Radiopharmaceutical capsule safe

• US 5,944,190 A
• Filed: 05/30/1997
• Issued: 08/31/1999
• Est. Priority Date: 05/30/1997
• Status: Expired due to Term

• Current Assignee: Mallinckrodt Nuclear Medicine LLC (Mallinckrodt plc)
• Original Assignee: Mallinckrodt Incorporated (Mallinckrodt plc)
• Inventors: Edelen, David A.
• Primary Examiner(s): FIDEI, DAVID
• Application Number:
  US08/865,995
• Time in Patent Office: 823 Days
• Field of Search: 206/528, 206/524.4, 250/506.1, 250/507.1
• US Class Current: 206/524.4
• CPC Class Codes: G21F 5/015 for storing radioactive sources, e.g. source carriers for irradiation units; Radioisotope containers

Abstract

A radiopharmaceutical capsule safe has a two-piece capsule vial that is sealed within a two-piece radiopaque safe which, in turn, is preferably contained within an outer jar. The cap of the two-piece vial is radiotransmissive such that the radiopharmaceutical capsule can be assayed simply by removing the lid portion of the safe from the bottom of the safe while leaving the radiopharmaceutical capsule environmentally sealed within the vial. After replacing the safe lid, the vial is opened by rotating the safe lid, which automatically turns the vial cap to disengage it from the vial bottom for dosing of the capsule to a patient.

Claims

1. A radiopharmaceutical capsule safe, comprising:

a safe comprising a safe bottom and a safe lid, said safe bottom and said safe lid each being formed from radiopaque material, said safe bottom having a vial bottom-receiving cavity formed therein and said safe lid having a vial cap-receiving cavity formed therein; and

a capsule vial comprising a vial bottom and a vial cap securable to said vial bottom, said vial cap being formed from radiotransmissive material and said vial bottom being configured to receive a radiopharmaceutical capsule therein;

wherein said vial bottom-receiving cavity and said vial bottom are cooperatively configured such that said vial bottom is receivable within said vial bottom-receiving cavity and wherein said vial cap-receiving cavity and said vial cap are cooperatively configured such that said vial cap is receivable within said vial cap-receiving cavity;

whereby said capsule vial can be encased completely within said safe to contain radiation emitted by said radiopharmaceutical capsule when said safe lid is engaged with said safe bottom, and whereby said radiopharmaceutical capsule can be assayed while environmentally sealed within said vial capsule by removing said safe lid from engagement with said safe bottom;

wherein both the vial cap and the vial bottom are releasably lock-engageable respectively with said safe bottom and said safe

wherein said vial bottom has two or more bottom tabs extending outwardly therefrom, said vial cap has two or more cap tabs extending outwardly therefrom, and said vial cap and said vial bottom are threadably engageable with each other; and

wherein said safe bottom has two or more lower slots extending along the vial bottom-receiving cavity to receive the bottom tabs and said safe lid has two or more upper slots extending along the vial cap-receiving cavity to receive the cap tabs;

whereby said vial cap can be disengaged from said vial bottom by rotating said safe lid relative to said safe bottom.

2. The radiopharmaceutical capsule safe of claim 1, wherein the upper slots have circumferentially oriented upper tab-engaging slot extensions which permit limited rotation of said safe lid relative to said vial cap.

3. The radiopharmaceutical capsule safe of claim 2, wherein said upper tab-engaging slot extensions are oriented such that the cap tabs are positioned within said upper tab-engaging slot extensions when said safe lid is rotated to disengage said vial cap from said vial bottom, whereby said vial cap is retained within said vial cap-receiving cavity when disengaged from said vial bottom.

4. The radiopharmaceutical capsule safe of claim 1, wherein the lower slots have circumferentially oriented lower tab-engaging slot extensions which permit limited rotation of said vial bottom relative to said safe bottom.

5. The radiopharmaceutical capsule safe of claim 4, wherein said lower tab-engaging slot extensions are oriented such that the bottom tabs are positioned within said lower tab-engaging slot extensions when said safe lid is rotated to disengage said vial cap from said vial bottom, whereby said vial bottom is retained within said vial bottom-receiving cavity when said safe bottom is inverted to dispense a radiopharmaceutical capsule contained within said vial bottom.

6. The radiopharmaceutical capsule safe of claim 1, further comprising an upper lock ring positioned in a lower portion of said vial cap-receiving cavity, and wherein said upper slots are formed in said upper lock ring.

7. The radiopharmaceutical capsule safe of claim 1, further comprising a lower lock ring positioned in an upper portion of said vial bottom-receiving cavity, and wherein said lower slots are formed in said lower lock ring.

8. The radiopharmaceutical capsule safe of claim 2, further comprising an upper lock ring positioned in a lower portion of said vial cap-receiving cavity, and wherein said upper slots and said upper tab-engaging slot extensions are formed in said upper lock ring.

9. The radiopharmaceutical capsule safe of claim 1, further comprising a lower lock ring positioned in an upper portion of said vial bottom-receiving cavity, and wherein said lower slots and said lower tab-engaging slot extensions are formed in said lower lock ring.

10. The radiopharmaceutical capsule safe of claim 1, further comprising an outer jar in which said safe is received, said outer jar comprising a jar bottom in which said safe bottom is received and a jar cap engageable with said jar bottom and configured to cover said safe lid.

11. The radiopharmaceutical capsule safe of claim 10, wherein said jar bottom has a retaining member which retains said safe bottom within said jar bottom.

12. The radiopharmaceutical capsule safe of claim 11, wherein said retaining member comprises an annular retaining ring disposed near an upper, open portion of said jar bottom.

16. The method of claim 12 wherein both the vial cap and the vial bottom are releasably lock-engageable respectively with said safe bottom and said safe lid.

13. A method of packaging a radiopharmaceutical capsule, said method comprising the steps:

providing a safe comprising a safe bottom and a safe lid, each being formed from radiopague material, said safe bottom and said safe lid being engageable with each other;

providing a capsule vial comprising a vial bottom and a vial cap, said vial cap being formed from radiotransmissive material and being engageable with said vial bottom wherein at least one of the vial cap and the vial bottom is releasably lock-engageable respectively with said safe bottom and said safe lid;

disposing said vial bottom in a vial bottom-receiving cavity formed in said safe bottom;

disposing said vial cap in a vial cap-receiving cavity formed in said safe lid;

disposing a radiopharmaceutical capsule in said vial bottom;

engaging said vial cap to said vial bottom; and

engaging said safe lid to said safe bottom; and

further comprising disposing activated charcoal in said vial bottom-receiving cavity before disposing said vial bottom in said vial bottom-receiving cavity.

14. The method of claim 13, wherein said vial cap is disposed in said vial cap-receiving cavity before said vial cap is engaged with said vial bottom, whereby said vial cap is engaged with said vial bottom generally simultaneously with said safe lid being engaged with said safe bottom.

15. The method of claim 13, further comprising providing a jar comprising a jar bottom and a jar cap, disposing said safe bottom in said jar bottom, and securing said jar cap to said jar bottom over said safe lid.