Alendronate therapy to prevent loosening of, or pain associated with, orthopedic implant devices
First Claim
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1. A method of preventing loosening of an orthopedic prosthesis in a subject comprising administering to the subject a bone resorption inhibiting amount of a bisphosphonate or a pharmaceutically acceptable salt thereof.
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Abstract
Disclosed is a therapy for treating and for preventing periprosthetic bone loss by the administration of a bisphosphonate bone resorption inhibitor, e.g., alendronate, in patients who have an orthopedic implant device.
16 Citations
6 Claims
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1. A method of preventing loosening of an orthopedic prosthesis in a subject comprising administering to the subject a bone resorption inhibiting amount of a bisphosphonate or a pharmaceutically acceptable salt thereof.
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2. A method of prevent loosening of a hip prosthesis in a subject comprising administering a bone resorption inhibiting amount of a bisphosphonate or a pharmaceutically acceptable salt thereof.
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3. A method of preventing or alleviating pain associated with loosening of an orthopedic prosthesis in a subject comprising administering to the subject a bone resorption inhibiting amount of a bisphosphonate or a pharmaceutically acceptable salt thereof.
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4. A method of preventing or alleviating pain associated with the loosening of a hip prosthesis in a subject comprising administering to the subject a bone resorption inhibiting amount of a bisphosphonate or a pharmaceutically acceptable salt thereof.
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5. A method of retarding loosening of an orthopedic prosthesis in a sunject comprising administering to the subject a bone resorption inhibiting amount of a bisphosphonate or a pharmaceutically acceptable sallt thereof.
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6. A method of retarding lessening of a hip prosthesis in a subject comprising administering to the patient a bone resorption inhibiting amount of a bisphosphonate or a pharmaceutically acceptable salt thereof.
Specification