Pumped-filter blood-processing apparatus and methods
First Claim
1. Apparatus for processing at least two blood components, the apparatus comprising:
- a. a source of at least two blood components;
b. collection means comprising first and second separate containers for collecting first and second blood components;
c. a controllable pump for drawing the at least one blood component from the source to the collection means;
d. a filter for filtering at least one blood component prior to collection;
e. means for measuring pressure into the filter;
f. feedback means for controlling the pump based on the measured pressure and the blood component being directed through the filter;
g. means for separately directing the first blood component through the filter and into the first container; and
h. means for separately directing the second blood component through the filter and into the second container.
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Abstract
Automated filtration of whole blood or blood components is accomplished in a manner that ensures consistent flow or pressure characteristics through the filter. A feedback circuit monitors pressure in the vicinity of the filter inlet and controls operation of a fluid pump that sends one or more unfiltered blood components into the filter. Using this arrangement, a variety of parameters relating to filtration efficacy can be precisely controlled, including flow rate, flow pressure, and average pressure over a predetermined volume. The system may provide an alarm or automatic cut-off in the event a maximum value of one of the parameters is reached or exceeded. The system is also capable of serially filtering multiple blood products through the single filter and accommodating different flow or pressure characteristics associated with each such product.
143 Citations
31 Claims
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1. Apparatus for processing at least two blood components, the apparatus comprising:
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a. a source of at least two blood components; b. collection means comprising first and second separate containers for collecting first and second blood components; c. a controllable pump for drawing the at least one blood component from the source to the collection means; d. a filter for filtering at least one blood component prior to collection; e. means for measuring pressure into the filter; f. feedback means for controlling the pump based on the measured pressure and the blood component being directed through the filter; g. means for separately directing the first blood component through the filter and into the first container; and h. means for separately directing the second blood component through the filter and into the second container. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 11, 12, 13, 14, 15, 16)
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10. Apparatus for processing at least two blood components, the apparatus comprising:
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a. a source of at least two blood components; b. collection means for collecting the at least one blood component; c. means for separating the blood components; d. a controllable pump for directing the blood components to the collection means; e. a filter for filtering at least one blood component prior to collection, the filter having an internal volume, at least one separated component following a flow path from the separating means through the filter and into the collection means; f. means for measuring pressure into the filter; g. feedback means for controlling the pump based on the measured pressure; h. means for containing a liquid; and i. means for selectably coupling to the flow path and flowing the liquid therethrough to substantially displace the at least one blood component from the internal volume of the filter.
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17. A method of processing at least two blood components, the method comprising the steps of:
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a. providing a source of the at least two blood components and a filter; b. flowing at least one blood component from the source to the filter; c. filtering each of the at least two blood components separately and, during said filtration, measuring pressure into the filter; d. controlling the flow based on the measured pressure and the blood component being filtered; and e. separately collecting each of the at least two blood components. - View Dependent Claims (18, 19, 20, 21, 22, 23, 24, 25, 27, 28, 29, 30, 31)
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26. A method of processing at least one blood component, the method comprising the steps of:
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a. providing a source of the at least one blood component and a filter therefor, the filter having an internal volume; b. flowing the at least one blood component from the source to the filter; c. filtering at least one blood component and, during said filtration, measuring pressure into the filter; d. controlling the flow based on the measured pressure; and e. pumping a liquid through the filter to substantially displace the at least one blood component from the internal volume of the filter.
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Specification