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Liquisolid systems and methods of preparing same

  • US 5,968,550 A
  • Filed: 10/01/1997
  • Issued: 10/19/1999
  • Est. Priority Date: 06/10/1996
  • Status: Expired due to Term
First Claim
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1. A free-flowing and readily compressible liquid/powder admixture produced by converting a liquid medication into a liquisolid system, comprising the steps of:

  • (a) selecting a weight (W) of the liquid medication to be included in a single liquisolid system;

    (b) selecting a carrier material and a coating material to be included in the liquisolid system;

    (c) determining the characteristic minimum carrier;

    coating ratio, Rmin, and flowable liquid-retention potentials of the carrier (Φ

    ) and coating (φ

    ) materials using a liquisolid flowability test;

    (d) determining the characteristic compressible liquid-retention potentials of the carrier (Ψ

    ) and coating (ψ

    ) materials using a liquisolid compressibility test;

    (e) selecting a carrier;

    coating ratio, R, where R>

    Rmin, of the carrier and coating materials to be included in the liquisolid system, wherein R=Q/q, Q=the weight of the carrier material, and q=the weight of the coating material;

    (f) calculating the optimum liquid load factor (Lo) of the system according to the equations;

    ##EQU3## (g) calculating the optimum quantities of the carrier (Qo) and coating (qo) materials according to the equations;

    
    
    space="preserve" listing-type="equation">Q.sub.o =W/L.sub.o
    
    
    space="preserve" listing-type="equation">q.sub.o =Q.sub.o /R(h) admixing the liquid medication with the calculated quantity of carrier material (Qo); and

    (i) blending the resulting wet mixture with the calculated amount of coating material (qo) to produce a nonadherent, free-flowing and compressible liquid/powder admixture.

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