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Multilayered submucosal graft constructs and method for making the same

  • US 5,955,110 A
  • Filed: 11/12/1996
  • Issued: 09/21/1999
  • Est. Priority Date: 04/07/1995
  • Status: Expired due to Term
First Claim
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1. A method of preparing a multi-laminate tissue graft construct having pseudoisotropic properties, said construct formed from at least three strips of intestinal submucosal tissue delaminated from both the tunica muscularis and at least the luminal portion of the tunica mucosa of a wanm blooded vertebrate, each strip of intestinal submucosal tissue having a longitudinal axis corresponding to the predominant orientation of the collagen fibers in the submucosal tissue strips, said method comprising the steps ofoverlaying said first strip with at least two additional strips of submucosal tissue so that the longitudinal axis of each individual strip of submucosal tissue forms an angle of about 180°

  • /N with the longitudinal axes of two other strips of overlaid submucosal tissue, wherein N=the total number of strips of submucosal tissue;

    compressing at least the overlapped portions of the strips of submucosal tissue between two surfaces under conditions allowing at least partial dehydration of the compressed submucosal tissue.

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