Endovascular electrolytically detachable wire and tip for the formation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas

• US 5,944,714 A
• Filed: 10/06/1997
• Issued: 08/31/1999
• Est. Priority Date: 03/13/1990
• Status: Expired due to Term

• Current Assignee: Regents of the University of California (University of California)
• Original Assignee: Regents of the University of California (University of California)
• Inventors: Sepetka, Ivan, Guglielmi, Guido
• Primary Examiner(s): COHEN, LEE S
• Application Number:
  US08/944,828
• Time in Patent Office: 694 Days
• Field of Search: 606/32, 606/41, 606/49, 606/28, 606/108, 606/191, 606/200, 600/569, 600/585, 604/104, 607/122, 623/1, 623/12
• US Class Current: 606/32
• CPC Class Codes: A61B 17/12022 Occluding by internal devices, e.g. balloons or releasable wires plugging an opening in the wall of an organ A61B17/0057; occluders for the cervical canal A61F6/146; vas deferens occluders A61F6/20
• CPC Class Codes: A61B 17/12113 within an aneurysm
• CPC Class Codes: A61B 17/1214 Coils or wires
• CPC Class Codes: A61B 17/12145 having a pre-set deployed three-dimensional shape methods of manufacturing A61B2017/00526
• CPC Class Codes: A61B 17/1215 comprising additional materials, e.g. thrombogenic, having filaments, having fibers, being coated
• CPC Class Codes: A61B 17/12172 having a pre-set deployed three-dimensional shape methods of manufacturing A61B2017/00526
• CPC Class Codes: A61B 18/1492 having a flexible, catheter-like structure, e.g. for heart ablation A61B18/1477 takes precedence
• CPC Class Codes: A61B 2017/00292 mounted on or guided by flexible, e.g. catheter-like, means
• CPC Class Codes: A61B 2017/12063 electrolytically detachable
• CPC Class Codes: A61B 2017/12095 Threaded connection
• CPC Class Codes: A61B 2017/22038 with a guide wire
• CPC Class Codes: A61B 2018/00678 upper
• CPC Class Codes: A61B 2018/00761 Duration
• CPC Class Codes: A61B 2018/00875 Resistance or impedance
• CPC Class Codes: A61B 2018/00886 Duration
• CPC Class Codes: A61B 2018/1226 powered by a battery
• CPC Class Codes: A61B 2018/1253 monopolar
• CPC Class Codes: A61B 2018/126 bipolar
• CPC Class Codes: A61B 2018/1266 with DC current output
• CPC Class Codes: A61B 2018/1435 Spiral
• CPC Class Codes: A61B 2018/1495 : Electrodes being detachable from a support structure
• CPC Class Codes: A61B 2090/3966 : Radiopaque markers visible in an X-ray image
• CPC Class Codes: A61B 90/39 : Markers, e.g. radio-opaque or breast lesions markers
• CPC Class Codes: A61M 2025/09175 : having specific characteristics at the distal tip
• CPC Class Codes: A61M 25/09 : Guide wires

Abstract

An artery, vein, aneurysm, vascular malformation or arterial fistula is occluded through endovascular occlusion by the endovascular insertion of a platinum wire and/or tip into the vascular cavity. The vascular cavity is packed with the tip to obstruct blood flow or access of blood in the cavity such that the blood clots in the cavity and an occlusion if formed. The tip may be elongate and flexible so that it packs the cavity by being folded upon itself a multiple number of times, or may pack the cavity by virtue of a filamentary or fuzzy structure of the tip. The tip is then separated from the wire mechanically or by electrolytic separation of the tip from the wire. The wire and the microcatheter are thereafter removed leaving the tip embedded in the thrombus formed within the vascular cavity. Movement of wire in the microcatheter is more easily tracked by providing a radioopaque proximal marker on the microcatheter and a corresponding indicator marker on the wire. Electrothrombosis is facilitate by placing the ground electrode on the distal end of the microcatheter and flowing current between the microcatheter electrode and the tip.

