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Wearable peritoneum-based system for continuous renal function replacement and other biomedical applications

  • US 5,944,684 A
  • Filed: 06/02/1997
  • Issued: 08/31/1999
  • Est. Priority Date: 08/31/1995
  • Status: Expired due to Term
First Claim
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1. A method for the continuous removal of protein-bound uremic toxins from the blood which enters the peritoneal cavity of a patient, comprising the steps of:

  • a) introducing from about 250 to about 1000 ml of dialysate into the peritoneal cavity, wherein protein-bound uremic toxins from the blood translocate into said dialysate;

    b) removing the used dialysate from said peritoneal cavity;

    c) separating the used dialysate through a filter into a protein-containing fraction and an ultrafiltrate fraction;

    d) treating said ultrafiltrate fraction to remove waste products present in said ultrafiltrate fraction, thereby generating a purified ultrafiltrate fraction;

    e) treating said protein-containing fraction from said filter to remove undesirable proteins and noxious uremic substances bound to proteins, thereby generating detoxified proteins;

    f) combining said detoxified proteins and purified ultrafiltrate fraction to from regenerated dialysate;

    g) reintroducing said regenerated dialysate into the peritoneal cavity.

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