gum polymers of the group consisting essentially of polysaccharide based xanthan, arabic, ghatti, carrageenin, karaya, tragacanth, agar-agar, Irish moss, Iceland moss, algin, guar, locust kernel, locust bean, quince seed, pectins, dextrins, cellulose ethers, starch and cellulose polymers, acrylate polymers, carboxylate polymers, sulfated polymers, polyvinyl pyrrolidones, poloxamers, and silicone based polymers, and mixtures of two or more said polymers, the skin-lubricating agent and skin-protecting agent in said use form being present in an amount ranging from 0.1 weight percent to about 25 weight percent based on the total weight of the concentrate composition, and

c) an acidifying agent selected from acids of the group consisting essentially of acetic acid, adipic acid, ascorbic acid, citric acid, dehydroacetic acid, erythorbic acid, fumaric acid, glutaric acid, gluconic acid, hyaluronic acid, glycolic acid, lactic acid, malic acid, sorbic acid, succinic acid, tannic acid, tartaric acid, sulfuric acid, phosphoric acid, nitric acid, hydrochloric acid, sulfamic acid, carboxylic acid polymers, homo- or hetero- polymerized α

-hydroxy carboxylic acids including poly lactic acid and poly lactic-glycolic acid and mixtures of two or more said acids, said acidifying agent being present in the concentrate composition in an amount adjusting the solution and/or dispersion form pH thereof below pH 5, said microbicidal protection resulting in reduction of the microbial population by a magnitude of five logarithmic units within 30 to 60 seconds.

2. A soap composition as in claim 1 comprising a skin conditioner component selected from the group of conditioners and moisturing agents consisting of aloe vera, vitamins A, C, D, and E, menthol, thymol, tea tree oil, plant extract, sea weed extract, protein hydrolysates, fatty alcohols, fatty alcohol esters, sphingolipids, and mixtures of 2 or more said conditioners, in an amount ranging from 0.01 weight percent to about 20 weight percent based on the total weight percent of the concentrate composition.

3. A microbicidal soap composition as in claim 1 comprising a generally regarded as safe GRAS compound selected from the group of components consisting of benzoic acid, benzoic acid salts, benzoic acid esters, sorbic acid, sorbic acid salts, sorbic acid esters, parabens, alkyl lactylate esters, citrate esters, alkyl malate esters, alkyl glycolate esters, fatty acids, fatty acid salts and fatty acid esters, and mixtures of two or more said components.

4. A soap concentrate composition as in claim 1 diluted in solution and/or dispersion form with diluent selected from the group of diluents consisting essentially of water, ethanol, propanols, glycols, and mixtures of two or more said diluents.

5. A soap concentrate composition as in claim 3 comprising a component of the group consisting of a free acid, salt or ester form of benzoic acid, dehydroacetic acid, mono- n-alkyl and mono- n-alkenyl acyl esters of C2-C4 hydroxylated monocarboxylic acids in which the alkyl or alkenyl group contains from six to eighteen carbon atoms, and mixtures of two or more said components, said component being present in an amount between 0.005% weight percent to about 20% weight percent based on the total weight of the concentrate composition.

6. A soap concentrate composition as in claim 5 wherein said components are sodium decyl lactylate, benzoic acid and dehydroacetic acid, and mixtures of two or more said components.

7. An acidifying agent as in claim 1 comprising a hydroxy acid selected from the group consisting of citric, glycolic, lactic, malic and tartaric acids, and mixtures of two or more said acids.

8. A soap composition as in claim 1 wherein the surfactant is selected from the group of surfactants consisting of the free acid or salt forms of:

C6-C18 alkyl- and alkenyl- sulfates;

C6-C18 alkyl- and alkenyl- ether sulfates;

C8-C16 alkyl diphenyl ether disulfonates;

C4-C18 fatty acid isethionates;

C6-C18 alkyl- and alkenyl sulfonates;

dialkyl- and dialkenyl sulfosuccinates in which the alkyl or alkenyl groups independently contain from six to eighteen carbon atoms;

C6-C18 alkylbenzene sulfonates;

naphthalene sulfonates;

alkyl naphthalene sulfonates in which alkyl group contains from one to six carbon atoms;

the mono- n-alkyl and mono- n-alkenyl acyl esters of C2-C4 hydroxylated monocarboxylic acids in which the Alkyl or alkenyl group contains from six to eighteen carbon atoms;

the mono- n-alkyl and mono- n-alkenyl acyl esters of C2-C4 hydroxylated dicarboxylic acids in which the alkyl or alkenyl group contains six to eighteen carbon atoms;

the mono- n-alkyl and mono- n-alkenyl alkyl esters of C2-C4 Dicarboxylic acids, in which the alkyl or alkenyl group contains from six to eighteen carbon atoms; and

C4-C18 fatty alcohol sulfoacetates, and mixtures of two or more said surfactants.

