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Method for size separation of particles

  • US 5,948,441 A
  • Filed: 01/03/1995
  • Issued: 09/07/1999
  • Est. Priority Date: 03/07/1988
  • Status: Expired due to Term
First Claim
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1. A method of producing nonliposomal lipid particles of a homogeneous, defined size distribution from a mixture of lipid particles of heterogeneous size comprising the steps of:

  • (a) subjecting the mixture to tangential flow filtration with a first filter of a first pore size;

    (b) subjecting the filtrate from step (a) to tangential flow filtration with a second filter of a second, smaller pore size; and

    (c) collecting the retentate from step (b),wherein the first pore size defines the upper limit of the size distribution of the liposomes or lipid particles, the first pore size is between about 10 and about 0.2 microns, the second pore size defines the lower limit of size distribution of the particles and the second pore size is between about 2000 molecular weight and about 2 microns.

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