Fixed optic sensor system and distributed sensor network

• US 5,946,083 A
• Filed: 10/01/1997
• Issued: 08/31/1999
• Est. Priority Date: 10/01/1997
• Status: Expired due to Term

• Current Assignee: Texas Instruments, Inc.
• Original Assignee: Texas Instruments, Inc.
• Inventors: Breedlove, Paul S., Bartholomew, Dwight U., Carr, Richard A., Melendez, Jose L., Berlien, John H. Jr., Geyer, Frederick F., Smith, Patrick Paul
• Primary Examiner(s): Font, Frank G.
• Assistant Examiner(s): Ratliff, Reginald A.
• Application Number:
  US08/942,563
• Time in Patent Office: 699 Days
• Field of Search: 356/73, 356/39, 356/317
• US Class Current: 356/73
• CPC Class Codes: A61B 5/0022 Monitoring a patient using a global network, e.g. telephone networks, internet
• CPC Class Codes: G01N 21/553 and using surface plasmons fluorescence excitation G01N21/648; enhanced Raman G01N21/658
• CPC Class Codes: G01N 21/6428 Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" in vivo A61B5/00; immunoassay G01N33/53

Abstract

A fixed optic sensor system (200) comprising a sensor system (210), and electronic sub-system (205) and a communications means (215). The system can be used for detecting the presence of various sample (236) properties and in that regard has widespread application by leveraging off various miniaturized sensor configurations including surface plasmon resonance (50), fluorescence (80), light transmission (125) and others (150). In one embodiment, the communications means (215) is a wireless transmitter/receiver. In another embodiment, a hand held instrument (358) can be used on-site and communicates with the sensor (350) to receive sample (352) related data and transmit it to a remote processing system (370) for further analysis. In yet another embodiment, a hand held instrument (403) has a plurality of cardiac marker binding ligands (400) deposited on the sensor/sample interface providing a medical diagnosis and point-of-care device (403).

Claims

1. A distributed sensor network comprising:

a first group of miniaturized integrated sensors predisposed about a first sample region, each sensor designated by a unique sensor identification tag belonging to the first group;

a second group of miniaturized integrated sensors predisposed about a second sample region, each sensor designated by a unique sensor identification tag belonging to the second group;

first and second local processing systems communicably linked to said first and second groups of sensors for receiving data relating to said first and second sample regions; and

a centralized processing system communicably linked to said first and second processing systems via a network.

2. The distributed sensor network in accordance with claim 1 wherein said sensors of at least one of said first and second groups have a sensing surface in contact with a sample analyte and at least one light source and one detector interfaced in fixed relation to said sensing surface.

3. The distributed sensor network in accordance with claim 2 wherein at least one of said first and second processing systems includes an on-board signal processor, storage area, user interface and display functionally interfaced with one another to process, store and display information relating to said sample analyte.

4. The distributed sensor network in accordance with claim 3 wherein said at least one processing system further comprises:

an on-board power source operably coupled to said processor, storage area, user interface and display for providing operational power;

a static memory area operably coupled to said processor; and

software embedded in said static memory area and providing a plurality of user control and sample-related functions for operating said at least one processing system and for analyzing and displaying sample related results.

5. The distributed sensor network in accordance with claim 3 wherein said signal processor is an on-board microprocessor circuit and the network further includes an on-board analog-to-digital converter circuit communicably coupled to sensors of at least one of said first and second groups for receiving sample-related analog data, converting it to its digital bitstream form and relaying said digital bitstream to said microprocessor circuit for further processing.

6. The distributed sensor network in accordance with claim 3 wherein said first and second local processing systems are communicably linked to said first and second groups of sensors via wireless radio frequency communications systems.

7. The distributed sensor network in accordance with claim 3 wherein at least one of said first and second local processing systems is self-contained in a hand-held instrument enclosure.

8. The distributed sensor network in accordance with claim 1 wherein said sensors of at least one of said first and second groups is a surface plasmon resonance (SPR) sensor having an SPR layer.

9. The distributed sensor network in accordance with claim 1 wherein said sensors of at least one of said first and second groups is a fluorescence-based sensor.

10. The distributed sensor network in accordance with claim 8 wherein at least one of said first and second local processing systems is self-contained in a hand-held instrument enclosure and wherein the SPR layer of a sensor corresponding to said at least one local processing system is coated with one or more binding ligands.

11. The distributed sensor network in accordance with claim 1 wherein said first and second local processing systems are each communicably coupled to said network via a communications system selected from the group consisting of radio frequency communications system, satellite communications system, infrared communications system and physical link.

12. The distributed sensor network in accordance with claim 1 wherein said centralized processing system is selected from the group consisting personal computer workstation, mini-computer and mainframe computer.