MR-compatible medical devices

• US 5,964,705 A
• Filed: 08/22/1997
• Issued: 10/12/1999
• Est. Priority Date: 08/22/1997
• Status: Expired due to Term

• Current Assignee: Image-Guided Drug Delivery Systems, Inc.
• Original Assignee: Image-Guided Drug Delivery Systems, Inc.
• Inventors: Truwit, Charles L., Liu, Haiying
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): SHAW, SHAWNA JEANNINE
• Application Number:
  US08/916,596
• Time in Patent Office: 781 Days
• Field of Search: 600/423, 600/422, 600/424, 600/11, 600/12, 600/13, 128/899, 128/903, 604/20, 324/318, 324/322
• US Class Current: 600/423
• CPC Class Codes: A61B 5/055 involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• CPC Class Codes: A61B 5/06 Devices, other than using radiation, for detecting or locating foreign bodies for removing same A61B17/50 ; determining position of probes within or on the body of the patient
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61M 25/0108 using radio-opaque or ultrasound markers

Abstract

The use of devices in procedures, especially medical procedures where the events take place under view of Magnetic Resonance Imaging (MRI) systems is becoming more important. Although some general and specific structures have been discussed in the literature and commercialized, little has been done effectively to design devices for MRI procedures for specific tasks. The present invention describes a device for use within an organism, said device comprising an element having at least one pair of opposed RF receiver microcoils having a space between each microcoil of said pair of microcoils, the coils of said microcoils may have diameters of less than 2.4 mm. The device may also comprise an element having at least one pair of opposed RF receiver microcoils having a space between each microcoil of said pair of microcoils, said RF receiver microcoils each comprising at least three individual coils, said at least three individual coils of said microcoils having spacing between adjacent microcoils so that spacing between at least two pairs of individual coils within said microcoils differ by at least 10%. Circuitry may be insulated within the device by providing the wires and circuits within different layers in a coaxial layering of components within the catheter. The device may also comprise device an element having at least one pair of opposed RF receiver microcoils having a space between each microcoil of said pair of microcoils, the RF receiver microcoils each comprising at least three individual windings, the at least three individual windings of said microcoils having spacing between adjacent windings so that spacing between at least two pairs of individual windings within the microcoils differ by at least 10%.

Claims

1. A medical device for use within a living organism, said medical device comprising:

an element having at least one pair of opposed RF receiver microcoils having a space between each microcoil of said pair of microcoils, said RF receiver microcoils each comprising at least three individual windings, said at least three individual windings of said microcoils having spacing between adjacent windings so that spacing between at least two pairs of individual windings within said microcoils differ by at least 10%.

2. The medical device of claim 1 wherein at least one drug delivery port is present within said device and wherein said at least one drug delivery port is located so that at least some drug which is delivered through said port is delivered away from said device within a volume above said space between said individual microcoils of said at least one pair of microcoils.

3. The medical device of claim 2 wherein the windings of said microcoils have diameters of less than 2.4 mm.

4. The medical device of claim 1 wherein there are at least three separate ports within said device for delivery of drugs by at least three microcatheters within said device through said ports.

5. The medical device of claim 4 wherein within said device are at least three deflectors for directing each of said at least three microcatheters through said at least three ports.

6. The medical device of claim 1 wherein at least one set of microcoils comprising a half of said at least one pair of microcoils comprising at least four windings having at least three spaces between adjacent windings of dimensions spacing 1, spacing 2 and spacing three, wherein at least one of said at least three spaces does not equal the dimensions of at least one other of said spaces.

7. The medical device of claim 6 wherein a layer is present within said device which is radially exterior to a component selected from the group consisting of electrical wires and preamplifiers associated with said microcoils, said layer providing RF shielding for said electrical wires and/or any preamplifiers associated with said microcoils, and said layer being electrically insulated from components selected from the group consisting of electrical wires and preamplifiers associated with said microcoils.

8. A medical device for use within a living organism, said medical device comprising:

an element having at least one pair of opposed RF receiver microcoils having a space between each microcoil of said pair of microcoils, said RF receiver microcoils each comprising at least three individual windings, said at least three individual windings of said microcoils having spacing between adjacent windings so that spacing between at least two pairs of individual windings within said microcoils differ by at least 10% wherein said at least one pair of RF receiver microcoils has a space between each half of said pair of microcoils, said at least one pair of RF receiver microcoils produces a field strength having a field strength maximum within a volume surrounding said space between each half of said pair of microcoils, and produces a second field strength at a position along a line parallel to an elongate axis of said device halfway between a midpoint position within said space and a near end of a microcoil forming a part of said at least one pair of RF receiver microcoils, said second field strength, along a line parallel to an elongate axis of said device, being no more than 40% less than said maximum field strength between said microcoils.

9. The medical device of claim 8 wherein said second field strength is no more than 20% less than said maximum field strength.

10. The medical device of claim 9 wherein the windings of said microcoils have diameters of less than 2.4 mm.

11. The medical device of claim 8 wherein the windings of said microcoils have diameters of less than 2.4 mm.

12. The device of claim 8 wherein at least one drug delivery port is present within said device and wherein said at least one drug delivery port is located so that at least some drug which is delivered through said port is delivered away from said device within a volume above said space between said individual microcoils of said at least one pair of microcoils.

13. A medical device for use within an organism, said medical device comprising:

an element having at least one pair of opposed RF receiver microcoils having a space between each microcoil of said pair of microcoils, coils of said microcoils having diameters of less than 2.4 mm wherein at least one set of microcoils comprising a half of said at least one pair of microcoils comprises at least four windings having at least three spaces between adjacent windings of dimensions spacing 1, spacing 2 and spacing three, wherein at least one of said at least three spaces does not equal the dimensions of at least one other of said spaces.

14. The medical device of claim 13 comprising an element having at least one pair of opposed RF receiver microcoils comprising:

at least three windings in each of said microcoils, said windings having a space between each winding of said pair of microcoils, the windings of said microcoils having diameters of less than 2.4 mm and said at least one pair of opposed RF receiver microcoils consisting of a continuous winding.

15. The medical device of claim 14 wherein at least one drug delivery port is present within said device.

16. The medical device of claim 15 wherein said at least one drug delivery port is located so that a drug which is delivered through said port is delivered away from said device within said space between said microcoils.

17. The medical device of claim 14 wherein microcatheters are present within said device which extend outside of said device to deliver liquid material within a volume bordered by planes extending radially from the catheter at ends of the at least one pair of microcoils which volume bordered by planes defines the space between each microcoil within said at least one pair of microcoils.

18. The medical device of claim 14 wherein said at least one pair of microcoils is embedded within a binder material which surrounds a lumen.

19. The medical device of claim 18 wherein said at least one pair of microcoils is electrically connected to a preamplifier within a portion of said device which may be inserted into an organism.

20. The medical device of claim 14 wherein said at least one pair of microcoils is electrically connected to a preamplifier within a portion of said device which may be inserted into an organism.