Electrophoresis apparatus and method involving parallel channels
First Claim
Patent Images
1. An electrophoresis apparatus comprising:
- a substrate;
a first filling region supported by the substrate;
a first plurality of electrophoresis lanes supported by the substrate, the first plurality of electrophoresis lanes in communication with the first filling region;
a second filling region supported by the substrate; and
a second plurality of electrophoresis lanes supported by the substrate, the second plurality of electrophoresis lanes in communication with the second filling region;
wherein the first plurality of electrophoresis lanes is adjacent the second plurality of electrophoresis lanes; and
wherein a distance between the first plurality of electrophoresis lanes and the second plurality of electrophoresis lanes is greater than a distance between each adjacent pair of the first plurality of electrophoresis lanes.
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Abstract
An electrophoresis apparatus includes a substrate (34) which supports a filling region (22) and a plurality of electrophoresis lanes (20). The filling region (22) communicates a sample to the plurality of electrophoresis lanes (20). A method of electrophoresis includes providing the above-described electrophoresis apparatus, applying a sample to the filling region (22), the plurality of electrophoresis lanes (20) receiving the sample from the filling region (22), and electrophoresing the sample in the plurality of electrophoresis lanes (20).
44 Citations
21 Claims
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1. An electrophoresis apparatus comprising:
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a substrate; a first filling region supported by the substrate; a first plurality of electrophoresis lanes supported by the substrate, the first plurality of electrophoresis lanes in communication with the first filling region; a second filling region supported by the substrate; and a second plurality of electrophoresis lanes supported by the substrate, the second plurality of electrophoresis lanes in communication with the second filling region; wherein the first plurality of electrophoresis lanes is adjacent the second plurality of electrophoresis lanes; and wherein a distance between the first plurality of electrophoresis lanes and the second plurality of electrophoresis lanes is greater than a distance between each adjacent pair of the first plurality of electrophoresis lanes. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. An electrophoresis apparatus comprising:
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a substrate; a plurality of electrophoresis lanes supported by the substrate; a filling region supported by the substrate, the filling region having a sample-receiving opening at a first end and openings to the plurality of electrophoresis lanes at a second end; wherein a dimension of the filling region is greater at the sample-receiving opening than at the openings to the plurality of electrophoresis lanes; and wherein an axis defined from the first end to the second end of the filling region is substantially parallel to the plurality of electrophoresis lanes.
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19. An electrophoresis apparatus comprising:
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a substrate; a first filling region defined by the substrate, the first filling region having a first sample-receiving opening at a first sample-receiving end and a first plurality of openings at a first channel-opening end; a first plurality of electrophoresis channels defined by the substrate, the first plurality of electrophoresis channels in communication with the first plurality of openings of the first filling region, the first plurality of electrophoresis channels substantially parallel to a first axis from the first sample-receiving end to the first channel-opening end of the first filling region; a first plurality of molecular sensors including a respective molecular sensor for each of the first plurality of electrophoresis channels; a second filling region defined by the substrate, the second filling region having a second sample-receiving opening at a second sample-receiving end and a second plurality of openings at a second channel-opening end; a second plurality of electrophoresis channels defined by the substrate, the second plurality of electrophoresis channels in communication with the second plurality of openings of the second filling region, the second plurality of electrophoresis channels substantially parallel to a second axis from the second sample-receiving end to the second channel-opening end of the first filling region; wherein the first plurality of electrophoresis channels is adjacent to the second plurality of electrophoresis channels, and a distance between the first plurality of electrophoresis channels and the second plurality of electrophoresis channels is greater than a distance between adjacent pairs of the first plurality of electrophoresis channels; and a second plurality of molecular sensors including a respective molecular sensor for each of the second plurality of electrophoresis channels.
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20. A method of electrophoresis, the method comprising the steps of:
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providing an electrophoresis device having a first filling region, a second filling region adjacent the first filling region, a first plurality of electrophoresis lanes in communication with the first filling region, and a second plurality of electrophoresis lanes in communication with the second filling region and adjacent the first plurality of electrophoresis lanes, wherein a distance between the first plurality of electrophoresis lanes and the second plurality of electrophoresis lanes is greater than a distance between each adjacent pair of the first plurality of electrophoresis lanes and each adjacent pair of the second plurality of electrophoresis lanes; applying a first sample to the first filling region, the first plurality of electrophoresis lanes receiving the first sample from the first filling region; applying a second sample to the second filling region, the second plurality of electrophoresis lanes receiving the second sample from the second filling region; electrophoresing the first sample in the first plurality of electrophoresis lanes; and electrophoresing the second sample in the second plurality of electrophoresis lanes.
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21. A method of electrophoresis, the method comprising the steps of:
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providing an electrophoresis device having a filling region and a plurality of electrophoresis lanes in communication with the filling region, the filling region having a sample-receiving opening at a first end and openings to the plurality of electrophoresis lanes at a second end, wherein a dimension of the filling region is greater at the sample-receiving opening than at the openings to the plurality of electrophoresis lanes, and wherein an axis defined from the first end to the second end of the filling region is substantially parallel to the plurality of electrophoresis lanes; applying a sample to the filling region, the plurality of electrophoresis lanes receiving the sample from the filling region; and electrophoresing the sample in the plurality of electrophoresis lanes.
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Specification