Continuously operating infusion device and method

• US 5,968,014 A
• Filed: 02/24/1998
• Issued: 10/19/1999
• Est. Priority Date: 08/25/1995
• Status: Expired due to Term

• Current Assignee: SMC-Swiss Medical Care S.A.
• Original Assignee: Debiotech S.A.
• Inventors: Bouvier, Bernard, Neftel, Frederic
• Primary Examiner(s): McDermott, Corrine
• Assistant Examiner(s): RODRIGUEZ, CRIS LOIREN
• Application Number:
  US09/029,130
• Time in Patent Office: 602 Days
• Field of Search: 604/131, 604/151, 604/80, 604/191, 604/284, 604/410, 604/122, 604/153, 604/154
• US Class Current: 604/151
• CPC Class Codes: A61M 5/007 for contrast media
• CPC Class Codes: A61M 5/16827 controlling delivery of multiple fluids, e.g. sequencing, mixing or via separate flow-paths infusion of multiple fluids without using a controller A61M5/1407

Abstract

The invention relates to injection apparatus that is capable of operating continuously. According to the invention, the apparatus comprises two independent injection bottles (12) of at least one liquid that is to be injected into a patient via a tube, each of the bottles including means (51) for detecting that injection of the liquid contained in the bottle has terminated, which means control means (53) for interrupting the flow of liquid. The apparatus comprises upstream injection apparatus (10) having two feeder tubes (50) connected to respective bottles (12), and downstream injection apparatus (70) with pump means (72, 84) for pumping the liquid and connected firstly to the patient via a downstream tube (78) and secondly to coupling means (54). An application is performing perfusion prior to radiological examination using an X-ray or an NMR scanner.

Claims

1. Injection apparatus capable of operating continuously, comprising:

two independent injection bottle means containing at least one liquid to be injected into a patient;

a downstream injection assembly comprising a downstream tube and pump means for pumping the liquid, said pump means having a downstream end and an upstream end, said downstream tube connecting said pump means to said patient;

an upstream injection assembly including a first feeder tube, a second feeder tube, and a first and a second link means each comprising a flexible and resilient tube, said first and said second link means being connected to said injection bottle means and connected respectively to said first and second feeder tubes;

a single coupling means having a first inlet and a second inlet and one outlet connected to said upstream end of said pump means, said first and second feeder tubes being respectively connected to said first and second inlets of said single coupling means;

a first and a second interrupter means, operatively coupled to said upstream injection assembly, for interrupting flow of the liquid from the associated injection bottle means to said respective first and second feeder tubes;

a first and a second detection means, operatively coupled to said upstream injection assembly, each comprising an air detector for detecting termination of injection of the liquid contained in said associated injection bottle means; and

control means operatively connected to said first and second detection means and said first and second interrupter means, said control means being arranged to control one of said first and second interrupter means to interrupt flow to one of said feeder tubes when one of said first and second detection means detects that injection of the liquid contained in the associated injection bottle means has terminated and said control means being arranged to control the other of said first and second interrupter means to open flow from the other of said injection bottle means in order to automatically changeover from said one injection bottle means to said other injection bottle means.

2. Injection apparatus according to claim 1,

wherein at least one of said first and second detection means is means for detecting that said injection bottle means is empty.

3. Injection apparatus according to claim 1,

wherein at least one of said first and second detection means is means for monitoring the quantity of liquid that has been passed.

4. Injection apparatus according to claim 1,

wherein the pump means comprise antireturn means preventing the liquid flowing in said downstream injection apparatus from returning into said upstream injection apparatus.

5. Injection apparatus according to claim 4,

wherein the pump means have a tube passing therethrough, and wherein the antireturn means include occlusion means for occluding the tube and included in said pump means, the occlusion means closing said tube when said pump means are not pumping.

6. Injection apparatus according to claim 1,

wherein the coupling means comprise a T-shaped internal duct having two inlet ends secured to respective ones of the first and second feeder tubes and having a third outlet end closed by sealing means for co-operating with the upstream end of the pump means.

7. Injection apparatus according to claim 6,

wherein the coupling means further comprise partial closure means for partially closing the internal duct, enabling liquid to flow either from both inlet ends towards the outlet end or from only one of the two inlet ends towards the outlet end while the other inlet end is closed.

8. Injection apparatus according to claim 6, including a hollow tip situated at the upstream end of the pump means, wherein the sealing means comprise a pre-slit septum for surrounding in elastic manner said hollow tip.

9. Injection apparatus according to claim 1,

wherein at least one of said first and second link means comprises a perforation means for perforating the injection bottle means to enable liquid to flow from the bottle towards the downstream portion of the perforation means and a flexible and resilient tube.

10. Injection apparatus according to claim 9,

wherein the perforation means includes a pin having a beveled hollow tip located upstream from and in communication with an internal duct and a pre-slit latex septum downstream from said internal duct.

11. Injection apparatus according to claim 10,

wherein the pin further comprises air inlet means.

12. Injection apparatus according to claim 10,

wherein the pin further possesses means for supporting and retaining a cap of the bottle enabling the bottle to be held vertically upside-down without further fixing means.

13. Injection apparatus according to claim 10,

wherein the pin further possesses a cylindrical pin body of circular section that is extended upstream from an outer radial shoulder, and wherein the pin body is retained by an annular element for surrounding the pin body and coming into abutment against the outer shoulder.

