Cardiac ablation catheter using correlation measure

• US 5,954,665 A
• Filed: 10/23/1997
• Issued: 09/21/1999
• Est. Priority Date: 06/07/1995
• Status: Expired due to Term

• Current Assignee: Biosense, Inc. (Cardinal Health, Inc.)
• Original Assignee: Biosense, Inc. (Cardinal Health, Inc.)
• Inventors: Ben-Haim, Shlomo
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): LAYNO, CARL HERNANDZ
• Application Number:
  US08/956,687
• Time in Patent Office: 698 Days
• Field of Search: 607/6, 607/122, 607/125, 607/101, 600/515, 600/518
• US Class Current: 600/515
• CPC Class Codes: A61B 18/04 by heating by applying electromagnetic radiation A61B18/18; hyperthermia using electric or magnetic fields, radiation or ultrasound A61N
• CPC Class Codes: A61B 18/1492 having a flexible, catheter-like structure, e.g. for heart ablation A61B18/1477 takes precedence
• CPC Class Codes: A61B 2018/00041 Heating, e.g. defrosting
• CPC Class Codes: A61B 2034/2051 Electromagnetic tracking systems
• CPC Class Codes: A61B 5/06 Devices, other than using radiation, for detecting or locating foreign bodies for removing same A61B17/50 ; determining position of probes within or on the body of the patient
• CPC Class Codes: A61B 5/062 using magnetic field
• CPC Class Codes: A61N 1/056 Transvascular endocardial electrode systems
• CPC Class Codes: A61N 1/06 for high-frequency therapy
• CPC Class Codes: A61N 1/403 for thermotherapy, e.g. hyperthermia

Abstract

Apparatus for endocardiac therapy, including an elongate probe for insertion into the heart of a subject, the probe having distal and proximal ends. The probe includes an ablation device near the distal end of the probe for ablating heart tissue and at least two sensing electrodes, for sensing activation signals in the heart tissue adjacent to the ablation device. Signal analyzer circuitry receives and correlates the activation signals. Preferably, the probe includes a position sensor adjacent to the ablation device, which generates signals responsive to the position of the probe with respect to an external frame of reference.

Claims

1. A method for assessing the effectiveness of treatment of abnormal conduction paths in the heart of a subject, comprising:

positioning a probe at a treatment site in the heart;

sensing respective first and second electrical signals, using the probe, at first and second points in the endocardium in a vicinity of the site; and

determining a correlation measure of the first and second signals sensed by the probe, so as to detect an abnormal conduction path in the vicinity of the site.

2. A method according to claim 1, wherein determining the correlation measure comprises performing a time-domain correlation computation.

3. A method according to claim 1, wherein determining the correlation measure comprises computing a phase shift to give a correlation value.

4. A method according to claim 1, wherein determining the correlation measure comprises computing frequency spectra of the first and second signals.

5. A method according to claim 1, wherein sensing the electrical signals comprises receiving bipolar electrogram signals.

6. A method according to any of the preceding claims, and comprising interrupting conduction at the site using the probe.

7. A method according to claim 6, wherein sensing the electrical signals comprises sensing respective first and second signals before interrupting the conduction.

8. A method according to claim 6, wherein sensing the electrical signals comprises sensing respective first and second signals after interrupting the conduction.

9. A method according to claim 6, wherein sensing the electrical signals comprises sensing respective first and second pre-interruption signals before interrupting the conduction and sensing respective first and second post-interruption signals after interrupting the conduction, and comprising comparing the correlation measure of the first and second pre-interruption signals with that of the first and second post-interruption signals.

10. A method according to claim 9, wherein comparing the correlation measure comprises:

finding a first correlation measure using the first and second pre-interruption signals;

finding a second correlation measure using the first and second post-interruption signals; and

calculating a difference of the first and second correlation measures to determine effectiveness of the treatment.

11. A method according to claim 6, wherein interrupting conduction comprises transferring energy between the probe and the site.

12. A method according to claim 11, wherein transferring energy between the probe and the site comprises ablating the site.

13. A method according to claim 12, wherein ablating the site comprises ablating a generally linear area in the vicinity of the site.

14. A method according to claim 12, wherein ablating the site comprises ablating an area having a complex shape in the vicinity of the site.

15. A method according to claim 11, wherein transferring energy between the probe and the site comprises cooling the site.

16. A method according to claim 15, and comprising determining the effect of cooling the site on the correlation of the signals and ablating the site responsive to the effect.

