Non-invasive spine and bone registration for frameless stereotaxy

• US 5,967,982 A
• Filed: 12/09/1997
• Issued: 10/19/1999
• Est. Priority Date: 12/09/1997
• Status: Expired due to Term

• Current Assignee: Cleveland Clinic Foundation
• Original Assignee: Cleveland Clinic Foundation
• Inventors: Barnett, Gene H.
• Primary Examiner(s): Jastrzab, Jeffrey R.
• Assistant Examiner(s): Shaw, Shawna J
• Application Number:
  US08/987,406
• Time in Patent Office: 679 Days
• Field of Search: 600/429, 600/407, 600/414, 600/417, 600/473, 600/476, 600/425-427, 606/130, 378/205, 378/206, 378/37, 378/163, 378/164, 378/166
• US Class Current: 600/429
• CPC Class Codes: A61B 2034/107 Visualisation of planned trajectories or target regions
• CPC Class Codes: A61B 2034/2055 Optical tracking systems
• CPC Class Codes: A61B 2034/2068 using pointers, e.g. pointers having reference marks for determining coordinates of body points
• CPC Class Codes: A61B 2090/363 Use of fiducial points
• CPC Class Codes: A61B 34/10 Computer-aided planning, simulation or modelling of surgical operations
• CPC Class Codes: A61B 34/20 Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
• CPC Class Codes: A61B 90/10 for stereotaxic surgery, e.g. frame-based stereotaxis
• CPC Class Codes: A61B 90/36 Image-producing devices or illumination devices not otherwise provided for

Abstract

An interventionalist or operator uses a variety of apparatus 30 including tools, tool guides, and pointers in a procedure on a region of interest. The region of interest was previously the subject of a diagnostic imaging procedure to generate three dimensional diagnostic image data, selective slices or other portions of which are displayable on video monitors 34. The position of the apparatus 30 in operator space is determined by actuating emitters 32, receiving the emitted signals with receivers 12, and calculating the position of the pointer in operator space. A pair of radio translucent constructions 14, 16 each carry a plurality of radiopaque markers 18 which are positioned adjacent the region of interest. Two or more projection images are taken through the region of interest and the radiopaque markers using a movable x-ray tube 22 and radiation detector 24. The operator uses a control 36 to position cursors on corresponding anatomical markers in both the projection images and images from the diagnostic data to determine a correlation or transform between projection image space and diagnostic data space. The operator positions a tip of the pointer 30 on each of the radiopaque markers and actuates the emitters 32 to determine the position of the radiopaque markers in operator space, i.e. to correlate operator space with projection image space. In this manner, the correlation or transform between operator space and diagnostic data space is generated through the intermediary of projection image space.

Claims

1. A registration apparatus for bringing (i) a tip of a wand, (ii) anatomy of a subject in a patient space, and (iii) three-dimensional diagnostic image data into registration independently of diagnostic imaging hardware, which wand includes at least three emitters for emitting signals indicative of the position of the wand, at least two receivers for receiving the signals, a first image memory for storing a set of the three-dimensional diagnostic image data indicative of the anatomy of the subject, a selecting means for selecting data from the first image memory, and a display for converting the selected data from the first image memory into human-readable displays, further including:

first and second reference plates positioned at a first location and a second location, respectively, the first and second locations being known and on opposing sides relative to a subject, each reference plate including at least three non-collinear radiopaque marks at known locations;

an x-ray source positionable at each of a third location and a fourth location to project x-rays through the first and second locations;

an x-ray detector positioned at each of a fifth location and a sixth location to receive x-rays projected through the first and second locations from the third and fourth locations, respectively, such that x-rays are projected from the x-ray source, through the reference plates and the subject and onto the x-ray detector to generate a first projection images of the three radiopaque marks and the anatomy when the x-ray detector is positioned at the fifth location when the x-ray source is positioned at the third location and a second projection which when the x-ray detector being positioned at the sixth location and the x-ray source is positioned at the fourth location; and

,

a correlator for correlating the set of projection images with the three-dimensional diagnostic image data, a position of a tip of a wand relative to the anatomy in the patient space being correlated with the position of the anatomy in the three-dimensional diagnostic image data in accordance with the correlation between the projection images and the diagnostic image data, whereby the wand tip, the anatomy in patient space, and the diagnostic image are correlated independently of x-ray source and the x-ray detector space.

