Tetravalent bispecific receptors, the preparation and use thereof
First Claim
1. A bispecific, tetravalent antibody of FIG. 25 or FIG. 26 wherein H L represents an amino acid sequence comprising one or more hinge regions (H) and a linker peptide (L), thick lines represent peptide bonds, thin lines represent disulfide bridges connecting the two polypeptide chains of said antibody, and wherein the VL1 and VH1 domains of FIGS. 25 and 26 correspond to such domains of a first antibody and are paired naturally, the VL2 and VH2 domains of FIGS. 25 and 26 correspond to such domains of a second, different antibody and are paired naturally, and wherein the CH1 domains are bound to the VH2 domains by 1 to 10 hinge regions H and a suitable linker peptide L.
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Abstract
The invention relates to bispecific tetravalent receptors of the formula I ##STR1## or formula II ##STR2## against a tumor-associated antigen and against an agent active against tumors.
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Citations
9 Claims
- 1. A bispecific, tetravalent antibody of FIG. 25 or FIG. 26 wherein H L represents an amino acid sequence comprising one or more hinge regions (H) and a linker peptide (L), thick lines represent peptide bonds, thin lines represent disulfide bridges connecting the two polypeptide chains of said antibody, and wherein the VL1 and VH1 domains of FIGS. 25 and 26 correspond to such domains of a first antibody and are paired naturally, the VL2 and VH2 domains of FIGS. 25 and 26 correspond to such domains of a second, different antibody and are paired naturally, and wherein the CH1 domains are bound to the VH2 domains by 1 to 10 hinge regions H and a suitable linker peptide L.
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9. A bispecific, tetravalent antibody of FIG. 25 wherein H L represents an amino acid sequence comprising one or more hinge regions (H) and a linker peptide (L), thick lines represent peptide bonds, thin lines represent disulfide bridges connecting the two polypeptide chains of said antibody, in which the CH3 domains are replaced by human CH1 domains.
Specification