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Engineering protein posttranslational modification by PACE/furin in transgenic non-human mammals

  • US 5,965,789 A
  • Filed: 05/04/1995
  • Issued: 10/12/1999
  • Est. Priority Date: 01/11/1991
  • Status: Expired due to Term
First Claim
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1. A non-human transgenic mammal which produces a post-translationally modified first protein, wherein said mammal comprises somatic and germ cells having stably incorporated into the genome of said cells, a first exogenous polynucleotide encoding a first protein susceptible to modification by PACE/furin and a second exogenous polynucleotide encoding PACE/furin, each of said first and second exogenous polynucleotides operatively linked to a mammary epithelial cell specific promoter, and wherein said mammal expresses said first exogenous polynucleotide and said second exogenous polynucleotide in the mammary gland epithelial cells, wherein said PACE/furin post-translationally modifies said first protein, such that said modification results in a post-translationally modified first protein.

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