2. A registration apparatus for a diagnostic imaging system, for determining a position of a tip of a wand relative to an anatomy of a subject in a patient space relative to a position of the wand tip and the anatomy in three-dimensional diagnostic image data, which includes at least three emitters for emitting signals indicative of the position of the wand, at least two receivers for receiving the signals, a first image memory for storing the three-dimensional diagnostic image data indicative of the anatomy of the subject, a selecting means for selecting data from the first image memory, and a display for converting the selected data from the first image memory into human-readable displays, further including:

first and second reference plates positioned at a first location and a second location, respectively, the first and second locations being on opposing sides relative to a patient, each reference plate including at least three non-collinear radiopaque marks at known locations;

an x-ray source and an x-ray detector positioned at each of a plurality of locations to project x-rays from the x-ray source, through the reference plates and the patient and onto the x-ray detector to generate projection images of the three radiopaque marks and the anatomy of the patient; and

,

a correlator for correlating a location of each reference mark in projection image space with the location of the corresponding reference mark in patient space based on offsets, distances, and angles, along with data acquired when the emitters are activated after a tip of a wand is touched to each of the radiopaque marks in the patient space and the radiopaque mark touched by the wand tip is identified in image space, thereby correlating the position of the wand tip relative to the anatomy in the patient space with the position of the anatomy in the three-dimensional diagnostic image data.

3. A method for determining coordinates in an image space, including three-dimensional diagnostic image data of a subject, which correspond to a position of a tip of a wand in a patient space, for use in a system which includes emitters for emitting signals indicative of the position of the wand, receivers for receiving the signals, a subject support, an image memory for storing the diagnostic image data indicative of a three-dimensional region of a portion of the subject which is secured to the subject support means, and a display for converting selected data from the image memory into human-readable displays, the method comprising:

positioning a first reference plate, containing a first set of three non-collinear x-ray opaque reference marks, on a first side of a subject;

positioning a second reference plate, containing a second set of three non-collinear x-ray opaque reference marks, on a second side of the subject such that the subject is disposed between the first and second reference plates;

positioning an x-ray source at a first location relative to the first and second reference plates;

positioning an x-ray detector at a second location relative to the first and second reference plates;

projecting x-rays from the x-ray source, through the reference plates and the subject, to the x-ray detector to generate a first projection image of the anatomy of the subject, the first set of reference marks, and the second set of reference marks;

repositioning the x-ray source and the x-ray detector and projecting x-rays through the subject and the first and second reference points to generate a second projection image; and

,

correlating the first and second projection images with the diagnostic image data for correlating a diagnostic data space and a projection image space.

4. A method for determining coordinates in three-dimensional diagnostic image data of a subject in image space, which coordinates correspond to positions at which a tip of a wand is positioned in a patient space, a subject support, an image memory for storing the diagnostic image data indicative of a three-dimensional region of a portion of the subject which is secured to the subject support means, and a display for converting selected data from the image memory into human-readable displays, the method comprising:

positioning a first reference plate containing a first set of at least three non-collinear x-ray opaque reference marks, on a first side of the subject;

positioning a second reference plate, containing a second set of at least three non-collinear x-ray opaque reference marks, on a second side of the subject such that the subject is disposed between the first and second reference plates;

positioning an x-ray source and an x-ray detector on opposite sides of the first and second reference plates;

projecting x-rays from the x-ray source, through the reference plates and the subject, to the x-ray detector to generate a first projection image of the anatomy of the subject, the first set of reference marks, and the second set of reference marks;

repositioning the x-ray source and the x-ray detector and projecting x-rays through the subject and the first and second reference points to generate a second projection image;

correlating the first and second projection images with the diagnostic image data;

correlating the reference marks with the diagnostic image data; and

,

correlating the positions of a wand with the reference marks such that the position of the wand is correlated with the diagnostic image data.

