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Pharmaceutical formulations having improved disintegration and/or absorptivity

  • US 5,948,438 A
  • Filed: 06/04/1997
  • Issued: 09/07/1999
  • Est. Priority Date: 01/09/1995
  • Status: Expired due to Fees
First Claim
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1. An oral solid dosage form, comprisinga compressed tablet including an excipient comprising (a) microcrystalline cellulose;

  • and (b) a compressibility augmenting agent which (i) physically restricts the proximity of the interface between adjacent cellulose surfaces;

    or (ii) inhibits interactions between adjacent cellulose surfaces;

    or (iii) accomplishes both (i) and (ii) above;

    said composition comprising agglomerated particles of said microcrystalline cellulose and said compressibility augmenting agent in intimate association with each other; and

    a therapeutically active agent.

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