Blood cell separation devices having a membrane with particular coating

• US 5,972,217 A
• Filed: 11/17/1997
• Issued: 10/26/1999
• Est. Priority Date: 10/17/1994
• Status: Expired due to Fees

• Current Assignee: Baxter International Inc.
• Original Assignee: Baxter International Inc.
• Inventors: Johnson, Richard J., Ung-Chhun, Neng S.
• Primary Examiner(s): KIM, SUN U
• Application Number:
  US08/971,887
• Time in Patent Office: 708 Days
• Field of Search: 210/503, 210/504, 210/505, 210/506, 210/507, 210/508, 210/321.68, 422/101, 427/244, 427/258, 427/384, 427/402, 427/407.1
• US Class Current: 210/321.68
• CPC Class Codes: B01D 39/1692 Other shaped material, e.g. perforated or porous sheets

Abstract

Blood filtration devices and methods of filtering are disclosed. In part, a blood filtration device is provided comprising a housing defining an interior periphery. The device includes a rotating structure mounted within the interior periphery and defining with the housing an annular gap within the interior periphery, an inlet fluid path for allowing a blood product to flow into the annular gap, and the rotating structure including an exterior surface that includes a filter membrane. The filter membrane has a coating thereon comprising an insitu condensation product of a first electrophilically active, high molecular weight polyalkylene oxide and a second high molecular weight bifunctional diamino-polyoxyalkylene oxide derivative.

Claims

1. A blood filtration device comprising:

a housing defining an interior periphery;

a rotating structure mounted within the interior periphery and defining with the housing an annular gap within the interior periphery;

an inlet fluid path for allowing a blood product to flow into the annular gap;

the rotating structure including an exterior surface that includes a filter membrane; and

the filter membrane having a coating thereon comprising an insitu condensation product of a first electrophilically active, high molecular weight polyalkylene oxide and a second high molecular weight bifunctional diamino-polyoxyalkylene derivative, wherein the polyalkylene oxides can comprise up to polybutylene oxide.

2. The blood filtration device of claim 1 wherein said first electrophilically active, high molecular weight polyalkylene oxide compound has the general structure Y-PEO-R-PEO-Y wherein Y is a reactive moiety selected from the group consisting of oxycarbonylimidazole;

tresyl-, tosyl-, N-hydroxysuccinimidyl-, and p-nitrophenyl-activated esters;

acrylates;

glycidyl ethers; and

aldehydes, wherein R is a spacer selected from compounds containing carbon, nitrogen, oxygen, and/or sulfur atoms, and wherein PEO is a high molecular weight polyalkylene oxide.

3. The blood filtration device of claim 1 wherein said spacer R is bisphenol A or bisphenol B.

4. A blood filtration device comprising:

a housing;

a permeable filter structure having a membrane filter and a coating thereon comprising an isopolymer of a high molecular weight tetraacrylatepolyalkylene oxide polymerized by exposure to radiation, the permeable filter being located in the housing and being rotatable about an axis;

an annular gap between the housing and the permeable filter structure;

a liquid inlet port connectable to a blood supply and providing fluid communication to the annular gap; and

a drive member to rotate the filter structure at a speed sufficient to create a shear rate.

5. A system for separating filtrate from a fluid suspension, the system comprising:

a housing body having a hollow interior and an inner surface;

a rotor member rotatable within the interior of the housing body, the rotor member having an outer surface spaced from the inner housing surface to define a gap therebetween;

an inlet fluid path for allowing a blood product to flow into the gap;

a microporous filter membrane attached tot he outer surface of the rotor member for common rotation therewith, the filter having a coating thereon comprising an irradiated condensation product of a high molecular weight tetraacrylatepolyalkylene oxide; and

a device for rotating the rotor member.

6. A blood filtration device comprising:

a housing body having a hollow interior and an inner surface;

a rotor member rotatable within the interior of the housing body, the rotor member having an outer surface spaced from the inner housing surface to define a gap therebetween;

an inlet for supplying a blood product into the gap;

a microporous filter membrane defining the outer surface of the rotor member, the filter matrix having a coating thereon comprising an insitu condensation product of a first electrophilically active, high molecular weight polyalkylene oxide and a second high molecular weight bifunctional diamino-polyoxyalkylene derivative, wherein the polyalkylene oxides can comprise up to polybutylene oxide; and

a device for rotating the rotor member.