14. Injection apparatus according to claim 9, including at least one drip chamber, wherein the flexible tube is disposed upstream from said drip chamber and comprises an upstream length and a downstream length, at least one of said first and second detection means for detecting that injection of the liquid contained in the feed source has terminated being located in register with said upstream length.

15. Injection apparatus according to claim 14,

wherein at least one of said first and second interrupter means for interrupting the flow of liquid is located level with said downstream length.

16. Injection apparatus according to claim 9, comprising at least one connection means, interconnected to at least one of said first and second link means and interconnected to said upstream end of said pump means, including a cylindrical wall with one end closed by a septum and surrounded by a cylindrical length downstream from said perforation means and also a rigid cylindrical element having an axial hollow tip upstream from the flexible and resilient tube, and wherein a fixing means includes telescopic sliding engagement between the cylindrical length and the cylindrical rigid element, said engagement causing the hollow tip to penetrate through the septum.

17. Injection apparatus according to claim 1,

wherein at least one of said first and second link means further includes a drip chamber disposed upstream from the feed tube and downstream from at least one of said first and second interrupter means for interrupting the flow of liquid.

18. Injection apparatus according to claim 17,

wherein said drip chamber comprises a bubble trap.

19. Injection apparatus according to claim 17,

wherein the drip chamber includes filter means.

20. Injection apparatus according to claim 17,

wherein the drip chamber includes splash plug means.

21. Injection apparatus according to claim 1,

wherein said pump means further comprise safety means which prevent the pump means from being reused.

22. Injection apparatus according to claim 21,

wherein the safety means comprise an automatically breakable element and a detector system for detecting the absence of the automatically breakable element.

23. Injection apparatus according to claim 22,

wherein at least one of said first and second detection means includes a timer whose starting point occurs upon breaking of the automatically breakable element and which allows injection to be started during its timer period.

24. Injection apparatus according to claim 1,

wherein at least one of said first and second link means is interconnected by connection means that simultaneously perform fixing and establish liquid flow, and wherein said outlet of said coupling means and said upstream end of said pump means are interconnected by said connection means.

25. Injection apparatus according to claim 1, including at least one connection means that comprises a cylindrical wall disposed in the coupling means and having an end closed by a septum and surrounded by a cylindrical length, and wherein the pump means further comprise a cylindrical rigid element having a hollow tip and wherein a fixing means includes telescopic sliding engagement between the cylindrical length and the cylindrical rigid element, said engagement causing the hollow tip to penetrate through the septum.

26. Injection apparatus according to claim 1,

wherein the periphery of the pin body carries coding to enable the pump means to recognize the bottle, including a type and volume of liquid contained in said bottle.

27. Injection apparatus according to claim 1,

wherein the pump means comprise a motor module including rails and at least one groove, and a peristaltic cassette having longitudinal grooves complementary to the rails and at least one resilient tongue whose free end carries a catch for inserting into said groove to ensure that the peristaltic cassette is accurately positioned relative to the motor module.

28. Injection according to claim 27,

wherein the motor module further includes an outlet shaft and detector means for detecting pressure and air, wherein the peristaltic cassette further includes moving parts and a tube, and wherein when the peristaltic cassette is in position in the motor module, the outlet shaft and the detector means are capable of moving simultaneously so that the outlet shaft co-operates with the moving parts and the detector means take up position around the downstream end portion of the tube.

29. Injection according to claim 1,

wherein at least one of said first and second interrupter means comprises pinch means for pinching said flexible and resilient tube to interrupt the flow of the liquid from the associated injection bottle means to the associated feeder tube.

30. An injection method capable of operating continuously, comprising:

providing two independent injection bottle means containing at least one liquid;

providing a downstream injection assembly comprising a downstream tube and pump means for pumping the liquid, said pump means having a downstream end and an upstream end, said downstream tube connecting said pump means to said patient;

providing an upstream injection assembly including a first feeder tube, a second feeder tube, and a first and a second link means each comprising a flexible and resilient tube, said first and said second link means being connected to said injection bottle means and connected respectively to said first and second feeder tubes;

providing a single coupling means having a first inlet and a second inlet and one outlet connected to said upstream end of said pump means, said first and second feeder tubes being respectively connected to said first and second inlets of said single coupling means;

providing a first and a second interrupter means, operatively coupled to said upstream injection assembly, for interrupting flow of the liquid from the associated injection bottle means to said respective first and second feeder tube;

providing a first and a second detection means, operatively coupled to said upstream injection assembly, each comprising an air detector for detecting termination of injection of the liquid contained in said associated injection bottle means;

providing control means operatively connected to said first and second detection means and said first and second interrupter means;

injecting into a patient the liquid from one of said injection bottle means;

detecting termination of injection of the liquid contained in said one injection bottle means;

interrupting, by one of said first and second interrupter means controlled by said control means, flow to said feeder tube being in communication with said one injection bottle means; and

opening flow, by another of said first and second interrupter means controlled by said control means, from the other of said injection bottle means to the associated feeder tube in order to automatically changeover from said one injection bottle means to said other injection bottle means.

31. The injection method according to claim 30 further including another liquid to be injected,

wherein one of the liquids is an active liquid, the other liquid being a purge liquid and the method includes flushing into the patient any active liquid that remains in the downstream injection apparatus when injection of the active liquid has terminated.