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Antisense inhibition of ras gene with chimeric and alternating oligonucleotides

  • US 5,965,722 A
  • Filed: 04/30/1997
  • Issued: 10/12/1999
  • Est. Priority Date: 05/21/1991
  • Status: Expired due to Term
First Claim
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1. An oligonucleotide having at least one portion comprising at least one CH2 --NH--O--CH2, CH2 --N(CH3)--O--CH2, CH2 --O--N(CH3)--CH2, CH2 --N(CH), --N(CH)3 --CH2 or O--N(CH)2 --CH2 CH2 linkage alternating with a phosphorothioate or phosphodiester linkage.

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