Breath test for detection of drug metabolism
First Claim
1. A method for determining a therapeutic dosage regimen of a drug administered to a subject comprising the steps of:
- a. labeling a drug sought to be administered therapeutically to a subject with a non-radioactive isotope having a range of natural abundance and being detectable in a metabolite of said drug;
b. prior to administration of said drug to a subject, measuring a first concentration of said non-radioactive isotope in the subject'"'"'s breath;
c. following said measuring step, administering said drug labeled with said non-radioactive isotope to the subject;
d. following the administering step, measuring a second concentration of said non-radioactive isotope in the subject'"'"'s breath, at least one of said first and second concentrations being within the range of natural abundance of the isotope; and
e. employing the difference between said first and second concentrations to provide information as to a therapeutically acceptable dosage regimen of said drug based on metabolization of said drug by the subject.
3 Assignments
0 Petitions
Accused Products
Abstract
A breath test for determining the rate of metabolism of a drug is described. First, a safe and effective amount of the drug, preferably appropriately labelled and most preferably isotopically-labelled, is administered to a subject. After a suitable time period, the exhaled breath of the subject is analyzed to determine the concentration of a metabolite. The concentration of the metabolite is then used to determine the rate of metabolism of the drug. A breath test kit is also described. Such a breath test kit would include an item or items necessary for performing at least one of the methods of determining the rate of metabolism of a drug in a subject. For example, such a breath test kit could include an isotopically-labelled drug to be administered to the subject.
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Citations
4 Claims
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1. A method for determining a therapeutic dosage regimen of a drug administered to a subject comprising the steps of:
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a. labeling a drug sought to be administered therapeutically to a subject with a non-radioactive isotope having a range of natural abundance and being detectable in a metabolite of said drug; b. prior to administration of said drug to a subject, measuring a first concentration of said non-radioactive isotope in the subject'"'"'s breath; c. following said measuring step, administering said drug labeled with said non-radioactive isotope to the subject; d. following the administering step, measuring a second concentration of said non-radioactive isotope in the subject'"'"'s breath, at least one of said first and second concentrations being within the range of natural abundance of the isotope; and e. employing the difference between said first and second concentrations to provide information as to a therapeutically acceptable dosage regimen of said drug based on metabolization of said drug by the subject. - View Dependent Claims (2, 3, 4)
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Specification