5. The method as set forth in claim 4 further including:

generating a mathematical transform which transforms between reference marker space coordinates and coordinates in the diagnostic image data; and

,

transforming wand positions using the transform to transform wand positions into diagnostic image coordinates.

6. The method as set forth in claim 5 further including:

generating a human readable display from the diagnostic image data with a cursor at the transformed wand position coordinates superimposed thereon.

7. A method of correlating positions of a tool or tool guide in operator space with coordinates of diagnostic image data in image space, the method comprising:

generating a first projection image through a region of interest of a subject in a first direction;

generating a second projection image through the region of interest in a second projection direction;

identifying corresponding anatomical markers in the first projection image, the second projection image, and the diagnostic image data;

with the corresponding anatomical markers, correlating the first and second projection images with the diagnostic image data to correlate a diagnostic data space and a projection image space;

correlating the projection images with coordinates in operator space to correlate the projection image space with the operator space, within which a tool or a tool guide is positioned adjacent the subject;

during a procedure, determining coordinates of the tool or tool guide in the operator space; and

,

correlating the position of the tool or tool guide in the operator space with a corresponding position in the diagnostic data space as a function of the correlation between the operator space and the projection image space and the correlation between the projection image space and the diagnostic data space.

8. The method as set forth in claim 7 wherein the step of correlating projection image space with operator space includes:

positioning a plurality of radiopaque markers in a fixed relationship to the region of interest such that the radiopaque markers are imaged in the projection images;

correlating positions of the radiopaque markers in projection image space with coordinates of the anatomical markers in projection image space, such that the correlation between the radiopaque markers and the anatomical markers in projection image space and the correlation between the anatomical markers in projection image space and the anatomical markers in diagnostic data space correlate the position of the radiopaque markers in projection image space with diagnostic data space;

determining coordinates of the radiopaque markers in operator space; and

,

from the determined positions of the radiopaque markers in operator space and the coordinates of the anatomical markers in projection image space, correlating operator space and projection image space.

9. The method as set forth in claim 7 wherein the step of correlating projection image space with operator space includes:

positioning a plurality of radiopaque markers in a fixed relationship to the region of interest such that the radiopaque markers are imaged in the projection images;

correlating positions of the radiopaque markers in projection image space with coordinates of the anatomical markers in projection image space, such that the correlation between the radiopaque markers and the anatomical markers in projection image space and the correlation between the anatomical markers in projection image space and the anatomical markers in diagnostic data space correlate the position of the radio markers in projection image space with diagnostic data space;

determining coordinates corresponding to the radiopaque markers in diagnostic data space;

determining coordinates of the radiopaque markers in operator space; and

,

from the determined positions of the radiopaque markers in operator space and the coordinates of the anatomical markers in diagnostic data space, correlating operator space and diagnostic data space.

10. A method of correlating positions of a tool or tool guide in operator space with coordinates of diagnostic image data in image space, the method comprising:

a) generating a first projection image different from the diagnostic image data through a region of interest of a subject in a first direction;

b) generating a second projection image different from the diagnostic image data through the region of interest in a second projection direction;

c) identifying corresponding anatomical markers in the first projection image, the second projection image, and the diagnostic image data;

d) with the corresponding anatomical markers, correlating the projection images with the diagnostic image data to correlate diagnostic data space and projection image space;

e) correlating the projection images with coordinates in operator space to correlate projection image space with operator space, within which a tool or a tool guide is positioned adjacent the subject, the correlating step including;

e1) positioning a Plurality of radiopaque markers in a fixed relationship to the region of interest such that the radiopaque markers are imaged in the projection images;

e2) correlating positions of the radiopaque markers in projection image space with coordinates of the anatomical markers in projection image space, such that the correlation between the radiopaque markers and the anatomical markers in projection image space and the correlation between the anatomical markers in projection image space and the anatomical markers in diagnostic data space correlate the position of the radio markers in projection image space with diagnostic data space;

e3) determining coordinates of the radiopaque markers in operator space, including;

e3a) positioning a tip of a pointer on each of a plurality of the radiopaque markers, each time the tip of the pointer is positioned on one of the radiopaque markers, determining a coordinate of the tip of the pointer in operator space; and

