Microporous macrocapsules
First Claim
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1. An implantable permselective device for use in cell therapy comprising:
- (a) a core comprising living cells that are capable of secreting a selected biologically active product or of providing a selected biological function; and
(b) an external jacket surrounding said core, said jacket comprising a biocompatible material substantially free of said cells, said jacket having a nominal molecular weight cutoff greater than about 440 kD;
said core and said jacket forming a macrocapsule, which device is substantially non-immunoisolatory.
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Abstract
Microporous macrocapsules are disclosed which are useful as implantation devices for cell therapy. The macrocapsule comprises living cells that secrete biological substance that are therapeutically useful and that are released from the macrocapsule to the site of implantation. The capsules can have selected permeability characteristics based upon their particular usage and desired viral retentivity characteristics.
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Citations
19 Claims
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1. An implantable permselective device for use in cell therapy comprising:
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(a) a core comprising living cells that are capable of secreting a selected biologically active product or of providing a selected biological function; and (b) an external jacket surrounding said core, said jacket comprising a biocompatible material substantially free of said cells, said jacket having a nominal molecular weight cutoff greater than about 440 kD;
said core and said jacket forming a macrocapsule, which device is substantially non-immunoisolatory. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. An implantable device for providing a therapeutically useful product to a recipient, the device comprising:
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(a) a core comprising a polymeric implant that is capable of secreting a selected therapeutically useful product, and (b) an external jacket surrounding said core formed of a biocompatible material, said jacket having a nominal molecular weight cutoff greater than about 440 kD; said core and said jacket forming a macrocapsule, which macrocapsule is substantially non-immunoisolatory.
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15. A method of cell therapy comprising implanting a permselective device into the body of a recipient, said device comprising:
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(a) a core comprising living cells that are capable of secreting a selected biologically active product or of providing a selected biological function; and (b) an external jacket surrounding said core, said jacket comprising a biocompatible material substantially free of said cells, said jacket having a nominal molecular weight cutoff greater than about 440 kD; said core and said jacket forming a macrocapsule, which macrocapsule is substantially non-immunoisolatory. - View Dependent Claims (16, 17, 18, 19)
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Specification