Jet injector

• US 5,954,689 A
• Filed: 12/09/1997
• Issued: 09/21/1999
• Est. Priority Date: 12/20/1996
• Status: Expired due to Fees

• Current Assignee: Novo Nordisk A/S
• Original Assignee: Novo Nordisk A/S
• Inventors: Poulsen, Jens Ulrik
• Primary Examiner(s): Coggins, Wynn Wood
• Assistant Examiner(s): KENNEDY, SHARON E
• Application Number:
  US08/987,716
• Time in Patent Office: 651 Days
• Field of Search: 604/68, 604/71, 604/72, 604/186, 604/201, 604/207, 604/208, 604/211, 604/232
• US Class Current: 604/71
• CPC Class Codes: A61M 5/2046 Media being expelled from injector by gas generation, e.g. explosive charge
• CPC Class Codes: A61M 5/24 Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic ampoules or carpules A61J1/06
• CPC Class Codes: A61M 5/30 Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
• CPC Class Codes: A61M 5/31525 Dosing burettes, pipettes B01L3/02
• CPC Class Codes: A61M 5/31551 including axial movement of dose setting member
• CPC Class Codes: A61M 5/31591 Single dose, i.e. individually set dose administered only once from the same medicament reservoir, e.g. including single stroke limiting means

Abstract

An injector comprising a changeable cylinder ampoule (2) containing medicine for a number of injections into which ampoule a piston (4) is pressed by a piston rod (9) driven by a drive mechanism to dispense a dose of medicine through a nozzle (5) as a high speed jet which penetrates the skin. The injector comprises a distal part (1) accommodating the cylinder ampoule (2) and a proximal part (8) containing the drive mechanism and the piston rod (9) which can be advanced a set distance by the drive mechanism when released, the distal and the proximal parts being provided with mutually engaging threads so that one of these parts can successively be screwed into the other to set a dose to be delivered by the device.

Claims

1. An injector comprising a proximal part and a distal part which parts are provided with co-operating threads so that one part can be screwed into the other part,

wherein the distal part accommodates a changeable cylinder ampoule containing medicine, stored between a piston and a closure membrane, for a plurality of injections and a nozzle which communicates, through the closure membrane, with the stored medicine such that medicine is expelled through the nozzle when the piston is pressed into the ampoule, and

wherein the proximal part comprises a piston rod and a spring so arranged that the spring can be cocked and released to move the piston rod in a distal direction towards the piston of the ampoule to move the piston into the ampoule to dispense a dose of medicine through the nozzle as a high speed, skin penetrating jet, and a dose setting mechanism by which the distance which the piston rod moves the piston into the cylinder ampoule, when the spring is released, can be set in advance of each release of the spring by screwing one of the distal and the proximal parts a corresponding distance into the other part.

2. An injector according to claim 1, wherein the piston rod is axially moveable, relative to the proximal part, a fixed distance between a release position and a cocked position, wherein the spring is cocked in conjunction with moving the piston rod from the release position to the cocked position, wherein the proximal part and piston rod include cooperating catch members for temporarily holding the piston rod, upon reaching the cocked position, against movement in the distal direction, wherein the proximal part and piston rod include mutually engageable members for stopping the distal movement of the piston rod when the piston rod reaches the release position, and wherein the proximal part includes a release button for releasing the catch members to allow the piston to move in a distal direction towards the release position, whereby the piston rod, when moved from the release position to the cocked position, moves away from the ampoule piston by the said fixed distance, whereby one of the parts may thereafter be screwed into the other part to move the ampoule piston towards the piston rod by a desired distance and thereby set the size of the dose to be administered, and whereby the release button may thereafter be actuated to allow the piston rod to move in a distal direction to the release position and, in so doing, expel the set dose through the nozzle.

3. A method of administering a dose of medicine using an injector having a proximal part and a distal part, which parts include cooperating threads so that one part can be screwed into the other part, wherein the distal part can accommodate an ampoule and the proximal part contains a piston rod having proximal and distal ends, and wherein the piston rod is axially moveable relative to the proximal part;

said method comprising the steps of;

(a) inserting an ampoule, containing medicine between a piston and a closure membrane, into the distal part;

(b) moving the piston rod to a release position;

(c) screwing the proximal and distal parts towards one another such that, with the piston rod in the release position, the proximal end of the piston rod abuts the ampoule piston;

(d) providing a nozzle which communicates with the medicine through the closure membrane for expelling a dose;

(e) moving the piston rod in a proximal direction from the release position to a cocked position such that the distal end of the piston rod moves a fixed distance away from the ampoule piston, and such that a spring is cocked to urge the piston rod to move in the distal direction; and

, after performing steps (a) through (e),

(f) screwing one part into the other part so as to move the ampoule piston a desired distance towards the piston rod to set a desired dose; and

, thereafter,

(g) releasing the piston rod such that the spring moves the piston rod in a distal direction by the said fixed distance to expel the set dose as a high speed, skin penetrating jet.

4. A method according to claim 3, comprising the steps of temporarily latching the piston rod, upon reaching the cocked position, relative to the proximal part, to hold the piston rod against movement in the distal direction while setting the dose, and thereafter releasing the piston rod when the dose administration is desired.