Amino ceramide-like compounds and therapeutic methods of use
First Claim
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1. A vaccination method comprising the steps of:
- a) removing cancer cells sensitive to the compounds below, from a patient;
b) treating the cancer cells in vitro with an effective amount of a compound selected from the group consisting of compounds of the formula;
##STR5## where R1 is an aromatic structure, an alicyclic structure, a branched aliphatic structure or a linear aliphatic group having 5 to 15 carbons;
R2 is an aliphatic chain having 9 to 18 carbons; and
R3 is pyrrolidino; and
functional homologues, isomers and pharmaceutically acceptable salts thereof; and
c) administering the treated cells to the patient.
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Abstract
Novel amino ceramide-like compounds are provided which inhibit glucosyl ceramide (GlcCer) formation by inhibiting the enzyme GlcCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer sythase inhibition activity and are therefore highly useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.
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Citations
5 Claims
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1. A vaccination method comprising the steps of:
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a) removing cancer cells sensitive to the compounds below, from a patient; b) treating the cancer cells in vitro with an effective amount of a compound selected from the group consisting of compounds of the formula;
##STR5## where R1 is an aromatic structure, an alicyclic structure, a branched aliphatic structure or a linear aliphatic group having 5 to 15 carbons;R2 is an aliphatic chain having 9 to 18 carbons; and R3 is pyrrolidino; and
functional homologues, isomers and pharmaceutically acceptable salts thereof; andc) administering the treated cells to the patient. - View Dependent Claims (2, 3, 4, 5)
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Specification