Stable hydroalcoholic compositions
First Claim
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1. A hydroalcoholic composition comprising:
- a) a lower alcohol and water in a weight ratio of about 35;
65 to about 95.5; and
b) a thickener system present in an amount of about 0.5% by weight to about 8% by weight, based on the total weight of the composition;
wherein the thickener system comprises at least two solid emulsifiers, each in an amount of at least about 0.05% by weight, based on the total weight of the composition;
wherein at least one emulsifier comprises;
(i) at least one hydrophobic group selected from the group consisting of;
(A) an alkyl group of at least 16 carbon atoms;
(B) an alkenyl group of at least 16 carbon atoms; and
(C) an aralkyl or an aralkenyl group of at least 20 carbon atoms; and
(ii) at least one hydrophilic group selected from the group consisting of;
(A) an amide group;
(B) a short chain ester of a long chain alcohol or acid;
(C) a polyglucoside group having 1-10 glucose units;
(D) a polyglycerol ester group having 1-15 glycerol units;
(E) a secondary amine group;
(F) a tertiary amine group;
(G) a quaternary amine group;
(H) an anionic group;
(I) a zwitterionic group; and
(J) combinations of these groups;
wherein the composition has a viscosity of at least about 4,000 centipoise at 23 °
C. in the absence of polymeric thickeners.
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Abstract
Disclosed is a composition including a lower alcohol and water in a weight ratio of about 35:65 to 100:0, between at least 0.5% and 8.0% by weight thickener system comprised of at least two emulsifiers, each emulsifier present in at least 0.05% by weight wherein the composition free of auxiliary thickeners has a viscosity of at least 4,000 centipoise at 23 degrees C. and wherein each emulsifier is comprised of at least one hydrophobic group and at least one hydrophilic group. The composition is useful as a presurgical scrub replacement, a lotion or other hand preparation.
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Citations
80 Claims
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1. A hydroalcoholic composition comprising:
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a) a lower alcohol and water in a weight ratio of about 35;
65 to about 95.5; andb) a thickener system present in an amount of about 0.5% by weight to about 8% by weight, based on the total weight of the composition;
wherein the thickener system comprises at least two solid emulsifiers, each in an amount of at least about 0.05% by weight, based on the total weight of the composition;
wherein at least one emulsifier comprises;(i) at least one hydrophobic group selected from the group consisting of; (A) an alkyl group of at least 16 carbon atoms; (B) an alkenyl group of at least 16 carbon atoms; and (C) an aralkyl or an aralkenyl group of at least 20 carbon atoms; and (ii) at least one hydrophilic group selected from the group consisting of; (A) an amide group; (B) a short chain ester of a long chain alcohol or acid; (C) a polyglucoside group having 1-10 glucose units; (D) a polyglycerol ester group having 1-15 glycerol units; (E) a secondary amine group; (F) a tertiary amine group; (G) a quaternary amine group; (H) an anionic group; (I) a zwitterionic group; and (J) combinations of these groups; wherein the composition has a viscosity of at least about 4,000 centipoise at 23 °
C. in the absence of polymeric thickeners. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62)
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63. A hydroalcoholic composition comprising:
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a) a lower alcohol and water in a weight ratio of about 35;
65 to about 95;
5;b) a thickener system present in an amount of about 0.5% by weight to about 8% by weight, based on the total weight of the composition;
