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Breath test for detection of drug metabolism

  • US 5,962,335 A
  • Filed: 01/03/1997
  • Issued: 10/05/1999
  • Est. Priority Date: 01/03/1997
  • Status: Expired due to Term
First Claim
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1. A method for determining a therapeutic dosage regimen of a drug administered to a subject comprising the steps of:

  • a. labeling a drug sought to be administered therapeutically to a subject with a non-radioactive isotope having a range of natural abundance and being detectable in a metabolite of said drug;

    b. prior to administration of said drug to a subject, measuring a first concentration of said non-radioactive isotope in the subject'"'"'s breath;

    c. following said measuring step, administering said drug labeled with said non-radioactive isotope to the subject;

    d. following the administering step, measuring a second concentration of said non-radioactive isotope in the subject'"'"'s breath, at least one of said first and second concentrations being within the range of natural abundance of the isotope; and

    e. employing the difference between said first and second concentrations to provide information as to a therapeutically acceptable dosage regimen of said drug based on metabolization of said drug by the subject.

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