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Electroporation-mediated intravascular delivery

  • US 5,944,710 A
  • Filed: 06/24/1996
  • Issued: 08/31/1999
  • Est. Priority Date: 06/24/1996
  • Status: Expired due to Fees
First Claim
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1. A method for sustained intravascular delivery of a composition to cells of a vessel in a subject, the method comprising:

  • denuding the endothelial lining of a vessel,administering the composition locally to the vessel in the subject;

    applying an electrical impulse directly to cells of the vessel via electroporation by directly contacting the vessel with electrodes, wherein the impulse is of sufficient strength and time for the impulse to cause electroporation of at least one cell in the interior of the vessel such that the composition is delivered into the vessel and is retained in the vessel for sustained, localized delivery.

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