Electroporation-mediated intravascular delivery
First Claim
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1. A method for sustained intravascular delivery of a composition to cells of a vessel in a subject, the method comprising:
- denuding the endothelial lining of a vessel,administering the composition locally to the vessel in the subject;
applying an electrical impulse directly to cells of the vessel via electroporation by directly contacting the vessel with electrodes, wherein the impulse is of sufficient strength and time for the impulse to cause electroporation of at least one cell in the interior of the vessel such that the composition is delivered into the vessel and is retained in the vessel for sustained, localized delivery.
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Abstract
A method for sustained intravascular delivery via electroporation is provided. The method is useful for delivery of therapeutic compositions such as antithrombotic and anticoagulant agents. The invention also provides a catheter apparatus for introducing a composition into at least one cell in a vessel in a subject.
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Citations
18 Claims
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1. A method for sustained intravascular delivery of a composition to cells of a vessel in a subject, the method comprising:
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denuding the endothelial lining of a vessel, administering the composition locally to the vessel in the subject; applying an electrical impulse directly to cells of the vessel via electroporation by directly contacting the vessel with electrodes, wherein the impulse is of sufficient strength and time for the impulse to cause electroporation of at least one cell in the interior of the vessel such that the composition is delivered into the vessel and is retained in the vessel for sustained, localized delivery. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 16, 17, 18)
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15. A method for sustained intravascular delivery of a composition to cells of a vessel in a subject, the method comprising:
- denuding the endothelial lining of a vessel
administering the composition to the vessel of a subject using an apparatus having; a catheter having at least one inflatable balloon portion; at least one infusion passage for introducing the composition into the subject; a first electrode positioned adjacent to at least one infusion passage; a second electrode positioned with respect to the first electrode and the subject such that an electric field sufficient to cause electroporation of at least one cell in the vessel is generated, thereby allowing the composition to enter at least one cell after introduction of the composition through at least one infusion passage; applying an electrical impulse to cells of a vessel in the subject via electroporation, wherein the electrodes are in the vessel and wherein the impulse is of sufficient strength and time for the impulse to cause electroporation of at least one cell in the interior of the vessel such that the composition is delivered locally into the vessel and is retained in the vessel for sustained delivery.
- denuding the endothelial lining of a vessel
Specification