Opto-acoustic transducer for medical applications

• US 5,944,687 A
• Filed: 04/24/1996
• Issued: 08/31/1999
• Est. Priority Date: 04/24/1996
• Status: Expired due to Term

• Current Assignee: Lawrence Livermore National Security LLC (Government of the United States of America)
• Original Assignee: Regents of the University of California (University of California)
• Inventors: Da Silva, Luiz, Maitland, Duncan, Glinsky, Michael, Benett, William, Lee, Abraham, London, Richard, Matthews, Dennis, Celliers, Peter, Krulevich, Peter
• Primary Examiner(s): Buiz, Michael
• Assistant Examiner(s): PHAM, THUY D
• Application Number:
  US08/639,018
• Time in Patent Office: 1,224 Days
• Field of Search: 604/22, 606/7, 606/2.5, 606/15, 606/10
• US Class Current: 604/22
• CPC Class Codes: A61B 17/2202 the ultrasound transducer being inside patient's body at the distal end of the catheter
• CPC Class Codes: A61B 18/26 for producing a shock wave, e.g. laser lithotripsy
• CPC Class Codes: A61B 2017/00106 ultrasonic
• CPC Class Codes: A61B 2017/22084 stone- or thrombus-dissolving
• CPC Class Codes: A61B 2090/378 using ultrasound

Abstract

This invention is an optically activated transducer for generating acoustic vibrations in a biological medium. The transducer is located at the end of a fiber optic which may be located within a catheter. Energy for operating the transducer is provided optically by laser light transmitted through the fiber optic to the transducer. Pulsed laser light is absorbed in the working fluid of the transducer to generate a thermal pressure and consequent adiabatic expansion of the transducer head such that it does work against the ambient medium. The transducer returns to its original state by a process of thermal cooling. The motion of the transducer within the ambient medium couples acoustic energy into the medium. By pulsing the laser at a high repetition rate (which may vary from CW to 100 kHz) an ultrasonic radiation field can be established locally in the medium. This method of producing ultrasonic vibrations can be used in vivo for the treatment of stroke-related conditions in humans, particularly for dissolving thrombus. The catheter may also incorporate anti-thrombolytic drug treatments as an adjunct therapy and it may be operated in conjunction with ultrasonic detection equipment for imaging and feedback control.

Claims

1. An apparatus for use in a body comprising:

a fiber optic having a proximal end and a distal end; and

an opto-acoustic transducer, a first portion of said transducer fixedly and operatively connected to said distal end of said fiber optic,

wherein at least a second portion of said opto-acoustic transducer vibrates when stimulated by light propagated through said fiber optic, wherein said first and second portions of said transducer are connected wherein the apparatus can be used to disrupt total or partial occlusions within a body lumen.

2. The apparatus of claim 1, further comprising a catheter, wherein said fiber optic is located within said catheter.

3. The apparatus of claim 2, further comprising an adjunct fluid deposition tube located within said catheter, wherein said adjunct fluid deposition tube is for delivery of an adjunct fluid comprising a thrombolytic fluid or a thrombolytic agent.

4. The apparatus of claim 1, further comprising a working fluid within said opto-acoustic transducers wherein said working fluid will expand upon absorption of light.

5. The apparatus of claim 4, wherein said working fluid is selected from a group consisting of water, saline, dyed water, blood and chlorofluorocarbon fluid.

6. The apparatus of claim 4, wherein said working fluid comprises an inert fluid having a low critical point temperature.

7. The apparatus of claim 4, wherein said working fluid comprises an inert fluid having a low critical point temperature within the range of 250 K. to 450 K.

8. The apparatus of claim 4, wherein said opto-acoustic transducer comprises:

a rigid cylinder having a first end and a second end, wherein said first end of said rigid container is fixedly connected to said distal end of said fiber optic; and

a flexible membrane fixedly connected to said second end of said rigid cylinder,

wherein said distal end of said fiber optic and said flexible membrane are sealed to said rigid cylinder to define a confined volume, wherein said flexible membrane allows expansions and contractions of said working fluid within said confined volume to be transmitted to an external medium, and

wherein said working fluid is located within said confined volume.

