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Controlled release tablet

  • US 5,945,125 A
  • Filed: 06/21/1996
  • Issued: 08/31/1999
  • Est. Priority Date: 02/28/1995
  • Status: Expired due to Term
First Claim
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1. A controlled release tablet consisting essentially of a single homogeneous mixture of a pharmaceutical agent selected from the group consisting of nifedipine, diclofenac sodium, salicylic acid, theophylline anhydrous, sulfapyridine, sulfadrazine, propranolol hydrochloride, diltiazem hydrochloride, glipizide, and sulfathiazole, a solubilizing agent, and an excipient, wherein said excipient comprises:

  • polyethylene oxide and a lubricant; and

    wherein the pharmaceutical agent is released from the tablet at a rate expressed as Mt /MT =ktn where;

    t is time,Mt is the amount of the pharmaceutical agent which has been released at time t,MT is the total amount of the pharmaceutical agent contained in the tablet,k is a constant, andn is the release kinetics exponent; and

    wherein the molecular weight and the solubility, respectively, of said polyethylene oxide and the pharmaceutical agent are selected such that n is about 0.89 to 1.0.

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