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Conjugates useful in the treatment of prostate cancer

  • US 5,948,750 A
  • Filed: 10/14/1997
  • Issued: 09/07/1999
  • Est. Priority Date: 10/30/1996
  • Status: Expired due to Fees
First Claim
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1. A conjugate which is useful for the treatment of prostate cancer which comprises a cytotoxic agent attached to an oligopeptide, wherein the oligopeptide comprises a sequence of amino acids that is selectively proteolytically cleaved by free prostate specific antigen and wherein the means of attachment is a covalent bond or through a chemical linker, said sequence of amino acids which comprises at least one cyclic amino acid having a hydrophilic substituent;

  • or the pharmaceutically acceptable salt thereof.

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