Apparatus for collection, washing, and reinfusion of shed blood

• US 5,971,948 A
• Filed: 03/14/1997
• Issued: 10/26/1999
• Est. Priority Date: 12/13/1995
• Status: Expired due to Fees

• Current Assignee: Haemonetics Corporation
• Original Assignee: Haemonetics Corporation
• Inventors: Pages, Etienne, Papillon, Jean
• Primary Examiner(s): Weiss, John G.
• Assistant Examiner(s): O, Ki Yong
• Application Number:
  US08/818,314
• Time in Patent Office: 956 Days
• Field of Search: 604/4-6, 210/781, 210/782, 210/645
• US Class Current: 604/6.02
• CPC Class Codes: A61M 1/0209 Multiple bag systems for separating or storing blood components
• CPC Class Codes: A61M 1/3621 Extra-corporeal blood circuits single-needle circuits A61M1/30
• CPC Class Codes: A61M 1/3692 Washing or rinsing blood or blood constituents
• CPC Class Codes: A61M 1/3693 using separation based on different densities of components, e.g. centrifuging
• CPC Class Codes: A61M 1/3696 with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
• CPC Class Codes: A61M 1/604 Bag or liner in a rigid container, with suction applied to both
• CPC Class Codes: A61M 2205/3306 Optical measuring means
• CPC Class Codes: A61M 2205/3344 Measuring or controlling pressure at the body treatment site
• CPC Class Codes: A61M 2205/3351 Controlling upstream pump pressure
• CPC Class Codes: A61M 2205/3393 by weighing the reservoir
• CPC Class Codes: B04B 2005/0478 with filters in the separation chamber

Abstract

An integrated, vacuum-driven shed blood processing system that collects, dilutes, filters and washes postoperatively shed blood and concentrates red blood cells for reinfusion to the patient. The location of the centrifuge bowl between the surgical site and the vacuum source used to clean the site allows the immediate collection of shed blood in the bowl without an intermediate reservoir or an additional pump. In conjunction with a modified centrifuge bowl having a sealed aperture in its floor that permits reinfusion directly from the bowl without an additional reinfusion bag or reverse pump, this configuration processes blood for reinfusion using fewer steps and components yet without loss of functionality. Dilution of the blood upon its introduction into the system reduces the tendency to coagulate and allows the use of lower bowl rotation speeds. Slower rotation reduces red blood cell damage and lowers power requirements, which improves portability.

Claims

1. A method of processing blood from a surgical site on a patient, the method comprising the steps of:

a. providing a source of suction;

b. providing a centrifuge including a centrifuge bowl having an inlet port, a floor, a separation chamber and an outlet port through which fluid exits the chamber;

c. providing a receptacle;

d. fluidly coupling the site and the inlet port;

e. fluidly coupling the outlet port and the receptacle;

f. coupling the suction to the outlet port through the receptacle;

g. compelling the blood from the site into the separation chamber by means of the suction;

h. operating the centrifuge so as to separate the blood into a plurality of components and isolate a fraction of red blood cells in the separation chamber; and

i. conveying at least one of the components, but not the fraction of red blood cells, from the outlet port to a receptacle.

2. The method of claim 1 further comprising the steps of:

a. providing washing solution; and

b. introducing the washing solution into the blood so as to dilute the blood before the blood enters the centrifuge bowl.

3. The method of claim 2 wherein the step of introducing the washing solution into the blood comprises compelling the washing solution into the blood by means of the suction.

4. The method of claim 1 further comprising the steps of:

a. stopping the operation of the centrifuge;

b. forming an aperture in the floor of the chamber so as to allow extraction of red blood cells from the chamber; and

c. reinfusing the isolated fraction of red blood cells into the patient through the aperture.

5. The method of claim 1 further comprising the steps of:

a. stopping the operation of the centrifuge;

b. applying the suction to the inlet port so as to extract a blood component from the chamber.

6. The method of claim 2 wherein the washing solution contains an anticoagulant.

7. The method of claim 1 further comprising the step of filtering the blood before the blood enters the separation chamber.

8. The method of claim 1 wherein the step of operating the centrifuge comprises rotating the centrifuge bowl at a rate lower than 4000 rpm.

9. The method of claim 1 wherein the exiting fluid is compelled to the receptacle by the suction.

10. The method of claim 2 wherein the blood is diluted by the washing solution before the blood enters the centrifuge bowl such that the solution-to-blood volume ratio is at least 1.5 to 1.

11. The method of claim 2 wherein the blood is diluted by the washing solution before the blood enters the centrifuge bowl such that the solution-to-blood volume ratio is at least 1.5 to 1.

12. The method of claim 1 wherein the centrifuge bowl comprises a filter positioned between the inlet port and the separation chamber, the blood passing through the filter before entering the separation chamber.

13. The method of claim 12 wherein the centrifuge bowl comprises an inlet tube extending into the bowl from the inlet port, the inlet tube supporting the filter.

14. The method of claim 1 further comprising the step of controlling operation of the separation chamber on the basis of at least one of:

a. negative pressure the receptacle;

b. weight of the receptacle; and

c. volume of red blood cells in the separation chamber.

15. The method of claim 1 further comprising the step of controlling operation of the source of suction on the basis of at least one of:

a. negative pressure in the receptacle;

b. weight of the receptacle; and

c. volume of red blood cells in the separation chamber.

16. The method of claim 1 wherein a first conduit couples the site and the inlet port and a second conduit couples the out let port and the receptacle.

17. The method of claim 16 further comprising the step of controlling operation of the separation chamber on the basis of at least one of:

a. negative pressure in the first or second conduit; and

b. presence or absence of red blood cells in the second conduit.

18. The method of claim 16 further comprising the step of controlling the operation of the source of suction on the basis of at least one of:

a. negative pressure in the first or second conduit; and

b. presence of absence of red blood cells in the second conduit.

23. The method of claim 1 wherein the step of operating the centrifuge comprises rotating the centrifuge bowl at a rate between 2000 and 3000 rpm.

19. A method of processing blood from a surgical site on a patient, the method comprising the steps of:

a. providing a centrifuge bowl having an inlet port, a separation chamber, a floor, and an outlet port through which fluid exits the bowl;

b. fluidly coupling the site and the inlet port;

c. conveying the blood from the site into the separation chamber;

d. rotating the centrifuge bowl so as to separate the blood into a plurality of components and isolate a fraction of red blood cells in the separation chamber;

e. stopping the rotation of the bowl;

f. forming an aperture in the floor of the bowl so as to allow extraction of red blood cells from the bowl; and

g. reinfusing the fraction of red blood cells into the patient through the aperture.

20. The method of claim 19 further comprising the steps of:

a. providing washing solution; and

b. introducing the washing solution into the blood so as to dilute the blood before the blood enters the centrifuge bowl.

21. The method of claim 19 wherein the centrifuge bowl rotates at a rate lower than 4000 rpm.

22. The method of claim 20 wherein the washing solution contains an anticoagulant.

24. The method of claim 19 wherein the blood is diluted by the washing solution before the blood enters the centrifuge bowl such that the solution-to-blood volume ratio is at least 1.5 to 1.

25. The method of claim 19 wherein the step of rotating the centrifuge bowl comprises rotating the bowl at a rate between 2000 and 3000 rpm.