Compounds and compositions for delivering active agents
First Claim
1. A composition comprising(A) at least one biologically active agent;
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3 Assignments
0 Petitions
Accused Products
Abstract
Carrier compounds, compositions, and dosage unit forms therefor which are useful in the delivery of active agents are provided. The present invention provides a compound having the formula: ##STR1## or a salt thereof, wherein the compound may be used in a composition or dosage unit form for delivery of at least one active agent, including a peptide, mucopoly-saccharide, carbohydrate, of a lipid. Methods of administration and preparation of the compounds and compositions of the invention are provided as well, including oral administration. Further, the compositions of the invention may be prepared by mixing at least one active agent, at least one carrier compound, and, optionally, a dosing vehicle.
227 Citations
18 Claims
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1. A composition comprising
(A) at least one biologically active agent; - and
(B) a compound having the following formula ##STR68## or a salt thereof, wherein said biologically active agent is selected from the group consisting of human growth hormone, bovine growth hormone, growth hormone-releasing hormone, an interferon, interleukin-II, insulin, heparin, low molecular weight heparin, calcitonin, erythropoietin, atrial naturetic factor, an antigen, a monoclonal antibody, somatostatin, adrenocorticotropin, gonadotropin releasing hormone, oxytocin, vasopressin, cromolyn sodium, vancomycin, parathyroid hormone, desferrioxamine (DFO), and any combination thereof. - View Dependent Claims (2, 3, 4, 5, 6, 7, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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8. A composition comprising:
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(a) at least one active agent; and (b) a carrier comprising a compound having the following formula;
##STR69## or a salt thereof, wherein said carrier is selected from the group consisting of a poly(amino acid) and a polypeptide.
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18. A method for administering a biologically-active agent to an animal in need of said agent, said method comprising administering orally to said animal a composition comprising
(A) at least one active agent selected from the group consisting of a biologically active agent, a chemically active agent, and a combination thereof; - and
(B) a compound having the following formula ##STR70## or a salt thereof.
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Specification