Claims

1. A guidewire for use in endovascular electrothrombosis in combination with a microcatheter, the guidewire comprising:

a core wire having a main body and a distal portion; and

a detachable coil for endovascular insertion within a body cavity, said detachable coil being coupled to said main body via said distal portion of said core wire and comprised of material less susceptible to electrolytic disintegration than said core wire, said distal portion being more susceptible to electrolytic disintegration than said detachable coil so that on the application of electric current to the guidewire when said detachable coil is disposed in the cavity, electrothrombosis is performed in the body cavity by said detachable coil and at least one portion of said distal portion is electrolytically disintegrated to detach said detachable coil from said main body to enable the removal of the main body of the core wire whilst leaving the detached coil within the body cavity.

2. The guidewire of claim 1, wherein said distal portion further comprises a disintegratable coil having a distal end and a threadlike extension of the main body of said core wire having a distal end extending concentrically within said disintegratable coil and connected at said distal end of said threadlike extension to a connection between said distal end of the disintegratable coil and said detachable coil, both said threadlike extension and said disintegratable coil electrolytically disintegratable at least at one point in order to detach the detachable coil from the main body.

3. The guidewire of claim 1, wherein only one portion of said distal portion is required to be electrolytically disintegrated in order to detach said detachable coil from said main body.

4. The guidewire of claim 1 wherein said endovascular electrothrombosis is formed in a vascular cavity and wherein said detachable coil has a length sufficient to substantially fill said vascular cavity when disposed therein.

5. The guidewire of claim 1 in combination with a microcatheter, wherein said guidewire is telescopically disposed in said microcatheter, wherein said endovascular electrothrombosis is formed in a vascular cavity and wherein the detachable coil is prebiased to form a helix or spiral when advanced into said vascular cavity out of said microcatheter.

6. The guidewire of claim 5, wherein although prebiased the detachable coil is extremely soft and its overall shape is easily deformed such that, once advanced from a microcatheter into the vascular cavity, it will loosely deform to the interior shape of the vascular cavity.

7. The guidewire of claim 1 wherein the detachable coil is not prebiased.

8. The guidewire of claim 1, wherein said detachable coil has a distal end and wherein said distal end of said detachable coil is provided with a rounded and smooth termination to avoid puncturing the body cavity.

9. The guidewire of claim 1, wherein the main body of the core wire is covered with insulation to prevent the underlying portion of the guidewire from being electrolyzed.

10. The guidewire of claim 1, wherein the distal portion of the core wire is such that, when the detachable coil is disposed in the body cavity and the guidewire is supplied with a current of approximately 0.01 to 2 milliamps at 0.1 to 6 volts, electrolytic disintegration of said at least one portion of the distal portion of the core wire takes place within 10 minutes or less, thereby to detach the detachable coil from the main body of the core wire.

11. The guidewire of claim 1, wherein the body cavity is an intracranial aneurysm.

12. A guidewire for use in electrothrombosis in combination with a microcatheter, the guidewire comprising:

a core wire having a main body and a distal portion ; and

a detachable coil coupled to said main body via said distal portion and comprised of material less susceptible to electrolytic disintegration than said core wire, said detachable coil containing no internal reinforcement and being for insertion within a body cavity;

wherein said distal portion is more susceptible to electrolytic disintegration than said detachable coil, so that on the application of current to the guidewire when said detachable coil is disposed in the body cavity, electrothrombosis is performed and at least one portion of said distal portion is electrolytically disintegrated to detach said detachable coil from said main body.

13. A guidewire for use in electrothrombosis in combination with a microcatheter having a distal end, the guidewire comprising:

a core wire having a main body and a distal portion, said distal portion being susceptible to electrolytic disintegration in blood; and

a detachable coil for insertion within a body cavity, said detachable coil being coupled to said main body via said distal portion, being comprised of material not susceptible to electrolytic disintegration in blood, and being prebiased to a spiral or helical shape such that on its advancement out of the distal end of the microcatheter and into a body cavity it will change from being straight to its prebiased spiral or helical shape so that on the application of current to the guidewire when said detachable coil is disposed in the body cavity, electrothrombosis is performed and at least one portion of said distal portion electrolytically disintegrates to detach said detachable coil from said main body.