Implantable system for cell growth control
First Claim
1. An implantable system for growth for insertion into bone or vascular tissue;
- said implantable system comprising porous linked fibrous biomaterial manufactured from nonwoven, randomly-oriented fibers linked together using a fusion source at a plurality of cross-points into a porous structure, said biomaterial having a plurality of voids of a predetermined mean void size effective for stimulating angiogenesis in said biomaterial from the tissue or bone.
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Accused Products
Abstract
An implantable infection shield and system for drug delivery in vascular tissue includes a relatively non-biodegradable porous linked fibrous biomaterial which controls and directs cell growth and angiogenesis from adjacent vascular tissue into the implant. Infection shield embodiments stimulate cell growth and angiogenesis from adjacent vascular tissue which effectively blocks passage of pathogenic microorganisms along percutaneously implanted objects. In embodiments for drug delivery, a reservoir of the same biomaterial may contain either (1) a cell culture system enclosed within a porous sealable interior chamber or (2) a biodegradable matrix in which one or more drugs are dispersed. After implantation of a reservoir of the first embodiment in an organism, cultured cells obtain food and oxygen via diffusion in tissue fluid through the porous walls of the interior chamber, while metabolic products, including drugs, diffuse away from the cell culture in an analogous manner. In a reservoir of the second embodiment, a biodegradable matrix substantially fills the pores (voids), and progressive dissolution of the matrix releases one or more drugs into surrounding tissue fluid. Reservoirs of either embodiment comprise a plurality of voids of a predetermined size effective for stimulating angiogenesis from the surrounding vascular tissue into at least a portion of the reservoir. The reservoir thus acts to couple a source of drugs to the circulatory system of the organism.
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Citations
7 Claims
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1. An implantable system for growth for insertion into bone or vascular tissue;
- said implantable system comprising porous linked fibrous biomaterial manufactured from nonwoven, randomly-oriented fibers linked together using a fusion source at a plurality of cross-points into a porous structure, said biomaterial having a plurality of voids of a predetermined mean void size effective for stimulating angiogenesis in said biomaterial from the tissue or bone.
- View Dependent Claims (2, 3)
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4. A reservoir for coupling a cell culture to vascular tissue in which the reservoir may be implanted, the reservoir comprising
a sealable interior chamber for containing a cell culture, said chamber having a porous wall, said wall comprising linked fibrous biomaterial having a plurality of voids of a predetermined mean void size effective for inhibiting angiogenesis in said wall from the vascular tissue; - and
a porous linked fibrous biomaterial outer coat having a plurality of voids of a predetermined mean void size effective for stimulating angiogenesis in said reservoir from the vascular tissue, said outer coat substantially completely surrounding said sealable interior chamber wall.
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5. A method for making a system for drug delivery for implantation in vascular tissue, the method comprising
obtaining a reservoir comprising porous linked fibrous biomaterial manufactured from nonwoven, randomly-oriented fibers linked together using a fusion source at a plurality of crossing points into a porous structure, said biomaterial having a plurality of voids of a predetermined mean void size effective for stimulating angiogenesis in said reservoir from the vascular tissue; -
providing a biodegradable matrix; dispersing a drug to be delivered in said biodegradable matrix to form a drug delivery matrix; and dispersing said drug delivery matrix within said voids to make a system for drug delivery.
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6. An infection shield for a catheter intended for placement through skin and subcutaneous tissue, the shield comprising
a substantially cylindrically shaped catheter seal for substantially circumferentially surrounding the catheter, the seal comprising porous linked fibrous biomaterial having a plurality of voids of a predetermined mean void size effective for inhibiting angiogenesis from the skin and subcutaneous tissue; - and
a tissue cuff circumferentially surrounding said catheter seal, said cuff comprising porous linked fibrous biomaterial having a plurality of voids of a predetermined mean void size effective for stimulating angiogenesis in said cuff from the skin and subcutaneous tissue. - View Dependent Claims (7)
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Specification