9. The apparatus of claim 4, wherein said opto-acoustic transducer comprises:

a rigid cylinder having a first end and a second end;

a transparent window fixedly attached to said first end, wherein said fiber optic is optically and fixedly connected to said transparent window; and

a flexible membrane fixedly connected to said second end,

wherein said transparent window and said flexible membrane are sealed to said rigid cylinder to define a confined volume, wherein said flexible membrane allows expansions and contractions of said working fluid within said confined volume to be transmitted to an external medium, and

wherein said working fluid is located within said confined volume.

10. The apparatus of claim 9, wherein said rigid cylinder has a high thermal conductivity.

11. The apparatus of claim 9, wherein said transparent window comprises a transparent dielectric material.

12. The apparatus of claim 11, wherein said transparent dielectric material is selected from a group consisting of glass, sapphire and diamond.

13. The apparatus of claim 11, wherein said transparent dielectric material comprises quartz.

14. The apparatus of claim 1, further comprising a laser to provide said light, wherein said laser produces a high repetition rate laser beam for use as an energy source for said opto-acoustic transducer.

15. The apparatus of claim 14, wherein said laser comprises a gain medium selected from a group consisting of a gaseous gain medium, a liquid gain medium and a solid state gain medium.

16. The apparatus of claim 14, wherein said laser is a rare earth-doped solid state laser.

17. The apparatus of claim 14, wherein said laser is selected from a group consisting of a ruby laser, an alexandrite laser, an Nd:

YAG laser and a Ho;

YLF laser.

18. The apparatus of claim 14, wherein said laser comprises means for producing harmonics of the fundamental lasing wavelength of said laser, wherein said means for producing harmonics are selected from a group consisting of a non-linear frequency-doubling crystal and a non-linear frequency-tripling crystal.

19. The apparatus of claim 2, wherein said catheter comprises a 2.5 French catheter.

20. The apparatus of claim 2, wherein said catheter comprises an endovascular catheter.

21. The apparatus of claim 4, wherein said opto-acoustic transducer comprises a bellows head, wherein said light from a laser source is absorbed by said working fluid within said bellows head, wherein said fluid vaporizes causing a pressure rise and said bellows head expands axially, impinging on an occlusion.

22. The apparatus of claim 21, wherein said bellows head comprises bio-compatible metal.

23. The apparatus of claim 22, wherein said bio-compatible metal is selected from a group consisting of platinum and gold.

24. The apparatus of claim 21, wherein said bellows comprises a non-bio-compatible metal coated with a bio-compatible metal.

25. The apparatus of claim 24, wherein said non-bio-compatible metal is selected from a group consisting of copper and nickel.

26. The apparatus of claim 21, wherein said bellows comprises a metal electroplated over a mandrel to a thickness within the range of 10 μ

m and 100 μ

m.

27. The apparatus of claim 4, wherein said opto-acoustic transducer comprises a nozzle to increase the velocity of ambient fluid flow (e.g., blood) away from the distal end of said fiber optic, wherein said nozzle provides fluid flow in the axial direction.

28. The apparatus of claim 27, further comprising at least one hole in said nozzle, wherein said ambient fluid flow is directed at an oblique angle relative to the axis of said fiber optic.

29. The apparatus of claim 27, wherein said working fluid is selected from a group consisting of water, perfused saline, dyed water, blood, chloro-fluorocarbon fluid and a thrombolytic agent.

30. The apparatus of claim 27, wherein said nozzle comprises material selected from a group consisting of metal and plastic.

