Ocular biometer

• US 5,963,300 A
• Filed: 02/17/1998
• Issued: 10/05/1999
• Est. Priority Date: 02/17/1998
• Status: Expired due to Term

• Current Assignee: Novartis Ag
• Original Assignee: Am Biotechnologies,LLC
• Inventors: Horwitz, Larry S.
• Primary Examiner(s): MANUEL, GEORGE C
• Application Number:
  US09/024,842
• Time in Patent Office: 595 Days
• Field of Search: 351/205, 351/206, 351/207, 351/209, 351/210, 351/211, 351/212, 351/246, 351/247, 356/359, 356/376
• US Class Current: 351/209
• CPC Class Codes: A61B 3/1015 for wavefront analysis
• CPC Class Codes: A61B 3/112 for measuring diameter of pupils

Abstract

An ocular biometer utilizing a light emitting source (7) and corresponding optics to illuminate areas of the eye in order to analyze the wavefront of the reflected light. Aperture sharing elements, such as "hot mirrors" (4) are used to allow the eyes (1) to view the world, as the ocular biometer measures various characteristics of the eye such as the refractive (i.e., accommodative) state, the gaze angle and the pupil diameter at any instant of time and continuously. Optical wavefront conditioning and wavefront sensing techniques are used to determine the refractive power of the eye and the instantaneous accommodative state. Reflected light is projected through a reticle (26) or plurality of reticles (26, 28). Spatial characteristics of the resulting shadow pattern uniquely determine the characteristics of the eye. These shadow patterns can be measured directly or by causing a modulation of the lines with a second identical reticle placed appropriately between the first and the imaging plane. The bright pupil and a Purkinje image may be used to compute the gaze angle (or, line-of-sight). A bright pupil on a dark background wil provide the pupil diameter measurement. The ocular biometer can be configured in a binocular manner so that both eyes can be investigated simultaneously for strabismus, stereopsis and convergence measurements. The depth of modulation of the modulated shadow pattern provides an indication of the acuity of the ocular media and the retinal surface thus providing a means for screening such medical anomalies as diabetic retinopathy, glaucoma and cataracts.

Claims

1. Apparatus for measuring characteristics of the eye compromising:

(a) means for generating an optical wavefront;

(b) means to transmit the optical wavefront to the eye, the wavefront reflecting from various surfaces of the eye;

(c) baffle means for removal of optical wavefront noise;

(d) one or more reticle means through which the reflected optical wavefront is passed to cast a shadow pattern;

(e) means for directing the shadow pattern towards a screen; and

(f) means for analyzing the shadow pattern on the screen to produce measurement data of the characteristics of the wavefront, thereby providing measurement characteristics of the eye.

2. The apparatus of claim 1 wherein the analyzing means compromises computation means for removal of data processing noise.

3. The apparatus of claim 1 further comprising means for generating a collimated beam of a predetermined wavelength to generate the optical wavefront.

4. The apparatus of claim 3 further comprising means to generate a collimated beam with a wavelength of from 780 to 900 nanometers.

5. The apparatus of claim 4 further comprising means to generate a collimated beam with a wavelength of about 840 nanometers and means to direct the beam onto the retinal surface of an eye.

6. The apparatus of claim 1 wherein the means to generate the optical wavefront is a light source with a wavelength of from 780 to 900 nanometers.

7. The apparatus of claim 1 further comprising means for tracking relative movements of the eye in any one or all of three dimensions.

8. Apparatus for measuring the characteristics of the eye comprising:

(a) an illumination source to create an optical wavefront;

(b) one or more aperture sharing elements for transmitting the optical wavefront to the eye, the wavefront reflecting from various surfaces of the eye;

(c) a relay lens arrangement for focusing the wavefront reflected from the eye;

(d) a baffle to eliminate noise;

(e) one or more reticles through which the reflected optical wavefront is passed to cast a shadow pattern;

(f) a screen onto which the shadow pattern is directed;

(g) a camera to image the shadow pattern on the screen;

(h) a computer to analyze the information generated by the shadow pattern.

9. The apparatus of claim 8 further comprising means for generating a collimated beam of a predetermined wavelength to generate the optical wavefront.

10. The apparatus of claim 9 further comprising means to generate a collimated beam with a wavelength of from 780 to 900 nanometers.

11. The apparatus of claim 10 further comprising means to generate a collimated beam with a wavelength of about 840 nanometers and means to direct the beam onto the retinal surface of an eye.

12. The apparatus of claim 8 wherein the means to generate the optical wavefront is a light source with a wavelength of from 780 to 900 nanometers.

13. The apparatus of claim 8 further comprising means for tracking relative movements of the eye in any one or all of three dimensions.

14. A method for measuring characteristics of the eye compromising:

(a) generating an optical wavefront;

(b) transmitting the optical wavefront to the eye, the wavefront reflecting from various surfaces of the eye;

(c) passing the wavefront through a baffle for removal of optical wavefront noise;

(d) passing the reflected optical wavefront through one or more reticles to cast a shadow pattern;

(e) directing the shadow pattern towards a screen; and

(f) analyzing the shadow pattern on the screen to produce measurement data of the characteristics of the wavefront, thereby providing measurement characteristics of the eye.

