Method for detecting brain microhemorrhage

• US 5,951,476 A
• Filed: 11/14/1997
• Issued: 09/14/1999
• Est. Priority Date: 11/14/1997
• Status: Expired due to Term

• Current Assignee: Washington University In St Louis
• Original Assignee: Washington University In St Louis
• Inventors: Beach, Kirk Watson
• Primary Examiner(s): Getzow, Scott M.
• Assistant Examiner(s): MANTIS MERCADER, ELENI M
• Application Number:
  US08/970,972
• Time in Patent Office: 669 Days
• Field of Search: 600/437, 600/448, 600/451, 600/453, 600/455
• US Class Current: 600/437
• CPC Class Codes: A61B 8/0808 for diagnosis of the brain
• CPC Class Codes: A61B 8/0816 using echo-encephalography

Abstract

Continued bleeding into a pocket or hematoma in the cranium could exert pressure on the brain which would move it relative to the cranium to force the brain stem into the medulla oblongata to arrest breathing. Such brain micromovement is detected by projecting bursts of ultrasound into one or both of the temple areas of the cranium or into the medulla oblongata, and the readout of echoes received from different depths is displayed on a screen. The readout of the echoes indicates continued microshifts of the brain relative to the cranium. To differentiate microshifts of the brain relative to the cranium caused by continued intracranial bleeding as distinguished from pulsations of the brain relative to the cranium caused by supply of blood to the brain from the heart and return of blood from the brain to the heart, the timing of the bursts of ultrasound into the cranium is synchronized with the pulse indicated by a heart pulse monitor.

Claims

1. In the process of medically examining a person'"'"'s head by projecting ultrasound into the head, the improvement comprising detecting abnormal very slow progressive brain displacement relative to the cranium over a period of a few minutes caused by continuing intracranial bleeding, by transmitting a series of successive ultrasound bursts separated by short delays into the head for a period of a few minutes, including a first burst of ultrasound into the head along a predetermined path, detecting a first echo pattern composed of ultrasound of the first burst reflected from brain at different depths along such predetermined path corresponding to different selected time intervals after transmission of the first burst, after a short delay transmitting a second burst of ultrasound into the head along the same predetermined path as the first burst, detecting a second echo pattern produced by ultrasound of the second burst reflected from brain at the same different depths along such predetermined path as used in producing the first burst echo pattern by utilizing the same different time intervals after transmission of the second burst as used in detecting the first echo pattern, and comparing the second echo pattern resulting from the second burst with the first echo pattern resulting from the first burst for determining any chance indicating abnormal displacement of brain relative to the cranium lengthwise of the ultrasound predetermined path between the first and second bursts of ultrasound.

2. In the process defined in claim 1, the short delay between the first and second bursts of ultrasound is within the range of 0.25 second to 2.0 seconds.

3. In the process defined in claim 1, synchronizing each burst of ultrasound with the patient'"'"'s electrocardiogram to differentiate abnormal progressive nonpulsatile brain displacement relative to the cranium from normal swelling and contraction pulsation of the brain during heart systole and diastole.

4. In the process defined in claim 1, each echo pattern includes echoes from brain within the range of four to thirty-two different depths.

5. In the process defined in claim 1, each of the series of bursts of ultrasound produces an echo pattern, and displaying all of the echo patterns of the series simultaneously on a readout.

6. In the process defined in claim 5, displaying in the readout the representation of echoes from different predetermined depths along the predetermined path as abscissae of a graph so that successive abscissae collectively form upright lines.

7. In the process defined in claim 1, the number of ultrasound bursts in the series is selected from the group consisting of 128 bursts, 256 bursts, 512 bursts, and 1024 bursts.

8. In the process defined in claim 1, transmitting the bursts of ultrasound into the head through a location of the cranium selected from the group consisting of the left temporal region, the right temporal region and the foramen magnum region.

9. In the process defined in claim 8 transmitting successive bursts of ultrasound into the head alternately through the left temporal region and through the right temporal region.

10. In the process defined in claim 8 used for quantifying the velocity of brain stem relative to the foramen magnum, transmitting the bursts of ultrasound into the head in the region of the foramen magnum, and comparing the second echo pattern and the first echo pattern for indicating abnormal progressive displacement of the brain stem relative to the foramen magnum caused by continuing intracranial bleeding.

11. In the process defined in claim 1, quantifying velocity of very slow abnormal displacement of the brain relative to the cranium by detecting the echo patterns of the ultrasound bursts, and combining the extent of any brain displacement relative to the cranium during such period of a few minutes with such period of a few minutes to determine the average brain velocity relative to the cranium during a unit of time.