Storage-stable drug form

• US 5,945,127 A
• Filed: 09/16/1997
• Issued: 08/31/1999
• Est. Priority Date: 03/21/1995
• Status: Expired due to Term

• Current Assignee: Abbvie Deutschland GmbH & Company KG (Abbvie Incorporated)
• Original Assignee: BASF AG (BASF SE)
• Inventors: Breitenbach, Jorg, Sanner, Axel, Rosenberg, Joerg, Rieger, Jens
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): Benston, Jr., William E.
• Application Number:
  US08/913,513
• Time in Patent Office: 714 Days
• Field of Search: 424/489, 424/465, 424/488
• US Class Current: 424/489
• CPC Class Codes: A61K 9/1635 obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
• CPC Class Codes: A61K 9/1652 Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin homeopathic globules A61K9/1623
• CPC Class Codes: A61K 9/1694 resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Abstract

Solid drug forms obtainable by extrusion of a melt comprising, besides one or more active substances, a mixture of homo- and/or copolymers of N-vinylpyrrolidone and degraded starches.

Claims

1. A solid drug form obtained by extruding of a solvent-free melt comprising, besides one or more active substances, a mixture of

a) 10-99% by weight of one or more water-soluble, melt-processable, homo- or copolymers of N-vinylpyrrolidone,

b) 1-90% by weight of degraded starches, and

c) 0-50% by weight of one or more conventional pharmaceutical ancillary substances,

and subsequent shaping.

2. A drug form as defined in claim 1, comprising maltodextrins as components b).

3. A drug form as defined in claim 1, having an active substance content of from 0.1 to 90% by weight.

4. A solid drug form as defined in claim 1, wherein component a) is present in an amount of 40-95% by weight and component b) is present in an amount of 5-60% by weight.

5. A solid drug form as defined in claim 4, wherein the active substance content is from 0.5 to 60% by weight.