15. The method of claim 14 comprising removing data processing noise in the analysis.

16. The method of claim 14 comprising generating a collimated beam of a predetermined wavelength to generate the optical wavefront.

17. The method of claim 16 comprising generating a collimated beam with a wavelength of from 780 to 900 nanometers.

18. The method of claim 17 comprising generating a collimated beam with a wavelength of about 840 nanometers and directing the beam onto the retinal surface of an eye.

19. The method of claim 14 comprising generating the optical wavefront using a light source with a wavelength of from 780 to 900 nanometers.

20. The method of claim 14 comprising tracking relative movements of the eye in any one or all of three dimensions.

21. A method for measuring the characteristics of the eye comprising:

(a) creating an optical wavefront;

(b) passing the wavefront through one or more aperture sharing elements;

(c) passing the wavefront through a baffle for removal of optical wavefront noise;

(d) transmitting the optical wavefront to the eye, the wavefront reflecting from various surfaces of the eye;

(e) focusing the wavefront reflected from the eye;

(f) passing the wavefront through one or more reticles to cast a shadow pattern;

(g) directing the shadow pattern onto a screen;

(h) imaging the shadow pattern on the screen with a camera connected to computing means;

(i) analyzing the information imaged on the camera.

22. The method of claim 21 compromises removing data processing noise by the use of analyzing means.

23. The method of claim 21 comprising generating a collimated beam of a predetermined wavelength to generate the optical wavefront.

24. The method of claim 23 comprising generating a collimated beam with a wavelength of from 780 to 900 nanometers.

25. The method of claim 24 comprising generating a collimated beam with a wavelength of about 840 nanometers and directing the beam onto the retinal surface of the eye.

26. The method of claim 21 comprising generating the optical wavefront using a light source with a wavelength of from 780 to 900 nanometers.

27. The method of claim 21 tracking relative movements of the eye in any one or all of three dimensions.

28. A method for measuring a predetermined characteristic of the eye comprising:

(a) generating a collimated light beam;

(b) directing the beam into the eye wherein the beam is reflected from the eye;

(c) directing the reflected beam through a first reticle to develop a shadow pattern;

(d) directing the shadow pattern through a second reticle to develop a moire pattern; and

(e) analyzing the moire pattern to produce measurement data of the eye.

29. The method of claim 28 comprising removal of noise and creating a substantially noise-free moire pattern thereby to provide measurement data of the eye.

30. A method for measuring the refractive characteristics of the eye comprising:

(a) creating an optical wavefront;

(b) passing the wavefront through one or more aperture sharing elements;

(c) directing the optical wavefront to the retinal surface of the eye, the wavefront reflecting from the retinal surface of the eye;

(d) focusing the wavefront reflected from the eye;

(e) passing the wavefront through a baffle for removal of optical wavefront noise;

(f) reforming the wavefront;

(g) passing the wavefront through one or more reticles to cast a shadow pattern;

(f) directing the shadow pattern onto a screen;

(g) imaging the shadow pattern on the screen with a camera connected to computing means;

(h) analyzing the information recorded by the camera.

38. The methods of claims 30, 31, 32, 33, 34, 35, 36 and 37 wherein the measurements are done binocularly, in both eyes simultaneously.

40. The methods of claims 30, 31, 32, 33, 34, 35, 36, 37 and 39 wherein the analysis comprises:

(c) digitizing the shadow patterns;

(d) accumulating the digital images into a single spatial domaine;

(e) converting the spacial domaine to a spatial frequency domaine;

(f) determining the predominant harmonics in the frequency domaine;

(g) correlating the predominant harmonics to the wavefront figure in defined axes;

(h) calculating a three dimensional optical domaine wavefront figure derived from the defined axes;

(i) analyzing the measurements of the wavefront figure.

31. A method for measuring the topographic characteristics of corneal elements of the eye comprising:

(a) creating an optical wavefront;

(b) passing the wavefront through one or more aperture sharing elements;

(c) passing the wavefront through a nulling lens so that the focus is near the center of curvature of the cornea;

(d) directing the optical wavefront to the epithelial surface of the eye, the wavefront reflecting from the epithelial surface of the eye;

(e) passing the wavefront through one or more reticles to cast a shadow pattern;

(f) directing the shadow pattern onto a screen;

(g) imaging the shadow pattern on the screen with a camera connected to computing means;

(h) analyzing the information recorded by the camera.

32. A method for measuring the the topography of the endothelial surface of the eye comprising:

(a) creating an optical wavefront;

(b) passing the wavefront through one or more aperture sharing elements;

(c) directing the optical wavefront globally to the endothelial surface of the eye, the wavefront reflecting from the endothelial surface of the eye;

(d) focusing the wavefront reflected from the eye;

(e) spatial filtering the focused wavefront;

(f) reforming the wavefront;

(g) passing the wavefront through one or more reticles to cast a shadow pattern;

(h) directing the shadow pattern onto a screen;

(i) imaging the shadow pattern on the screen with a camera connected to computing means;

(j) analyzing the information recorded by the camera.