9. A soap composition as in claim 8 comprising a surfactant of the group consisting of sodium alpha olefin C₁₄ -C₁₆ sulfonate, sodium C₄ -C₁₈ fatty acid esters of isethionate, sodium C₄ -C₁₈ fatty alcohol esters of sulfoacetate, and mixtures of two or more said surfactants.

10. A soap concentrate composition as in claim 1 comprising a nonionic foaming agent selected from the group consisting of polyols, poloxamers, acyl derivatives of sugars, acyl derivatives of carbohydrates, and mixtures of two or more said nonionic foaming agents.

11. A microbicidal soap composition as in claim 1 wherein the skin-lubricating and skin-protecting agent serves as a thixotropic and/or solidifying agent.

12. A soap composition as in claim 1 in the form of a solid bar, dry powder, gel, liquid or a foaming product.

13. A microbicidal composition having tuberculocidal activity as in claim 8.

14. An antitubercular composition having antitubercular activity as in claim 8.

15. A composition as in claim 1 in solution and/or dispersion form comprising an anhydrous diluent for the composition selected from propanol, isopropanol, propylene glycol, acetic acid, hydroxyacetic acid, propionic acid, ethyl lactate, and mixtures thereof.

16. A composition as in claim 1 comprising a sequestering agent selected from ethylene diamine tetraacetic acid, sodium acid pyrophosphate, sodium phosphate, chlorides, sulfates, citrates, nitrates, acetates, and lactates of potassium, sodium, ammonium, and zinc, and mixtures of two more said sequestering agents.

17. A composition as in claim 16 wherein the concentrate composition is diluted with water in ready-to-use form.

21. A soap composition as in claim 1 that at pH<

3 in diluted solution and/or dispersion form is cidal for Mycobacterium tuberculosis when applied to body surfaces or sanitizable surfaces within one-half to two minutes.

18. A non-aqueous bactericidal and antimicrobial soap concentrate composition, capable for use in diluting with pH-adjustable topical diluent to form a bactericidal and antimicrobial lubricating solution or dispersion for use in protecting skin and non-skin surfaces against infection said solution or dispersion being cidal for Mycobacterium tuberculosis when applied to body surfaces or sanitizable surfaces within one-half to two minutes, the soap composition consisting essentially of:

a) an anionic surfactant present in said use form in an amount in the range from about 0.1 weight percent to about 95 percent based on the total weight of the concentrate composition,

b) a skin-lubricating and skin-protecting agent selected from natural gum polymers and synthetic gum polymers of the group consisting essentially of polysaccharide based xanthan, arabic, ghatti, carrageenin, karays, tragacanth, agar-agar, Irish moss, Iceland moss, algin, guar, locust kernel, locust bean, quince seed, pectins, dextrins, cellulose ethers, modified starch and cellulose polymers, acrylate polymers, carboxylate polymers, sulfated polymers, polyvinyl pyrrolidones, poloxamers, and silicone based polymers, and mixtures of two or more said polymers, the skin-lubricating agent and skin-protecting agent in said use form being present in an amount ranging from 0.1 weight percent to about 25 weight percent based on the total weight of the concentrate composition, and

c) an acidifying agent selected from acids of the group consisting essentially of acetic acid, adipic acid, ascorbic acid, citric acid, dehydroacetic acid, erythorbic acid, fumaric acid, glutaric acid, gluconic acid, hyaluronic acid, glycolic acid, lactic acid, malic acid, sorbic acid, succinic acid, tannic acid, tartaric acid, sulfuric acid, phosphoric acid, nitric acid, hydrochloric acid, sulfamic acid, carboxylic acid polymers, homo- or hetero-polymerized α

hydroxy carboxylic acids including poly lactic acid and poly lactic-glycolic acid and mixtures of two or more said acids, said acidifying agent being present in the concentrate composition in an amount fixing the use from pH thereof below pH 5.

19. A soap concentrate composition as in claim 18 comprising a skin conditioner component selected from the group of conditioners and moisturing agents consisting of aloe vera, vitamins A, C, D, and E, menthol, thymol, tea tree oil, plant extract, sea weed extract, protein hydrolysates, fatty alcohols, fatty alcohol esters, sphingolipids, and mixtures of 2 or more said conditioners, in an amount ranging from 0.01 weight percent to about 20 weight percent based on the total weight percent of the concentrate composition.

20. A soap concentrate composition as in claim 18 comprising a generally regarded as safe GRAS compound component selected from the group of components consisting of benzoic acid, benzoic acid salts, benzoic acid esters, sorbic acid, sorbic acid salts, sorbic acid esters, parabens, alkyl lactylate esters, citrate esters, alkyl malate esters, alkyl glycolate esters, fatty acids, fatty acid salts and fatty acid esters, and mixtures of two or more said components.