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Close vascularization implant material

  • US 5,964,804 A
  • Filed: 06/07/1995
  • Issued: 10/12/1999
  • Est. Priority Date: 10/31/1990
  • Status: Expired due to Term
First Claim
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1. A device having a wall defining a chamber for holding living cells for implanting into a mammalian host wherein the wall comprises:

  • (a) a first zone of a first porous material proximate the chamber wherein the first porous material is permeable to the flow of nutrients from the host to living cells and products from the living cells to host and impermeable to host immune cells and maintains immunoisolation of the chamber; and

    (b) a second zone of a second porous material outside of the first zone comprising the porous structure as shown in FIG. 4(a) or 4(b), wherein the second porous material comprises frame of elongated strands of material that are less than 5 mm in all but the longest dimension, said frames define apertures which interconnect to form a three dimensional cavities which permit substantially all inflammatory cells migrating into the cavities to maintain a rounded morphology and which promote host vascularization adjacent to but not substantially into the second zone upon implantation into a host.

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