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Protein-colloidal metal-aminodextran coated particle and methods of preparation and use

  • US 5,945,293 A
  • Filed: 10/09/1997
  • Issued: 08/31/1999
  • Est. Priority Date: 10/09/1997
  • Status: Expired due to Fees
First Claim
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1. A stable colloidal particle comprising:

  • (a) a colloidal-sized core substrate having amine-reactive functional groups thereon;

    (b) an aminodextran coating over the peripheral surface of said substrate;

    (c) a layer of colloidal-sized metallic solid overlaying said aminodextran coating, wherein the metal for said metallic solid is selected from the group consisting of metals which can be reduced from the ionic state to the metal(0) state by the aminodextran coating of said core;

    (d) an aminotrithiolate linker attached to said metallic solid, said linker having a free amino group; and

    (e) a protein attached to said linker by covalently bonding to said free amino group.

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