Drug delivery system
First Claim
1. A drug delivery system, comprising:
- a drug housing having a medicament receiving chamber with a first, open end mountable in fluid tight communication with a biologic material and a second end; and
a drug delivery initiator including;
a first, proximal chamber that is selectively gas impermeable, said first chamber being configured to receive pressurized gas;
a second, distal chamber having an opening at a distal end thereof adjacent to the second end of the drug housing; and
a rapidly openable divider disposed between the first and second chambers, and effective upon opening to propagate a shock wave through said distal chamber to said second end of the drug housing.
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Accused Products
Abstract
A drug delivery system includes a container having proximal and distal ends and a rapidly openable divider, replaceably disposed within the container to separate the container into a proximal chamber that is selectively gas impermeable and able to receive a pressurized gas and a distal chamber having an opening at a distal end thereof. A membrane is disposed between the opening in the distal chamber of the container and a biologic material, such as a patient'"'"'s skin, treated with a medicament. In operation, rapid opening of the divider causes a shock wave to be generated and transmitted through the opening in the distal chamber to impinge on the membrane which transfers the shock wave to the biologic material. The system may further include a drug housing mountable in a fluid tight manner on the biologic material and an optional sealing element by which the fluid tight seal is created.
57 Citations
48 Claims
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1. A drug delivery system, comprising:
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a drug housing having a medicament receiving chamber with a first, open end mountable in fluid tight communication with a biologic material and a second end; and a drug delivery initiator including; a first, proximal chamber that is selectively gas impermeable, said first chamber being configured to receive pressurized gas; a second, distal chamber having an opening at a distal end thereof adjacent to the second end of the drug housing; and a rapidly openable divider disposed between the first and second chambers, and effective upon opening to propagate a shock wave through said distal chamber to said second end of the drug housing. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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25. A shock wave generating system, comprising:
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a container having proximal and distal ends; and a rapidly openable divider replaceably disposed within the container to separate the container into a proximal chamber that is selectively gas impermeable and configured to receive a pressurized gas, and a distal chamber having an opening at a distal end thereof for placement at a target material, said divider being effective to generate a shock wave when rapidly opened such that the shock wave is transmitted through the distal chamber to the target material. - View Dependent Claims (26, 27, 28, 29, 30, 31)
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32. A drug delivery system, comprising:
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a container; a rapidly openable divider disposed within the container so as to divide the container into a first, proximal chamber that is selectively gas impermeable and is configured to receive a pressurized gas, and a distal chamber having an opening at a distal end thereof through which a shock wave is transmitted upon rapid opening of the divider; and a gas permeable membrane having a first surface that receives the shock wave and a second, opposed surface that transmits the shock wave received by the first surface to a target material. - View Dependent Claims (33, 34, 35, 36, 37, 38)
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39. A method of administering a drug, comprising the steps of:
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providing a drug to a biologic material; providing a container having a rapidly openable divider disposed therein so as to divide the container into a first, proximal chamber that is selectively gas impermeable and is configured to receive a pressurized gas, and a distal chamber having an opening at a distal end thereof; and rapidly opening the divider so as to release pressurized gas from the first chamber and create a shock wave which propagates through the second chamber and the opening of the distal end of the second chamber to the biologic material whereby the drug enters the biological material. - View Dependent Claims (40, 41, 42, 43, 44, 45, 46, 47, 48)
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Specification