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Treatment of bacterial dysentery

  • US 5,962,423 A
  • Filed: 08/07/1998
  • Issued: 10/05/1999
  • Est. Priority Date: 08/07/1998
  • Status: Expired due to Fees
First Claim
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1. A compound of the following structure:

  • 
    
    space="preserve" listing-type="equation">MFC-(LA).sub.n -(BM).sub.nwherein;

    MFC is a multifunctional core molecule,LA is a linker arm,BM is a bridging molecule which includes two or more di-or tri-saccharides, and which can optionally include large oligosaccharides,n is, independently, between 3 and 20,the di- or tri-saccharide moiety are optionally linked to between one and eight additional saccharide moieties, and include an individual saccharide moiety selected from the group consisting of α

    Gal(1→

    4)β

    Gal, α

    Gal(1→

    4)β

    Gal(1→

    4)β

    GlcNAc, and α

    Gal(1→

    4)β

    Gal(1→

    4)β

    Glc,the bridging moieties are bound to at least one linker arm,the linker arms are, independently, C6-20 straight, branched or cyclic alkanes, in which one or more of the carbons may optionally be replaced with an O, S, or amine, and the linker arms can optionally be functionalized at one or more positions with a functional group selected from the group consisting of aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic and substituted heterocyclic,and pharmaceutically acceptable salts thereof.

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