,

e4) from the determined positions of the radiopaque markers in operator space and the coordinates of the anatomical markers in projection image space, correlating operator space and projection image space;

f) during a procedure, determining coordinates of the tool or tool guide in operator space; and

,

g) through the correlation between operator space and projection image space and the correlation between projection image space and diagnostic data space, correlating the position of the tool or tool guide in operator space with a corresponding position in diagnostic data space.

11. The method as set forth in claim 10 wherein the step of determining the coordinate of the pointer tip in operator space includes:

actuating a plurality of emitters disposed on the pointer; and

,

sensing signals emitted by the emitters with at least one receiver mounted in a fixed relation to the subject.

12. The method as set forth in claim 10, wherein the step of correlating positions of the radiopaque markers in projection image space includes:

touching the pointer tip to one of the radiopaque marks in the patient space;

activating the emitters mounted on the pointer;

identifying, in the diagnostic data space, the radiopaque mark touched by the pointer tip; and

,

correlating a location of each radiopaque marker in the diagnostic data space with the location of the corresponding reference mark in the operator space as a function of data acquired when the emitters are activated.

13. An apparatus for correlating positions of a tool or tool guide in an operator space with coordinates of diagnostic image data in an image space, the apparatus comprising:

a computer memory for storing three dimensional diagnostic image data used for generating diagnostic images;

an x-ray source for projecting x-rays through a region of interest of a subject, the x-ray source being movably mounted to project x-rays through the region of interest from a plurality of directions;

an x-ray detector for detecting x-rays projected through the region of interest and converting received x-rays into electronic projection image data;

a computer processor for generating projection images from the electronic projection data signals received from the x-ray detector;

a radio translucent carrier which carries a plurality of radiopaque reference markers, the radio translucent carrier being selectively positioned adjacent the region of interest between the x-ray source and the x-ray detector, such that the radiopaque reference markers are imaged in the projection images;

a tool or tool guide which carries a plurality of emitters, the tool or tool guide being freely positionable around the region of interest, including the radiopaque reference markers;

a receiver for receiving signals emitted by the emitter;

a coordinate processor for correlating an operator space, shown in the projection images including an image of the tool guide, with an image space, shown in diagnostic images, by generating coordinates of the tool or tool guide in the operator space when the tool guide is actuated and identifying corresponding locations in the image space; and

,

at least one monitor for selectively displaying the diagnostic images and the projection images.

14. The apparatus as set forth in claim 13 further including:

a cursor control with which the operator places cursors on corresponding anatomical structures in the projection images and images from the diagnostic data; and

,

a processor for correlating coordinates of the designated anatomical markers in the projection images with coordinates of the designated anatomical markers in the diagnostic image data images to derive a correlation between projection image space and diagnostic data space.

15. The apparatus as set forth in claim 14 further including:

a processor for determining coordinates of the radiopaque markers which appear in the projection images with corresponding coordinates in the diagnostic data space.

16. The apparatus as set forth in claim 14 further including:

a processor for determining coordinates of the radiopaque markers in operator space in response to an operator placing a tip of the tool or tool guide on each of a plurality of radiopaque markers and actuating the emitters; and

,

a processor for processing correlations between the coordinates of the radiopaque reference markers in operator space, correlations between positions of the radiopaque markers in projection image space, positions of anatomical markers in projection image space and diagnostic data space to determine a transform between the operator space and diagnostic image space.