17. A method for mapping electrical activity in the heart of a subject, comprising:

positioning a probe at a plurality of sites in the heart;

sensing respective first and second electrical signals, using the probe, at first and second points in the endocardium in the respective vicinity of each of the plurality of sites;

processing the signals sensed by the probe to determine a correlation measure of the respective first and second signals at each of the plurality of sites; and

producing a map of the correlation measures.

18. A method according to claim 17, wherein producing the map comprises producing a map showing the location of an abnormal conduction path.

19. A method according to claim 17, and comprising the additional steps of:

ablating a lesion at a site in the heart;

positioning the probe in a vicinity of the lesion ablated in the tissue, after producing the map;

receiving electrical signals, using the probe, from at least two points in the vicinity of the lesion after ablation thereof;

processing the signals received by the probe to determine the correlation measure between the signals at the points in the vicinity of the lesion after the ablation; and

comparing the measure determined after the ablation to the measure determined before the ablation to determine the effectiveness of treatment.

23. A method according to any of claims 17-22, wherein receiving electrogram signals comprises receiving bipolar electrogram signals.

24. A method according to any of claims 17-22, wherein processing the signals to determine the correlation measure comprises performing a time-domain correlation computation.

25. A method according to any of claims 17-22, wherein processing the signals to determine the correlation measure comprises computing a phase shift to give a correlation value.

26. A method according to any of claims 17-22, wherein processing the signals comprises computing frequency spectra of the signals.

20. A method for determining the effect of ablation on excitable tissue, comprising:

positioning a probe in a vicinity of a lesion ablated in the tissue;

receiving electrical signals, using the probe, from at least two points in the vicinity; and

processing the signals received by the probe to determine a correlation measure between the signals at the points.

21. A method according to claim 20, and comprising comparing the correlation measure with a previous correlation measure determined by processing signals received from at least two of the at least two points before ablating the tissue.

22. A method according to claim 20, wherein receiving signals from the at least two points comprises receiving signals from a plurality of pairs of points, and wherein processing the signals comprises producing a correlation map of the tissue, indicative of the effect of the ablation.

27. Intracardiac apparatus, comprising:

an elongate probe for insertion into the heart of a subject, said probe having distal and proximal ends and comprising at least two sensing electrodes near the distal end of the probe, for sensing signals in the heart tissue; and

signal analyzer circuitry, which receives the signals from the probe and calculates a correlation measure of the signals.

28. Apparatus according to claim 27, wherein the sensing electrodes comprise bipolar electrodes.

29. Apparatus according to claim 27, wherein the probe comprises a position sensor, which generates signals responsive to the position of the probe with respect to an external frame of reference.

30. Apparatus according to claim 27, wherein the probe is positioned at a plurality of locations in the heart, and the signal analyzer circuitry produces a map of the correlation measures determined at the plurality of locations.

31. Apparatus according to any of claims 27-30, wherein the probe comprises a tissue ablation device adjacent the distal end of the probe.

32. Apparatus according to claim 31, wherein the ablation device comprises an ablation electrode, and wherein one of the at least two sensing electrodes is also an ablation electrode.

33. Apparatus according to claim 31, wherein the ablation device is disposed over and substantially covers the outer surface of the distal end of the probe.

34. Apparatus according to claim 31, wherein the ablation device and electrodes have positions along an outer, radial surface of the probe, wherein one electrode is axially proximal to the ablation device, and the other electrode is axially distal to the ablation device.

35. Apparatus according to claim 31, and comprising a cooler, for cooling the heart tissue, adjacent to the ablation device.

36. Apparatus according to claim 31, and comprising a cooler thermally coupled to the ablation device, which cools the heart tissue.

37. Apparatus for determining the effectiveness of treatment of abnormal conduction in the heart of a subject, comprising:

an elongate probe for insertion into the heart of the heart, said probe having distal and proximal ends and comprising at least two sensing electrodes near the distal end of the probe, for sensing activation signals in the heart tissue; and

signal analyzer circuitry, which receives the activation signals from the probe, determines a correlation measure thereof, and compares a first correlation measure determined before the treatment with a second correlation measure determined after the treatment.

38. Apparatus according to claim 37, wherein the sensing electrodes comprise bipolar electrodes.

39. Apparatus according to claim 37, wherein the probe comprises a position sensor near the distal end thereof, which generates signals responsive to the position of the probe with respect to an external frame of reference.

40. Apparatus according to claim 37, wherein the probe is positioned at a plurality of locations in the heart, and the signal analyzer circuitry produces a map of the correlation measures determined at the plurality of locations.