System and method for diagnosis of living tissue diseases

• US 5,970,164 A
• Filed: 02/21/1997
• Issued: 10/19/1999
• Est. Priority Date: 08/11/1994
• Status: Expired due to Term

• Current Assignee: Siemens Computer Aided Diagnosis Ltd. (Siemens AG)
• Original Assignee: Sophisview Technologies Ltd.
• Inventors: Alexandrov, Yuriy, Fields, Scott, Mendelevich, Vlad, Bamberger, Philippe, Leichter, Isaac
• Primary Examiner(s): Johns, Andrew
• Assistant Examiner(s): Davis, Monica S.
• Application Number:
  US08/803,328
• Time in Patent Office: 970 Days
• Field of Search: 364/413.13, 378/37, 382/132, 382/128, 382/274
• US Class Current: 382/128
• CPC Class Codes: G06T 2207/10008 from scanner, fax or copier
• CPC Class Codes: G06T 2207/10116 X-ray image
• CPC Class Codes: G06T 2207/30068 Mammography; Breast
• CPC Class Codes: G06T 2207/30096 Tumor; Lesion
• CPC Class Codes: G06T 5/40 using histogram techniques
• CPC Class Codes: G06T 5/92 based on global image properties
• CPC Class Codes: G06T 7/11 Region-based segmentation

Abstract

A system and method for diagnosis of living tissue diseases is described. The system includes a computer device for controlling its operation. An operator control device is coupled to the computer device. A viewing screen is coupled to the computer device for displaying digitized images of the living tissue. The operator, using the control device, selects desired portions of the digitized image for further image enhancement according to a desired image enhancement feature selectable from a plurality of image enhancement features. The image enhancement features include any combination of grey scale stretching, contrast enhancement based on logarithmic histogram equalization, spot enhancement and magnification. The system further includes means for visualization and quantification of micro-calcifications, and means for visualization and quantification of mass spiculations.

Claims

1. A system for diagnosis of living tissue diseases, comprising:

a computer device for controlling the operation of said system;

an operator control device coupled to said computer device;

a viewing screen coupled to said computer device for displaying digitized images of said living tissue, said operator control device selecting desired portions of said digitized image, and

means for quantification of masses present in said living tissue, said quantification means comprising means for defining the margin of a mass in response to a user-defined seed pixel selected with said operator control device.

2. The system according to claim 1 wherein said mass margin is defined based on a comparison of the grey level of said seed pixel with the grey level of adjacent pixels.

3. The system according to claim 2, wherein a plurality of said mass margins are defined based on a corresponding threshold value used in said seed pixel comparison process, each margin having an associated sharpness value.

4. The system according to claim 3, wherein said plurality of mass margins are presented to the user and one of said plurality of mass margins is selected.

5. The system according to claim 4, wherein at least one parameter associated with a mass defined by said selected mass margin is calculated.

6. A system for diagnosis of living tissue diseases, comprising:

a microcomputer for controlling the operation of said system;

a memory coupled to said microcomputer for storing information as directed by said microcomputer;

a scanning device coupled to said microcomputer for scanning a mammogram to provide a digital image of said mammogram for storing, viewing and further processing;

a viewing screen coupled to said microcomputer wherein said digital image of said mammogram is displayed on said viewing screen;

an operator control device coupled to said microcomputer;

said microcomputer including circuit means enabling on-line display of selected portions of said scanned mammogram; and

means for defining a mass having a corresponding mass margin using a seed pixel selected with said operator control device.

7. The system according to claim 6, further comprising means for defining a plurality of said mass margins each margin having an associated sharpness value.

8. The system according to claim 7, further comprising means for selecting a mass margin from said plurality of mass margins.

9. The system according to claim 8, further comprising means for calculating a parameter associated with said selected mass margin.

10. In a computer based system, a method for diagnosis of living tissue diseases, comprising the steps of:

scanning a mammogram to provide a digital image of said mammogram for storing, viewing and further processing;

displaying said digital image on a viewing screen;

selecting a desired portion of said digital image; and

defining a mass margin in response to a user-defined seed pixel.

11. The method according to claim 10, further comprising the step of defining a plurality of said mass margins each margin having an associated sharpness value.

12. The method according to claim 11, further comprising the step of selecting a mass margin from said plurality of mass margins.

13. The method according to claim 12, further comprising the step of calculating a parameter associated with a mass defined by said selected mass margin.