Systems and methods for acquiring endocardially or epicardially paced electrocardiograms

• US 5,954,662 A
• Filed: 10/21/1997
• Issued: 09/21/1999
• Est. Priority Date: 02/17/1995
• Status: Expired due to Term

• Current Assignee: EP Technologies Incorporated (Boston Scientific Corporation)
• Original Assignee: EP Technologies Incorporated (Boston Scientific Corporation)
• Inventors: Panescu, Dorin, Swanson, David K., Whayne, James G.
• Primary Examiner(s): Jastrzab, Jeffrey R.
• Application Number:
  US08/955,328
• Time in Patent Office: 700 Days
• Field of Search: 600/509-511, 600/515, 600/518, 600/373-375, 607/9, 607/122, 364/724.01, 364/572, 364/574, 382/209
• US Class Current: 600/510
• CPC Class Codes: A61B 1/0051 with controlled bending of insertion part
• CPC Class Codes: A61B 18/1492 having a flexible, catheter-like structure, e.g. for heart ablation A61B18/1477 takes precedence
• CPC Class Codes: A61B 5/287 Holders for multiple electrodes, e.g. electrode catheters for electrophysiological study [EPS]
• CPC Class Codes: A61B 5/35 by template matching
• CPC Class Codes: A61B 5/6855 with a distal curved tip
• CPC Class Codes: A61B 5/6858 with a distal basket, e.g. expandable basket
• CPC Class Codes: A61N 1/056 Transvascular endocardial electrode systems
• CPC Class Codes: G16H 15/00 ICT specially adapted for medical reports, e.g. generation or transmission thereof
• CPC Class Codes: G16H 40/63 for local operation

Abstract

Systems and methods acquire electrocardiograms using a first electrode associated with a region of heart tissue and a second body surface electrode. An analog or digital processing element is coupled to the first and second electrodes for conditioning the first electrode to emit a pacing signal and for conditioning the second electrode to sense paced electrocardiograms occurring as a result of the pacing signal. The systems and methods also employ a template of an electrocardiogram of a cardiac event of known diagnosis; for example an arrhythmia that the physician seeks to treat. The systems and methods compare this event-specific template to a sample of a paced electrocardiogram. The comparison yields a matching coefficient indicating how alike the input sample is to the input template. The matching coefficient can be used by the physician, for example, to aid in the location of sites that are potentially appropriate for ablation.

Claims

1. A system for acquiring and analyzing electrograms in myocardial tissue comprising

a member supporting multiple electrodes in a three dimensional, radially expanded array adapted to be in operative association with a region of heart tissue,

a first processing element including a pacing module and a signal processing module coupled to the multiple electrodes to acquire a sample of a cardiac event by entrainment pacing the heart at a predetermined location while conditioning the multiple electrodes to sense paced electrograms occurring in the tissue region during entrainment pacing, and

a second processing element including means for electronically comparing the sample to a template of a cardiac event of known diagnosis and generating an output based upon the comparison, whereby the output provides a diagnostic indicator based upon entrainment pacing.

4. A system according to claim 1 or 2

wherein the output comprises a matching factor indicating how alike the sample is to the template.

5. A system according to claim 4

and further including a third processing element for comparing the matching factor to a predetermined value to identify a potential ablation site.

6. A system according to claim 1 or 2

wherein the second processing element compares the sample to the template by matched filtering.

7. A system according to claim 1 or 2

wherein the second processing element compares the sample to the template by cross correlation.

8. A system according to claim 1 or 2

wherein the second processing element compares the sample to the template by deriving a norm of the difference.

9. A system according to claim 1 or 2

wherein the second processing element compares the sample to the template by using the template to create a matched filtered sample having a symmetry and by analyzing the symmetry of the matched filtered sample.

10. A system according or claim 1 or 2

wherein the sample and the template each comprises a plot of biopotentials over time and not a spacial distribution of endocardial surface activation.

2. A system for acquiring and analyzing electrograms in myocardial tissue comprising

a member supporting multiple electrodes in a three dimensional, radially expanded array adapted to be in operative association with a region of heart tissue,

a first processing element including a pacing module and a signal processing module coupled to the multiple electrodes to acquire a sample of a cardiac event by conditioning at least one of the multiple electrodes to emit a pacing signal to entrainment pace myocardial tissue and to sense, using the multiple electrodes, paced electrograms occurring in the tissue region as a result of the pacing signal, and

a second processing element including means for electronically comparing the sample to a template of a cardiac event of known diagnosis and generating an output based upon the comparison, whereby the output provides a diagnostic indicator based upon entrainment pacing.

3. A system according to claim 2

wherein the first processing element sequentially conditions different ones of the multiple electrodes on the array to emit a pacing signal to entrainment pace myocardial tissue and to sense, using the multiple electrodes on the array, paced electrograms occurring as a result of entrainment pacing at different ones of the multiple electrodes.

11. A method for acquiring and analyzing electrograms in myocardial tissue comprising the steps of

deploying a three dimensional, radially expanded array of multiple electrodes in operative association with a region of heart tissue,

acquiring a sample of a cardiac event by entrainment pacing the heart at a predetermined location using the multiple electrodes, while conditioning the multiple electrodes to sense paced electrograms occurring in the tissue region during entrainment pacing, and

electronically comparing the sample to a template of a cardiac event of known diagnosis and generating an output based upon the comparison, whereby the output provides a diagnostic indicator based upon entrainment pacing.

12. A method according to claim 11

and further including the step of changing the predetermined location to entrainment pace the heart while conditioning the multiple electrodes to sense paced electrograms occurring as a result of entrainment pacing at different locations.

15. A method according to claim 11 or 13

wherein the comparing step provides an output comprising a matching factor indicating how alike the sample is to the template.

16. A method according to claim 15

and further including the step of comparing the matching factor to a predetermined value to identify a potential ablation site.

17. A method according to claim 11 or 13

wherein the comparing step electronically compares the sample to the template by matched filtering.

18. A method according to claim 11 or 13

wherein the comparing step electronically compares the sample to the template by cross correlation.

19. A method according to claim 11 or 13

wherein the comparing step electronically compares the sample to the template by deriving a norm of the difference.

20. A method according to claim 11 or 13

wherein the comparing step compares the sample to the template by using the template to create a matched filtered sample having a symmetry and by analyzing the symmetry of the matched filtered sample.

21. A method according to claim 11 or 13

wherein the sample and the template each comprise a plot of biopotentials over time and not a spacial distribution of endocardial surface activation.

13. A method for acquiring and analyzing electrograms in myocardial tissue comprising the steps of

deploying a three dimensional, radially expanded array of multiple electrodes in operative association with a region of heart tissue,

acquiring a sample of a cardiac event by conditioning at least one of the multiple electrodes to emit a pacing signal to entrainment pace myocardial tissue and to sense, using the multiple electrodes, paced electrograms occurring in the tissue region as a result of the pacing signal, and

electronically comparing the sample to a template of a cardiac event of known diagnosis and generating an output based upon the comparison, whereby the output provides a diagnostic indicator based upon entrainment pacing.

14. A method according to claim 13

and further including the steps of sequentially conditioning different ones of the multiple electrodes on the array to emit a pacing signal to entrainment pace myocardial tissue while sensing using multiple electrodes on the array paced electrograms occurring as a result of entrainment pacing at different ones of the multiple electrodes.