wherein the thickener system comprises at least two emulsifiers, each in an amount of at least about 0.05% by weight, based on the total weight of the composition;wherein at least one emulsifier comprises; (i) at least one hydrophobic group selected from the group consisting of; (A) an alkyl group of at least 16 carbon atoms; (B) an alkenyl group of at least 16 carbon atoms; and (C) an aralkyl or an aralkenyl group consisting of at least 20 carbon atoms; and (ii) at least one hydrophilic group selected from the group of; (A) an amide group; (B) a short chain ester of a long chain alcohol or acid; (C) a polyglucoside group having 1-10 glucose units; (D) a polyglycerol ester group having 1-15 glycerol units; (E) a secondary amine group; (F) a tertiary amine group; (G) a quaternary amine group; (H) an anionic group; (I) a zwitterionic group; and (J) combinations of these groups; and wherein at least one emulsifier comprises; (i) at least one hydrophobic group selected from the group of; (A) an alkyl group of at least 16 carbon atoms; (B) an alkenyl group of at least 16 carbon atoms; and (C) an aralkyl or an aralkenyl group consisting of at least 20 carbon atoms; and (ii) at least one hydrophilic group selected from the group of; (A) an ethylene oxide- and/or propylene oxide-containing group, which is bonded to the hydrophobic group through an ether or ester bond and optionally terminated with a (C1-C36)alkyl ester, (C2-C36)alkenyl ester, or (C6-C36)alkaryl ester; (B) an alcohol group; (C) a polyhydric alcohol group; (D) an ester or ether group consisting of a polyhydric alcohol or polyalkoxylated derivative thereof; (E) an ester or ether group of sorbitan or polyalkoxylated derivative thereof; and (F) combinations of these groups; and c) an antimicrobial agent distinct from the lower alcohol; wherein the composition has a melt temperature of greater than about 35°
C. and the at least two emulsifiers provide the composition with a viscosity of at least about 4,000 centipoise at 23°
C. - View Dependent Claims (64, 65, 66)
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67. A method of preparing a stable hydroalcoholic composition, the method comprising:
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a) preparing a thickener system comprising at least two emulsifiers, each in an amount of at least about 0.05% by weight, based on the total weight of the composition;
wherein at least one emulsifier comprises;(i) at least one hydrophobic group selected from the group consisting of; (A) an alkyl group of at least 16 carbon atoms; (B) an alkenyl group of at least 16 carbon atoms; and (C) an aralkyl or an aralkenyl group of at least 20 carbon atoms; and (ii) at least one hydrophilic group selected from the group consisting of; (A) an amide group; (B) a short chain ester of a long chain alcohol or acid; (C) a polyglucoside group having 1-10 glucose units; (D) a polyglycerol ester group having 1-15 glycerol units; (E) a secondary amine group; (F) a tertiary amine group; (G) a quaternary amine group; (H) an anionic group; (I) a zwitterionic group; and (J) combinations of these groups; and b) combining the thickener system with a solvent system at a temperature sufficient to melt the thickener system and form a composition having a viscosity of at least about 4,000 centipoise at 23°
C. in the absence of polymeric thickeners;
wherein the solvent system comprises a lower alcohol and water in a weight ratio of about 35;
65 to about 95;
5. - View Dependent Claims (68, 69, 70, 71, 72, 73, 78)
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74. A method of preparing a stable hydroalcoholic composition, the method comprising:
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a) heating a thickener system to a temperature sufficient to melt it;
the thickener system comprising at least two emulsifiers, each in an amount of at least about 0.05% by weight, based on the total weight of the composition;
wherein at least one emulsifier comprises;(i) at least one hydrophobic group selected from the group consisting of; (A) an alkyl group of at least 16 carbon atoms; (B) an alkenyl group of at least 16 carbon atoms; and (C) an aralkyl or an aralkenyl group of at least 20 carbon atoms; and (ii) at least one hydrophilic group selected from the group consisting of; (A) an amide group; (B) a short chain ester of a long chain alcohol or acid; (C) a polyglucoside group having 1-10 glucose units; (D) a polyglycerol ester group having 1-15 glycerol units; (E) a secondary amine group; (F) a tertiary amine group; (G) a quaternary amine group; (H) an anionic group; (I) a zwitterionic group; and (J) combinations of these groups; and b) heating water to a temperature above the melt temperature of the thickener system; c) combining the thickener system and the water; and d) adding a lower alcohol to the thickener system and water to form a composition having a viscosity of at least about 4,000 centipoise at 23°
C. in the absence of polymeric thickeners;
wherein the lower alcohol and water are present in a weight ratio of about 35;
65 to about 95;
5. - View Dependent Claims (75, 76, 77, 79, 80)
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Specification