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Computer-aided visualization and analysis system for sequence evaluation

  • US 5,974,164 A
  • Filed: 10/16/1995
  • Issued: 10/26/1999
  • Est. Priority Date: 10/21/1994
  • Status: Expired due to Term
First Claim
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1. In a computer system, a method of identifying mutations in a sample nucleic acid sequence, said method comprising the steps of:

  • inputting a first set of probe intensities, each of said probe intensities in said first set being associated with a nucleic acid probe and indicating hybridization affinity between said associated nucleic acid probe and a reference nucleic acid sequence;

    inputting a second set of probe intensities, each of said probe intensities in said second set being associated with a nucleic acid probe and indicating hybridization affinity between said associated nucleic acid probe and said sample sequences;

    said computer system comparing probe intensities in said first set and probe intensities in said second set to select hybridization regions where said probe intensities in said first set and said probe intensities in said second set differ, each region including multiple base positions; and

    identifying mutations in said sample sequence according to characteristics of said selected regions.

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