Hybrid matrix implants and explants
First Claim
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1. A composition comprising a body of matrix material comprising insoluble collagen fibrils, there being embedded within the body of matrix material(a) a plurality of cultured vertebrate cells genetically engineered to express a medically useful polyeptide;
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Abstract
An implantable device having a body of matrix material made up of insoluble collagen fibrils, and disposed therewithin
(a) a plurality of vertebrate cells; and
(b) a plurality of microspheres each of which consists primarily of one or more of the following materials: collagen, polystyrene, dextran, polyacrylamide, cellulose, calcium alginate, latex, polysulfone, or glass.
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Citations
80 Claims
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1. A composition comprising a body of matrix material comprising insoluble collagen fibrils, there being embedded within the body of matrix material
(a) a plurality of cultured vertebrate cells genetically engineered to express a medically useful polyeptide;
- 5. The composition of claim l, wherein the cultured vertebrate cells are transfected cells containing exogenous DNA which includes a regulatory sequence that activates expression of a gene encoding the medically useful polypeptide, said gene being endogenous to said vertebrate cells both prior to and after they are transfected.
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23. A composition comprising a body of matrix material comprising insoluble collagen fibrils, there being embedded within the body of matrix material
(a) a plurality of cultured vertebrate cells genetically engineered to express a medically useful polypeptide; - and
(b) a plurality of microspheres, each of which consists primarily of one or more substances selected from the list consisting of collagen, polystyrene, dextran, polyacrylamide, cellulose, calcium alginate, latex, polysulfone, and glass. - View Dependent Claims (24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 53, 55, 56, 57, 58)
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Specification