Blood cell separation devices having a membrane with particular coating
First Claim
1. A blood filtration device comprising:
- a housing defining an interior periphery;
a rotating structure mounted within the interior periphery and defining with the housing an annular gap within the interior periphery;
an inlet fluid path for allowing a blood product to flow into the annular gap;
the rotating structure including an exterior surface that includes a filter membrane; and
the filter membrane having a coating thereon comprising an insitu condensation product of a first electrophilically active, high molecular weight polyalkylene oxide and a second high molecular weight bifunctional diamino-polyoxyalkylene derivative, wherein the polyalkylene oxides can comprise up to polybutylene oxide.
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Accused Products
Abstract
Blood filtration devices and methods of filtering are disclosed. In part, a blood filtration device is provided comprising a housing defining an interior periphery. The device includes a rotating structure mounted within the interior periphery and defining with the housing an annular gap within the interior periphery, an inlet fluid path for allowing a blood product to flow into the annular gap, and the rotating structure including an exterior surface that includes a filter membrane. The filter membrane has a coating thereon comprising an insitu condensation product of a first electrophilically active, high molecular weight polyalkylene oxide and a second high molecular weight bifunctional diamino-polyoxyalkylene oxide derivative.
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Citations
6 Claims
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1. A blood filtration device comprising:
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a housing defining an interior periphery; a rotating structure mounted within the interior periphery and defining with the housing an annular gap within the interior periphery; an inlet fluid path for allowing a blood product to flow into the annular gap; the rotating structure including an exterior surface that includes a filter membrane; and the filter membrane having a coating thereon comprising an insitu condensation product of a first electrophilically active, high molecular weight polyalkylene oxide and a second high molecular weight bifunctional diamino-polyoxyalkylene derivative, wherein the polyalkylene oxides can comprise up to polybutylene oxide. - View Dependent Claims (2, 3)
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4. A blood filtration device comprising:
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a housing; a permeable filter structure having a membrane filter and a coating thereon comprising an isopolymer of a high molecular weight tetraacrylatepolyalkylene oxide polymerized by exposure to radiation, the permeable filter being located in the housing and being rotatable about an axis; an annular gap between the housing and the permeable filter structure; a liquid inlet port connectable to a blood supply and providing fluid communication to the annular gap; and a drive member to rotate the filter structure at a speed sufficient to create a shear rate.
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5. A system for separating filtrate from a fluid suspension, the system comprising:
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a housing body having a hollow interior and an inner surface; a rotor member rotatable within the interior of the housing body, the rotor member having an outer surface spaced from the inner housing surface to define a gap therebetween; an inlet fluid path for allowing a blood product to flow into the gap; a microporous filter membrane attached tot he outer surface of the rotor member for common rotation therewith, the filter having a coating thereon comprising an irradiated condensation product of a high molecular weight tetraacrylatepolyalkylene oxide; and a device for rotating the rotor member.
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6. A blood filtration device comprising:
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a housing body having a hollow interior and an inner surface; a rotor member rotatable within the interior of the housing body, the rotor member having an outer surface spaced from the inner housing surface to define a gap therebetween; an inlet for supplying a blood product into the gap; a microporous filter membrane defining the outer surface of the rotor member, the filter matrix having a coating thereon comprising an insitu condensation product of a first electrophilically active, high molecular weight polyalkylene oxide and a second high molecular weight bifunctional diamino-polyoxyalkylene derivative, wherein the polyalkylene oxides can comprise up to polybutylene oxide; and a device for rotating the rotor member.
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Specification