Glucose concentration measuring method and apparatus
First Claim
1. A glucose concentration measuring method, comprising the steps of:
- i) irradiating an ultrashort pulsed light beam, which has been radiated out of a predetermined light source, to the eyeball,ii) measuring each of an intensity of a first backward scattered light beam of said ultrashort pulsed light beam, said first backward scattered light beam coming from an interface between the cornea and the anterior aqueous chamber of the eyeball, and an intensity of a second backward scattered light beam of said ultrashort pulsed light beam, said second backward scattered light beam coming from an interface between the anterior aqueous chamber and the crystalline lens of the eyeball,iii) obtaining light absorption characteristics of constituents of the aqueous humor, which fills the anterior aqueous chamber, from the intensity of said first backward scattered light beam and the intensity of said second backward scattered light beam,iv) obtaining light absorption characteristics of the constituents of the aqueous humor with respect to each of a plurality of other ultrashort pulsed light beams, which have wavelengths different from the wavelength of said ultrashort pulsed light beam, by repeating steps i)-iii) with each of the plurality of other ultrashort pulsed light beams, andv) calculating a concentration of glucose in the constituents of the aqueous humor from the light absorption characteristics, which have been obtained with respect to the plurality of said ultrashort pulsed light beams having different wavelengths.
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Abstract
A low coherence light beam is irradiated to the eyeball. A backward scattered light beam, which is reflected from each depth position in the eyeball, and a reference light beam, which is reflected from a mirror capable of moving, are caused to interfere with each other. A first backward scattered light beam, which comes from the interface between the cornea and the anterior aqueous chamber, and a second backward scattered light beam, which comes from the interface between the anterior aqueous chamber and the crystalline lens, are thus separated accurately from each other. An optical absorbance of the anterior aqueous chamber (the aqueous humor) is calculated from the intensities of the two backward scattered light beams. Each of a plurality of low coherence light beams having different wavelengths is irradiated to the eyeball, and the aforesaid operation is repeated. The concentration of glucose in the aqueous humor is measured by utilizing near-infrared spectroscopy. The measurement is thus achieved non-invasively and accurately.
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Citations
8 Claims
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1. A glucose concentration measuring method, comprising the steps of:
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i) irradiating an ultrashort pulsed light beam, which has been radiated out of a predetermined light source, to the eyeball, ii) measuring each of an intensity of a first backward scattered light beam of said ultrashort pulsed light beam, said first backward scattered light beam coming from an interface between the cornea and the anterior aqueous chamber of the eyeball, and an intensity of a second backward scattered light beam of said ultrashort pulsed light beam, said second backward scattered light beam coming from an interface between the anterior aqueous chamber and the crystalline lens of the eyeball, iii) obtaining light absorption characteristics of constituents of the aqueous humor, which fills the anterior aqueous chamber, from the intensity of said first backward scattered light beam and the intensity of said second backward scattered light beam, iv) obtaining light absorption characteristics of the constituents of the aqueous humor with respect to each of a plurality of other ultrashort pulsed light beams, which have wavelengths different from the wavelength of said ultrashort pulsed light beam, by repeating steps i)-iii) with each of the plurality of other ultrashort pulsed light beams, and v) calculating a concentration of glucose in the constituents of the aqueous humor from the light absorption characteristics, which have been obtained with respect to the plurality of said ultrashort pulsed light beams having different wavelengths. - View Dependent Claims (2, 3, 4)
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5. A glucose concentration measuring apparatus, comprising:
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i) a light source device for radiating out a plurality of ultrashort pulsed light beams, which have different wavelengths, ii) an optical time-domain backward scattering measurement means for irradiating said plurality of ultrashort pulsed light beams to the eyeball, and carrying out time series measurement of each of an intensity of a first backward scattered light beam of said ultrashort pulsed light beam, said first backward scattered light beam coming from an interface between the cornea and the anterior aqueous chamber of the eyeball, and an intensity of a second backward scattered light beam of said ultrashort pulsed light beam, said second backward scattered light beam coming from an interface between the anterior aqueous chamber and the crystalline lens of the eyeball, iii) a light absorption characteristics analyzing means for obtaining light absorption characteristics of constituents of the aqueous humor, which fills the anterior aqueous chamber, from the intensity of said first backward scattered light beam and the intensity of said second backward scattered light beam, and iv) a glucose concentration calculating means for calculating a concentration of glucose in the constituents of the aqueous humor from the light absorption characteristics, which have been obtained with respect to the plurality of said ultrashort pulsed light beams having different wavelengths. - View Dependent Claims (6, 7, 8)
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Specification