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Hormone replacement therapy drug formulations for topical application to the skin

  • US 5,968,919 A
  • Filed: 10/16/1997
  • Issued: 10/19/1999
  • Est. Priority Date: 10/16/1997
  • Status: Expired due to Fees
First Claim
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1. An alcoholic or aqueous alcoholic topical composition for the transdermal delivery of a hormonally active drug which comprises, on a weight basis, of the total composition:

  • from about 0.1 to about 10% of hormonally active drug;

    from about 2 to 20% of skin penetration enhancer comprising C7 to C14 -hydrocarbyl substituted 1,3-dioxolane, 1,3-dioxane or acetal, wherein the hydrocarbyl group substituent has from about 7 to 10 carbon atoms;

    0 to about 25% 1,2-propylene glycol;

    from about 35 to 75% ethanol, isopropanol or mixture thereof;

    0 to about 35% water; and

    ,0 to about 4% of cellulosic thickener.

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