Method and apparatus for invasively measuring cardiac output by detecting temperature differences of blood heated by radiation

• US 5,954,659 A
• Filed: 02/16/1996
• Issued: 09/21/1999
• Est. Priority Date: 02/16/1996
• Status: Expired due to Fees

• Current Assignee: Michael G. Curley, William H. Newman
• Original Assignee: Michael G. Curley, William H. Newman
• Inventors: Curley, Michael G., Newman, William H.
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): LAYNO, CARL HERNANDZ
• Application Number:
  US08/602,916
• Time in Patent Office: 1,313 Days
• Field of Search: 128/691, 128/692, 128/69.5, 128/664-667, 600/504, 600/505, 600/508, 600/473, 600/474, 600/476, 600/477, 600/479, 600/480
• US Class Current: 600/505
• CPC Class Codes: A61B 5/028 by thermo-dilution

Abstract

A cardiac output measurement device volumetrically heating a predefined quantity of blood flowing through a heart by arbitrarily applying a containable energy field to the blood using a thermodilution catheter having an emitter that uniformly emits electromagnetic radiation. Blood temperature is measured at the pulmonary artery by a sensor that provides a signal representing the temperature of the mixed blood to a controller. The controller determines the flow rate, or cardiac output, by performing a heat balance analysis based upon the applied power and resultant blood temperature. The cardiac output measurement device includes a catheter having an emitter and, preferably, a temperature sensor located at its distal end. The catheter is coupled to a laser or other energy source capable of generating containable electromagnetic radiation, such as an ultraviolet or microwave energy source. Significantly, for the preferred laser source, the emitter is a diffuser that uniformly emits the laser-generated energy into a predetermined volume of flowing blood. A temperature measuring system of the controller receives temperature signals from the sensor and generates a resultant temporal temperature profile used by a flow estimator to determine the flow rate and generate a power excitation function to control the energy source. The resultant measured flow may also be presented though a user interface.

Claims

1. A cardiac output measurement system, comprising:

a catheter adapted to be inserted through an atrium of a heart;

an emitter disposed in said catheter for emitting radiation to volumetrically heat a definable volume of blood that passes through said atrium, said radiation being absorbed by the blood and converted into heat;

a temperature sensitive element disposed downstream from said emitter for generating a signal corresponding to the temperature of the blood downstream from said emitter; and

control means for controlling the application of said radiation.

2. The system of claim 1, wherein said temperature sensitive element is wholly disposed within said catheter.

3. The system of claim 1, further comprising:

a second catheter, wherein said temperature sensitive element is disposed within said second catheter.

4. The system of claim 1 wherein said control means comprises:

a temperature measurement system coupled to said temperature sensitive element for generating a temperature profile of blood based on the signal received from said temperature sensitive element; and

a flow estimator coupled to said temperature measurement system for estimating the flow of blood.

5. The system of claim 1

including an energy source generating electrical energy in the frequency range of 1 MHz to 100MHz, and

wherein said emitter comprises a transducer capable of converting said electrical energy to vibrational energy and acoustically radiating said vibrational energy within said volume of blood.

6. The system of claim 1 wherein said catheter further comprises a second temperature sensitive element disposed upstream from said emitter for generating a signal corresponding to the temperature of the blood upstream from said emitter.

7. The system of claim 1

including an energy source for generating electromagnetic radiation;

and

wherein said emitter comprises an electromagnetic diffuser capable of distributing the electromagnetic radiation substantially uniformly across the length and around circumference of said diffuser.

8. The system of claim 7, wherein said electromagnetic radiation is ultraviolet light having a wavelength in the range of 1×

10⁸ to 4×

10^-7 meters.

9. The system of claim 7, where the electromagnetic radiation is visible light having a wavelength in the range of 4×

10^-7 to 7×

10^-7 meters.

10. The system of claim 7 wherein the electromagnetic radiation is infrared light having a wavelength in the range of 7×

10^-7 to 1×

10^-3 meters.

11. The system of claim 7 wherein said electromagnetic radiation has a microwave frequency in the range of 1×

10⁸ to 3×

10¹¹ Hz.

12. A catheter for use in a cardiac measurement system having an energy source, comprising:

an elongated member configured to be inserted through an atrium of the heart;

an emitter disposed in said member and using energy from said source to emit radiation to volumetrically heat a definable volume of blood that passes through said atrium, said radiation being absorbed by the blood and converted into heat; and

a temperature sensitive element disposed in said member downstream from said emitter for generating a signal corresponding to the temperature of the blood downstream from said emitter.

13. The catheter of claim 12 wherein said temperature sensitive element is disposed within the distal end of said catheter and wherein said emitter is disposed within a portion of said catheter at a position relative to said temperature sensitive element such that said emitter is located within said right atrium when said temperature sensitive element is located within the pulmonary artery.

14. The catheter of claim 17 wherein said electromagnetic radiation has a microwave frequency in the range of 1×

10⁸ to 3×

10¹¹ Hz.

15. The system of claim 12 wherein

said energy source generates electrical energy in the frequency range of 1 MHz to 100 MHz, and

said emitter comprises a transducer capable of converting said electrical energy to vibrational energy and acoustically radiating said vibrational energy within said volume of blood.

16. The system of claim 12 wherein said catheter further comprises a second temperature sensitive element disposed upstream from said emitter for generating a signal corresponding to the temperature of the blood upstream from said emitter.