33. A method for measuring the thickness of the cornea of the eye comprising:

(a) creating one or more optical wavefronts;

(b) passing the wavefronts through one or more aperture sharing elements;

(c) directing the optical wavefronts to both the epithelial and endothelial surfaces of the eye, the wavefronts reflecting from both said surfaces;

(d) discriminating the reflected wavefronts by spectral or polarization characteristics;

(e) passing the wavefront through one or more reticles to cast a shadow pattern;

(f) directing the shadow pattern onto a screen;

(g) recording the shadow pattern on the screen with a camera connected to computing means;

(h) analyzing the information recorded by the camera.

34. A method for measuring the pupil of the eye comprising:

(a) creating an optical wavefront;

(b) passing the wavefront through one or more aperture sharing elements;

(c) directing the optical wavefront through the pupil of the eye to the retina, the wavefront reflecting from the retina of the eye;

(d) directing the illumintion onto a screen;

(i) imaging the shadow pattern on the screen with a camera connected to computing means;

(j) analyzing the information recorded by the camera.

35. A method for measuring the optical refractive power of the eye comprising:

(a) creating an optical wavefront;

(b) passing the wavefront through one or more aperture sharing elements;

(c) directing the optical wavefront to the retina of the eye, the wavefront relecting from the retina of the eye;

(d) focusing the wavefront reflected from the retina of the eye;

(e) spatial filtering the focused wavefront;

(f) reforming the wavefront;

(g) passing the wavefront through one or more reticles to cast a shadow pattern;

(h) directing the shadow pattern onto a screen;

(i) imaging the shadow pattern on the screen with a camera connected to computing means;

(j) analyzing the information imaged on the camera to obtain the optical refractive power of the eye.

36. A method for measuring a spatially resolved refraction of the eye comprising:

(a) creating an optical wavefront;

(b) passing the wavefront through one or more aperture sharing elements;

(c) directing the optical wavefront to the retina of the eye, the wavefront reflecting from the retina of the eye;

(d) focusing the wavefront reflected from the eye;

(e) spatial filtering the focused wavefront;

(f) reforming the wavefront;

(g) passing the wavefront through one or more reticles to cast a shadow pattern;

(h) directing the shadow pattern onto a screen;

(i) recording the shadow pattern on the screen with a camera connected to computing means;

(j) analyzing a predetermined specific spatial or angular portion of the eye'"'"'s field of view from the information recorded on the camera.

37. A method for measuring the direction of the line of sight of the eye comprising:

(a) creating an optical wavefront;

(b) passing the wavefront through one or more aperture sharing elements;

(c) directing the optical wavefront to the eye;

(d) imaging the reflected light from the eye at the vertex of the cornea;

(e) measuring the position of the glint of the eye;

(f) measuring the position of the centroid of the pupil of the eye;

(g) analyzing the measurement information.

39. A method for measuring the vergence of the eyes comprising:

(a) creating an optical wavefront;

(b) passing the wavefront through one or more aperture sharing elements;

(c) directing the optical wavefront to both eyes;

(d) imaging the reflected light from the eye at the vertex of the cornea;

(e) measuring the position of the glint of both eyes;

(f) measuring the position of the centroid of the pupil of both eyes;

(g) analyzing the measurement information by comparing the line of sight of both eyes.

41. A method for analyzing an optical wavefront comprising:

(a) generating shadow patterns from the optical wavefront;

(b) collecting the shadow patterns generated;

(c) digitizing the shadow patterns;

(d) accumulating the digital images into a single spatial domaine;

(e) converting the spacial domaine to a spatial frequency domaine;

(f) determining the predominant harmonics in the frequency domaine;

(g) correlating the predominant harmonics to the wavefront figure in defined axes;

(h) calculating a three dimensional optical domaine wavefront figure derived from the defined axes;

(i) analyzing the measurements of the wavefront figure.

42. A method for measuring the refractive characteristics of the eye comprising:

(a) creating an optical wavefront;

(b) passing the wavefront through one or more aperture sharing elements;

(c) directing the optical wavefront to the eye, the wavefront reflecting from the various surfaces of the eye;

(d) focusing the wavefront reflected from the eye;

(e) passing the wavefront through a baffle to eliminate noise;

(e) spatial filtering the wavefront to eliminate ambient noise;

(f) reforming the wavefront;

(g) passing the wavefront through one or more reticles to cast a shadow pattern;

(h) directing the shadow pattern onto a screen;

(i) recording the shadow pattern on the screen with a camera to convert the screen image to spatial digital data;

(j) converting the spatial digital data to spatial frequency data;

(k) determining the dominant spatial frequency;

(l) correlating the dominant spatial frequency to the spherical component along the corresponding axis of the wavefront;

(m) determining the figure of the entire wavefront with the figures of the component axes.