Method for preferential outer retinal stimulation

• US 5,944,747 A
• Filed: 03/13/1998
• Issued: 08/31/1999
• Est. Priority Date: 03/13/1998
• Status: Expired due to Term

• Current Assignee: Johns Hopkins University
• Original Assignee: Johns Hopkins University
• Inventors: Humayun, Mark S., Greenberg, Robert J., de Juan, Eugene Jr.
• Primary Examiner(s): Getzow, Scott M.
• Application Number:
  US09/041,932
• Time in Patent Office: 536 Days
• Field of Search: 607/53, 607/54
• US Class Current: 607/54
• CPC Class Codes: A61N 1/36046 of the eye

Abstract

A method of focused phosphene generation through deeper intermediate retinal cellular electrical stimulation to the exclusion of direct ganglion cellular electrical stimulation comprises the steps of: a) positioning a stimulating electrode in the vicinity of retinal tissue; and b) applying a long duration stimulation signal to the electrode such that deeper intermediate retinal cells are preferentially stimulated over the retinal ganglion cells and proximal overlying surface axons. The long duration stimulation signal is preferably a biphasic signal having a negative and a positive phase pulse which is applied in cathodic fashion. To preferentially stimulate the deeper intermediate retinal elements the duration of the long duration stimulation signal is greater than 0.5 millisecond per phase pulse, and preferably equal to or longer than 2 millisecond per phase pulse. The biphasic signal is preferably adjusted to simulate a monophasic signal by adjusting the magnitude of the negative pulse in relation to positive pulse, and by adjusting the duration of the positive pulse in relation to the negative pulse to maintain approximately net zero charge introduction. Preferably, the ratio of the negative pulse to the positive pulse is approximately 10:1 or greater.

Claims

1. A method of focused phosphene generation in retinal tissue through deeper intermediate retinal cellular electrical stimulation to the exclusion of direct ganglion cellular electrical stimulation comprising the steps of:

positioning at least one stimulating electrode in the vicinity of retinal tissue; and

applying a long duration stimulation signal to the at least one electrode such that deeper intermediate retinal cells are preferentially stimulated over the retinal ganglion cells and proximal overlying surface axons.

2. The method of claim 1, wherein the long duration stimulation signal is a biphasic signal having a negative and a positive phase pulse.

3. The method of claim 2, wherein said step of applying a long duration stimulation signal comprises the step of applying the long duration stimulation signal in cathodic fashion.

4. The method of claim 2, wherein the duration of the long duration stimulation signal is greater than about 0.5 millisecond per phase pulse.

5. The method of claim 2, wherein the duration of the long duration stimulation signal is greater than or equal to about 2 millisecond per phase pulse.

6. The method of claim 2, wherein the duration of the long duration stimulation signal is greater than about 4 millisecond per phase pulse.

7. The method of claim 2, wherein the duration of the long duration stimulation signal is greater than about 8 millisecond per phase pulse.

8. The method of claim 2, wherein said step of applying a long duration stimulation signal comprises the step of applying a train of said biphasic signals.

9. The method of claim 2, wherein said biphasic signal includes an intra-pulse delay.

10. The method of claim 9, wherein said intra-pulse delay is in relation to a duration of said negative pulse.

11. The method of claim 9, wherein said intra-pulse delay is in the range of about 1 to 4 millisecond.

12. The method of claim 2, wherein said step of applying a long duration stimulation signal comprises the step of adjusting said biphasic signal to simulate a monophasic signal.

13. The method of claim 12, wherein said step of adjusting said biphasic signal comprises the steps of:

adjusting a magnitude of said negative pulse in relation to said positive pulse; and

adjusting a duration of said positive pulse in relation to said negative pulse to maintain approximately net zero charge introduction.

14. The method of claim 13, wherein said step of adjusting a magnitude of said negative pulse in relation to said positive pulse increases the magnitude of the negative pulse by a ratio of approximately 10:

1 to the positive pulse.

15. The method of claim 1, wherein the long duration stimulation signal is a periodic waveform having a frequency less than or equal to about 50 hertz.

16. The method of claim 1, wherein the long duration stimulation signal has a duration and a magnitude selected to preclude inadvertent stimulation of retinal ganglion cells.

17. A method of preferentially stimulating intermediate retinal elements comprising the steps of:

positioning a stimulating electrode in proximity to retinal tissue; and

applying a biphasic stimulation signal having a duration greater than about 0.5 milliseconds to the electrode.

18. The method of claim 17, wherein said duration is greater than or equal to about 2 milliseconds.

19. The method of claim 18, wherein said step of applying a biphasic stimulation signal comprises the step of applying a biphasic stimulation signal in a cathodic fashion.

20. A method of producing focused phosphenes in retinal tissue comprising the steps of:

positioning a stimulating electrode in proximity to retinal tissue; and

generating a biphasic stimulation signal having a negative and a positive pulse and including an intra-pulse delay therebetween, each of said pulses having a duration greater than or equal to about 2 milliseconds and a magnitude, said biphasic stimulation signal having a relationship between said magnitude and said duration of said negative and said positive pulses such that the total charge supplied is approximately zero; and

applying said biphasic stimulation signal to the electrode in a cathodic fashion.