Method of determining a glucose concentration in a target by using near-infrared spectroscopy
First Claim
1. A method of determining a glucose concentration in a target by using near-infrared spectroscopy, said method comprising the steps of:
- projecting near-infrared radiation on said target;
receiving resulting radiation emitted from said target;
performing spectrum analysis of the resulting radiation to detect at least one first absorption signal from a first wavelength region having an absorption peak of OH group derived from glucose molecule, at least one second absorption signal from a second wavelength region having an absorption peak of NH group in said target, and at least one third absorption signal from a third wavelength region having an absorption peak of CH group in said target; and
determining said glucose concentration by multivariate analysis of results of said spectrum analysis, in which said first, second and third absorption signals are used as explanatory variables, and said glucose concentration is a criterion variable,wherein said first absorption signal is an absorbency at a first wavelength in said first wavelength region, said second absorption signal is an absorbency at a second wavelength in said second wavelength region, and said third absorption signal is an absorbency at a third wavelength in said third wavelength region, and wherein said first, second and third wavelengths are determined by a method comprising the steps of;
measuring a plurality of absorption spectrums in at least one sample;
performing multivariate analysis of said absorption spectrums to obtain a profile indicative of a relation between wavelength and regression coefficient; and
selecting as said first wavelength a wavelength substantially corresponding to a peak of said regression coefficient within said first wavelength region, selecting as said second wavelength a wavelength substantially corresponding to a peak of said regression coefficient within said second wavelength region, and selecting as said third wavelength a wavelength substantially corresponding to a peak of said regression coefficient within said third wavelength region.
8 Assignments
0 Petitions
Accused Products
Abstract
A glucose concentration in a living tissue as a target is determined by the following method. Near-infrared radiation is projected on the living tissue, and a resulting radiation emitted from the living tissue is received. A spectrum analysis of the resulting radiation is performed to detect a first absorption signal from a wavelength region, e.g., 1550 nm to 1650 nm, having an absorption peak of OH group derived from glucose molecule, a second absorption signal from a wavelength region, e.g., 1480 nm to 1550 nm, having an absorption peak of NH group in the living tissue, and a third absorption signal from a wavelength region, e.g., 1650 nm to 1880 nm, having an absorption peak of CH group in the living tissue. The glucose concentration is determined by a multivariate analysis of results of the spectrum analysis, in which the first, second and third absorption signals are used as explanatory variables, and the glucose concentration is a criterion variable. This method can predict the glucose concentration of the subject with an improved accuracy.
117 Citations
12 Claims
-
1. A method of determining a glucose concentration in a target by using near-infrared spectroscopy, said method comprising the steps of:
-
projecting near-infrared radiation on said target; receiving resulting radiation emitted from said target; performing spectrum analysis of the resulting radiation to detect at least one first absorption signal from a first wavelength region having an absorption peak of OH group derived from glucose molecule, at least one second absorption signal from a second wavelength region having an absorption peak of NH group in said target, and at least one third absorption signal from a third wavelength region having an absorption peak of CH group in said target; and determining said glucose concentration by multivariate analysis of results of said spectrum analysis, in which said first, second and third absorption signals are used as explanatory variables, and said glucose concentration is a criterion variable, wherein said first absorption signal is an absorbency at a first wavelength in said first wavelength region, said second absorption signal is an absorbency at a second wavelength in said second wavelength region, and said third absorption signal is an absorbency at a third wavelength in said third wavelength region, and wherein said first, second and third wavelengths are determined by a method comprising the steps of; measuring a plurality of absorption spectrums in at least one sample; performing multivariate analysis of said absorption spectrums to obtain a profile indicative of a relation between wavelength and regression coefficient; and selecting as said first wavelength a wavelength substantially corresponding to a peak of said regression coefficient within said first wavelength region, selecting as said second wavelength a wavelength substantially corresponding to a peak of said regression coefficient within said second wavelength region, and selecting as said third wavelength a wavelength substantially corresponding to a peak of said regression coefficient within said third wavelength region. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
-
-
12. A method of determining a glucose concentration in a target by using near-infrared spectroscopy, said method comprising the steps of:
-
projecting near-infrared radiation on said target; receiving resulting radiation emitted from said target; performing spectrum analysis of the resulting radiation to detect at least one first absorption signal from a first wavelength region having an absorption peak of OH group derived from glucose molecule, at least one second absorption signal from a second wavelength region having an absorption peak of NH group in said target, and at least one third absorption signal from a third wavelength region having an absorption peak of CH group in said target; and determining said glucose concentration by multivariate analysis of results of said spectrum analysis, in which said first, second and third absorption signals are used as explanatory variables, and said glucose concentration is a criterion variable, wherein said first wavelength region is in a range of 1600±
40 nm, said second wavelength region is in a range of 1530±
20 nm, and said third wavelength region is in a range selected from the group consisting of 1685±
20 nm, 1715±
20 nm, and 1740±
20 nm.
-
Specification