31. The apparatus of claim 5, wherein said opto-acoustic transducer comprises:

a rigid cylinder having a first end and a second end; and

a suspended tip which covers said second end of said rigid container, wherein said suspended tip is fixedly connected at a point or segment of said second end such that a portion of said second end is not attached to said suspended tip,

wherein said first end of said rigid cylinder is sealed to said fiber optic, wherein said fiber optic, said rigid cylinder and said suspended tip define a confined volume,

wherein said working fluid is located within said confined volume, and

wherein a laser pulse initiates a thermodynamic cycle in said working fluid which actuates said suspended tip.

32. The apparatus of claim 31, wherein said suspended tip comprises silicon.

33. The apparatus of claim 31, wherein said suspended tip has a flat configuration.

34. The apparatus of claim 31, wherein said suspended tip comprises a shape formed thereon to increase the exertion of force by said suspended tip on a blockage.

35. The apparatus of claim 1, wherein said opto-acoustic transducer comprises a microchannel element fixedly and operatively connected to said distal end of said fiber optic.

36. The apparatus of claim 35, wherein said microchannel element comprises a first side and a second side, wherein said first side comprises fine pitched microchannels operatively and fixedly connected to said fiber optic, wherein said first side is operatively positioned to face and receive said light, wherein said second side comprises a microchannel structure having a surface area that is increased over that of a flat surface, and wherein said second side is configured to enhance the thermal transfer from said light to said working fluid.

37. The apparatus of claim 35, wherein said microchannel element comprises an anisotropically etched {110}-oriented single crystal of silicon, and wherein silicon nitride is deposited on said silicon for use as a masking layer.

38. The apparatus of claim 1, wherein said opto-acoustic transducer comprises a porous silicon element fixedly and operatively connected to said distal end of said fiber optic.

39. The apparatus of claim 9, wherein said confined volume comprises an open structure including a configuration selected from a group consisting of holes and channels.

40. The apparatus of claim 9, wherein said confined volume comprises a porous structure located within said volume to facilitate absorption of energy from said light to shorten the thermal relaxation time constant of said apparatus.

41. The apparatus of claim 9, wherein said fiber optic comprises a 400 μ

m diameter optical fiber and wherein said rigid cylinder comprises titanium.

42. The apparatus of claim 14, wherein said high repetition rate laser beam has a pulse frequency within the range of 10 Hz and 100 kHz.

43. The apparatus of claim 14, wherein said high repetition rate laser beam has a wavelength within the range of 200 nm and 5000 nm.

44. The apparatus of claim 14, wherein said high repetition rate laser beam has a pulse energy density within the range of 0.01 J/cm² to 4 J/cm².

45. The apparatus of claim 14, wherein said high repetition rate laser beam has a pulse duration of less than 200 ns.

46. The apparatus of claim 14, wherein said high repetition rate laser beam has a sinusoidal pulse waveform.

47. The apparatus of claim 14, wherein said high repetition rate laser beam has a pulse duration that is less than 1 μ

s.

48. The apparatus of claim 14, wherein said high repetition rate laser beam has (i) a pulse frequency within the range of 10 Hz to 100 kHz, (ii) a wavelength within the range of 200 nm to 5000 nm, (iii) a pulse energy density within the range of 0.01 J/cm² to 4 J/cm² and (iv) a pulse duration of less than 200 ns.

49. The apparatus of claim 14, wherein said high repetition rate laser beam comprises (i) a pulse frequency within the range of 10 Hz to 100 kHz, (ii) a wavelength within the range of 200 nm to 5000 nm, (iii) a pulse energy density within the range of 0.01 J/cm² to 4 J/cm² and (iv) a sinusoidal pulse waveform.

50. The apparatus of claim 14, wherein said high repetition rate laser beam has (i) a pulse frequency within the range of 10 Hz to 100 kHz, (ii) a wavelength within the range of 200 nm to 5000 nm, (iii) a pulse energy density within the range of 0.01 J/cm² to 4 J/cm² and (iv) a pulse duration that is less than 1 μ

s.