17. The catheter of claim 12 wherein

said energy source generates electromagnetic radiation;

and

said emitter comprises an electromagnetic diffuser capable of distributing the electromagnetic radiation substantially uniformly across the length and around circumference of said diffuser.

18. The catheter of claim 17, wherein said electromagnetic radiation is ultraviolet light having a wavelength in a range of 1×

10^-8 to 4×

10^-7 meters.

19. The catheter of claim 17, where the electromagnetic radiation is visible light having a wavelength in the range of 4×

10^-7 to 7×

10^-7 meters.

20. The catheter of claim 17, wherein the electromagnetic radiation is infrared light having a wavelength in the range of 7×

10^-7 to 1×

10^-3 meters.

21. An apparatus for measuring fluid flow rate in a passageway, comprising:

an elongated member adapted to be inserted into flowing fluid;

an emitter, coupled to said elongated member, for emitting radiation to volumetrically heat a definable volume of flowing fluid, said radiation being absorbed by the flowing fluid and converted into heat;

a temperature sensitive element, located downstream from said emitting means, for generating a signal corresponding to the temperature of the flowing fluid downstream from said emitting means; and

control means for controlling the application of said radiation.

22. The apparatus of claim 21

including an energy source generating electrical energy in the frequency range of 1 MHz to 100 MHz, and

wherein said emitter comprises a transducer capable of converting said electrical energy to vibrational energy and acoustically radiating said vibrational energy within said volume of flowing fluid.

23. The system of claim 21 wherein said apparatus further comprises a second temperature sensitive element disposed upstream from said emitter for generating a signal corresponding to the temperature of the blood upstream from said emitter.

24. The apparatus of claim 21

including an energy source for generating electromagnetic radiation;

and

wherein said emitter comprises an electromagnetic diffuser capable of distributing the electromagnetic radiation substantially uniformly across the length and around circumference of said diffuser.

25. The apparatus of claim 24, wherein said electromagnetic radiation is ultraviolet light having a wavelength in a range of 1×

10^-8 to 4×

10^-7 meters.

26. The apparatus of claim 24, where the electromagnetic radiation is visible light having a wavelength in the range of 4×

10^-7 to 7×

10^-7 meters.

27. The apparatus of claim 24, wherein the electromagnetic radiation is infrared light having a wavelength in the range of 7×

10^-7 to 1×

10^-3.

28. The apparatus of claim 24 wherein said electromagnetic radiation has a microwave frequency in the range of 1×

10³ to 3×

10¹¹ Hz.

29. A method of measuring the volumetric flow rate of a fluid flowing from an upstream location towards a downstream location, comprising the steps of:

(1) inserting an elongated member into flowing fluid;

(2) sensing the baseline temperature of the flowing fluid;

(3) emitting, from an emitter coupled to said member, radiation to volumetrically heat a definable volume of flowing fluid, said radiation being absorbed by the flowing fluid and converted into heat;

(4) sensing the temperature of the flowing fluid downstream from said emitter;

(5) determining a volumetric flow rate of the flowing fluid in accordance with said temperatures and said emitted radiation.

30. The method of claim 29 wherein said baseline temperature of the flowing fluid is measured whenever said emitting radiation is zero.

31. The method of claim 29 wherein said baseline temperature of the flowing fluid is measured upstream from said emitter.

32. The method of claim 29 wherein said radiation is generated by a source of electromagnetic radiation having a wavelength in the ultraviolet light range of 1×

10^-8 to 4×

10^-7 meters and

wherein said emitter comprises an electromagnetic diffuser capable of distributing said electromagnetic radiation substantially uniformly across the length and around circumference of said diffuser.

33. The method of claim 29 wherein said radiation is generated by a source of electromagnetic radiation having a wavelength in the visible light range of 4×

10^-7 to 7×

10^-7 meters and

wherein said emitter comprises an electromagnetic diffuser capable of distributing said electromagnetic radiation substantially uniformly across the length and around circumference of said diffuser.

34. The method of claim 29 wherein said radiation is generated by a source of electromagnetic radiation having a wavelength in the infrared light range of 7×

10^-7 to 1×

10^-3 meters and

wherein said emitter comprises an electromagnetic diffuser capable of distributing said electromagnetic radiation substantially uniformly across the length and around circumference of said diffuser.

35. The method of claim 29 wherein said radiation is generated by a source of electromagnetic radiation having a microwave frequency in the range from 1×

10⁸ to 3×

10¹¹ Hz, and

wherein said emitter comprises a microwave antenna capable of distributing said microwave radiation substantially uniformly across the length and around circumference of said diffuser.

36. The method of claim 29 wherein said radiation is generated by a source of electrical energy in the frequency range of 1 MHz to 100 MHz, and

wherein said emitter comprises a transducer capable of converting said electrical energy to vibrational energy and acoustically radiating said vibrational energy within said volume of flowing fluid.

37. The method of claim 29, wherein said volumetric flow rate, in units of m³ /sec, is estimated by said central flow estimator using the relationship:

##EQU2## wherein q(t) is the applied heat (Watts), e_f is the density of the blood (Kg/m³),

c₁ is the specific heat of the blood (Joules/Kg °

K),

T(t) is the measured temperature at time t (°

K), and

T_Baseline is the baseline temperature (°

K).